Prof. Sebastian Karpf of the Institute of Biomedical Optics (BMO) has been awarded €518,864 by the German Research Foundation (DFG) for the international project ADAPT: Adaptive and predictive arbitrary point scanning two photon tomography. The project, submitted in the framework of the collaborative, pan-European WEAVE program will explore SLIDE microscopy, invented by Prof. Karpf, for adaptive neural imaging. ADAPT is a collaboration between the University of Lübeck (Prof. Karpf), KU Leuven in Belgium (Prof. Pieter Vanden Berghe) and the University of Geneva (Dr. Luigi Bonacina).
The reviewers praised that „The SLIDE system would be an invaluable advance for in vivo functional imaging. Currently, the speed of image acquisition with 2-photon microscopes limits imaging to a single optical section in order to achieve the necessary frame rate. SLIDE would enable volumetric imaging at frame rates comparable to or exceeding those currently possible for single optical sections.”.
The project will run for 3 years, where at BMO a new SLIDE light source at 940nm will be developed (AG Karpf), adaptive SLIDE imaging parameters enabling increased imaging speed and sensitivity (Dr. Bonacina, UniGE), and SLIDE applied to fast volumetric imaging of neuronal activity (Prof. Vanden Berghe, KU Leuven) to contribute to further biological understanding of neuronal communications in gut and brain.
Prof. Sebastian Karpf coordinates new European project ADAPT
