2023
Awanish P.
Singh,
Madita
Göb,
Martin
Ahrens,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Robert
Huber, and
Maik
Rahlves,
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Mar.2023. pp. 1236703.
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Mar.2023. pp. 1236703.
DOI: | 10.1117/12.2652955 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652955, author = {Awanish Pratap Singh and Madita G{\"o}b and Martin Ahrens and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H{\"u}ttmann and Robert Huber and Maik Rahlves}, title = {{Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236703}, abstract = {High-speed endoscopic optical coherence tomography (OCT) imaging in the MHz range has shown great potential in various medical applications ranging from cancer screening to vascular disease monitoring. High-speed imaging always suffers from non-uniform rotational distortion (NURD) due to asynchronous motor rotation with the OCT system. Several research groups have previously attempted to solve this problem, using either an expensive motor with a sensor or numerical correction after data acquisition. However, both techniques pose challenges for practical use. Therefore, in this study, we use an inexpensive sensorless brushless DC motor with a Fourier domain mode-locked (FDML) laser-based MHz OCT system and try to resolve the problem of synchronization using three different modalities, (i) Slave-mode: The FDML frequency serves as a master frequency for the motor, which is phase-locked to the FDML frequency, (ii) Master-mode: The revolution trigger obtained from the motor’s back electromotive force (BEMF) signal serves as a trigger signal for the OCT imaging system, (iii) Both: Fully synchronized setup, where the motor rotation is synchronized with the laser and the imaging system is synchronized with the motor to achieve phase-stable OCT imaging. The first case slightly fluctuates in live preview and imaging due to the absence of a revolution trigger, while the second has varying motor speeds. Therefore, we use the third case to phase-lock the motor with FDML and get a distortion-free live preview and image acquisition. Finally, we demonstrate high-speed SS-OCT structural imaging (at 3.3 MHz A-scan rates) of a finger with a 16 mm diameter probe (at 40,000 rpm).}, keywords = {Optical Coherence Tomography, Endoscopy, FDML , Closed Loop Motor Control, NURD compensation, Brushless DC Motor, Back Electromotive Force}, year = {2023}, doi = {10.1117/12.2652955}, URL = {https://doi.org/10.1117/12.2652955} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christian
Hagel,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, Mar.2023. pp. 1236805.
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, Mar.2023. pp. 1236805.
DOI: | 10.1117/12.2649963 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649963, author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann}, title = {{Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography}}, volume = {12368}, booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI}, editor = {Caroline Boudoux and James W. Tunnell}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236805}, abstract = {The ill-defined tumor borders of glioblastoma multiforme pose a major challenge for the surgeon during tumor resection, since the goal of the tumor resection is the complete removal, while saving as much healthy brain tissue as possible. In recent years, optical coherence tomography (OCT) was successfully used to classify white matter from tumor infiltrated white matter by several research groups. Motivated by these results, a dataset was created, which consisted of sets of corresponding ex vivo OCT images, which were acquired by two OCT-systems with different properties (e.g. wavelength and resolution). Each image was annotated with semantic labels. The labels differentiate between white and gray matter and three different stages of tumor infiltration. The data from both systems not only allowed a comparison of the ability of a system to identify the different tissue types present during the tumor resection, but also enable a multimodal tissue analysis evaluating corresponding OCT images of the two systems simultaneously. A convolutional neural network with dirichlet prior was trained, which allowed to capture the uncertainty of a prediction. The approach increased the sensitivity of identifying tumor infiltration from 58 % to 78 % for data with a low prediction uncertainty compared to a previous monomodal approach. }, keywords = {optical coherence tomography, oct, brain, classification, tumor, dual wavelength, glioblastoma multiforme, tissue analysis}, year = {2023}, doi = {10.1117/12.2649963}, URL = {https://doi.org/10.1117/12.2649963} } |
Nicolas
Detrez,
Sazgar
Burhan,
Paul
Strenge,
Jessica
Kren,
Christian
Hagel,
Matteo Mario
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis, in Emerging Technologies for Cell and Tissue Characterization II , Seemantini K. Nadkarni and Giuliano Scarcelli, Eds. SPIE, 2023. pp. 126290M.
Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis, in Emerging Technologies for Cell and Tissue Characterization II , Seemantini K. Nadkarni and Giuliano Scarcelli, Eds. SPIE, 2023. pp. 126290M.
DOI: | 10.1117/12.2670944 |
File: | 12.2670944 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670944, author = {Nicolas Detrez and Sazgar Burhan and Paul Strenge and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis}}, volume = {12629}, booktitle = {Emerging Technologies for Cell and Tissue Characterization II}, editor = {Seemantini K. Nadkarni and Giuliano Scarcelli}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126290M}, keywords = {Optical Coherence Elastography, Air-Jet, Phase-sensitive OCT, Histology Structure Analysis, Color-Deconvolution, Structural Tensors, Brain tumor, Tissue Characterization}, year = {2023}, doi = {10.1117/12.2670944}, URL = {https://doi.org/10.1117/12.2670944} } |
Nicolas
Detrez,
Sazgar
Burhan,
Katharina
Rewerts,
Jessica
Kren,
Christian
Hagel,
Matteo Mario
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data, in Optical Elastography and Tissue Biomechanics X , Kirill V. Larin and Giuliano Scarcelli and Frédérique Vanholsbeeck, Eds. SPIE, 2023. pp. 1238105.
Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data, in Optical Elastography and Tissue Biomechanics X , Kirill V. Larin and Giuliano Scarcelli and Frédérique Vanholsbeeck, Eds. SPIE, 2023. pp. 1238105.
DOI: | 10.1117/12.2649835 |
File: | 12.2649835 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649835, author = {Nicolas Detrez and Sazgar Burhan and Katharina Rewerts and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data}}, volume = {12381}, booktitle = {Optical Elastography and Tissue Biomechanics X}, editor = {Kirill V. Larin and Giuliano Scarcelli and Fr{\'e}d{\'e}rique Vanholsbeeck}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1238105}, keywords = {Optical Coherence Elastography, Air-Jet, Air-Puff, biomechanics, viscoelasticity, rheology, brain tissue, brain tumor}, year = {2023}, doi = {10.1117/12.2649835}, URL = {https://doi.org/10.1117/12.2649835} } |
Lara
Buhl,
Maron
Dolling,
Stefan
Kassumeh,
Siegfried G.
Priglinger,
Rox R.
Anderson,
Mark
Bischoff, and
Reginald
Birngruber,
Corneal filler injection for enhancement after myopic small-incision lenticule extraction (SMILE), 2023.
Corneal filler injection for enhancement after myopic small-incision lenticule extraction (SMILE), 2023.
DOI: | 10.1117/12.2649215 |
Alexander
Altmann,
Mohammad
Khodaygani,
Martin
Leucker,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Fluorescence based detection of gaseous food spoilage indicators, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270I.
Fluorescence based detection of gaseous food spoilage indicators, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270I.
DOI: | 10.1117/12.2671751 |
File: | 12.2671751 |
Bibtex: | ![]() @inproceedings{10.1117/12.2671751, author = {Alexander Altmann and Mohammad Khodaygani and Martin Leucker and Christian Schell and Ramtin Rahmanzadeh}, title = {{Fluorescence based detection of gaseous food spoilage indicators}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126270I}, keywords = {fluorescence spectroscopy, gas sensing, optode technology, food safety, porphyrins, SVM classifier}, year = {2023}, doi = {10.1117/12.2671751}, URL = {https://doi.org/10.1117/12.2671751} } |
Paula
Enzian,
Birgit
Lange,
Zuzana
Penxova,
Anke
Leichtle,
Yoko
Miura,
Karl-Ludwig
Bruchhage, and
Ralf
Brinkmann,
Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126271T.
Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126271T.
DOI: | 10.1117/12.2670902 |
File: | 12.2670902 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670902, author = {Paula Enzian and Birgit Lange and Zuzana Penxov{\'a} and Anke Leichtle and Yoko Miura and Karl-Ludwig Bruchhage and Ralf Brinkmann}, title = {{Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126271T}, keywords = {FLIM, autofluorescence, otitis media, cholesteatoma, middle ear, inflammation}, year = {2023}, doi = {10.1117/12.2670902}, URL = {https://doi.org/10.1117/12.2670902} } |
A. Martínez
Jiménez,
M.
Spacek,
Melanie
Wacker,
Robert
Huber,
A.
Bradu, and
Adrian
Podoleanu,
MHz time stretch swept source using a commercial erbium-doped fiber amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 1236706.
MHz time stretch swept source using a commercial erbium-doped fiber amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 1236706.
DOI: | 10.1117/12.2651127 |
File: | 12.2651127 |
Bibtex: | ![]() @inproceedings{10.1117/12.2651127, author = {A. Mart{\'i}nez Jim{\'e}nez and M. Spacek and M. Wacker and R. Huber and A. Bradu and A. Podoleanu}, title = {{MHz time stretch swept source using a commercial erbium-doped fiber amplifier}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236706}, keywords = {swept source, time-stretch, optical coherence tomography, mode-locking}, year = {2023}, doi = {10.1117/12.2651127}, URL = {https://doi.org/10.1117/12.2651127} } |
Wolfgang
Draxinger,
Dirk
Theisen-Kunde,
Lion
Schuetz,
Nicolas
Detrez,
Paul
Strenge,
Maximilian
Rixius,
Veit
Danicke,
Wolfgang
Wieser,
Jessica
Kren,
Patrick
Kuppler,
Sonja
Spar-Hess,
Matteo Mario Bonsanto
M.D.,
Ralf
Brinkmann, and
Robert
Huber,
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270W.
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270W.
DOI: | 10.1117/12.2670953 |
File: | 12.2670953 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670953, author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber}, title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126270W}, keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics}, year = {2023}, doi = {10.1117/12.2670953}, URL = {https://doi.org/10.1117/12.2670953} } |
Christin
Grill,
Julie-Jacqueline
Kuhl,
Maximiliane Amelie
Schlenz, and
Ralf
Brinkmann,
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
DOI: | 10.1117/12.2670874 |
File: | 12.2670874 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670874, author = {Christin Grill and Julie-Jacqueline Kuhl and Maximiliane Amelie Schlenz and Ralf Brinkmann}, title = {{Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126320J}, keywords = {Optical Coherence Tomography, OCT, Monolithic dental crowns, CAD/CAM materials, Microcracks, Non-destructive method, Fatigue damage, Dental materials}, year = {2023}, doi = {10.1117/12.2670874}, URL = {https://doi.org/10.1117/12.2670874} } |
Sazgar
Burhan,
Nicolas
Detrez,
Katharina
Rewerts,
Madita
Göb,
Steffen
Buschschlüter,
Christian
Hagel,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Phase analysis strategies for MHz OCE in the large displacement regime, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 123670Q.
Phase analysis strategies for MHz OCE in the large displacement regime, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 123670Q.
DOI: | 10.1117/12.2652847 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652847, author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Steffen Buschschl{\"u}ter and Christian Hagel and Matteo Mario Bonsanto M.D. and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Phase analysis strategies for MHz OCE in the large displacement regime}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {123670Q}, abstract = {In neurosurgical tumor operations on the central nervous system, intraoperative haptic information often assists for discrimination between healthy and diseased tissue. Thus, it can provide the neurosurgeon with additional intraoperative source of information during resection, next to the visual information by the light microscope, fluorescent dyes and neuronavigation. One approach to obtain elastic and viscoelastic tissue characteristics non-subjectively is phase-sensitive optical coherence elastography (OCE), which is based on the principle of optical coherence tomography (OCT). While phase-sensitive OCE offers significantly higher displacement sensitivity inside a sample than commonly used intensity-based correlation methods, it requires a reliable algorithm to recover the phase signal, which is mathematically restricted in the -π to π range. This problem of phase wrapping is especially critical for inter-frame phase analysis since the time intervals between two referenced voxels is long. Here, we demonstrate a one-dimensional unwrapping algorithm capable of removing up to 4π-ambiguities between two frames in the complex phase data obtained from a 3.2 MHz-OCT system. The high sampling rate allows us to resolve large sample displacements induced by a 200 ms air pulse and acquires pixel-precise detail information. The deformation behavior of the tissue can be monitored over the entire acquisition time, offering various subsequent mechanical analysis procedures. The reliability of the algorithm and imaging concept was initially evaluated using different brain tumor mimicking phantoms. Additionally, results from human ex vivo brain tumor samples are presented and correlated with histological findings supporting the robustness of the algorithm.}, keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, Phase-sensitive OCT, Phase Unwrapping, Brain tumor, Biomechanics}, year = {2023}, doi = {10.1117/12.2652847}, URL = {https://doi.org/10.1117/12.2652847} } |
Dirk
Theisen-Kunde,
Claus
Burchard,
Veit
Danicke,
Jan-Eric
Fleger,
Christopher
Kren,
Sebastian
Wittmeier,
Johann
Roider, and
Ralf
Brinkmann,
Real-time temperature-control for cw retinal laser therapy in a clinical study, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 1262723.
Real-time temperature-control for cw retinal laser therapy in a clinical study, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 1262723.
DOI: | 10.1117/12.2670839 |
File: | 12.2670839 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670839, author = {Dirk Theisen-Kunde and Claus von der Burchard and Veit Danicke and Jan-Eric Fleger and Christopher Kren and Sebastian Wittmeier and Johann Roider and Ralf Brinkmann}, title = {{Real-time temperature-control for cw retinal laser therapy in a clinical study}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1262723}, keywords = {retinal laser, real time temperature control, clinical study, CSCR}, year = {2023}, doi = {10.1117/12.2670839}, URL = {https://doi.org/10.1117/12.2670839} } |
Dirk
Theisen-Kunde,
Florian
Sommer,
Veit
Danicke,
Lion
Schützeck,
Stefan
Meyer,
Christopher
Kren,
Maximilian
Rixius, and
Sebastian
Karpf,
Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy, in Advances in Microscopic Imaging IV , Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park, Eds. SPIE, 2023. pp. 126300Q.
Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy, in Advances in Microscopic Imaging IV , Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park, Eds. SPIE, 2023. pp. 126300Q.
DOI: | 10.1117/12.2670881 |
File: | 12.2670881 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670881, author = {Dirk Theisen-Kunde and Florian Sommer and Veit Danicke and Lion Sch{\"u}tzeck and Stefan Meyer and Christopher Kren and Maximilian Rixius and Sebastian Karpf}, title = {{Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy}}, volume = {12630}, booktitle = {Advances in Microscopic Imaging IV}, editor = {Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126300Q}, keywords = {multiphoton microscopy, flow cytometry, Fourier Domain Mode Locked Laser, SLIDE, kHz- Imaging}, year = {2023}, doi = {10.1117/12.2670881}, URL = {https://doi.org/10.1117/12.2670881} } |
2022
Madita
Göb,
Sazgar
Burhan,
Simon
Lotz, and
Robert
Huber,
Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Mar.2022. pp. 27 -- 31.
Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Mar.2022. pp. 27 -- 31.
DOI: | 10.1117/12.2612171 |
Bibtex: | ![]() @inproceedings{10.1117/12.2612171, author = {Madita G{\"o}b and Sazgar Burhan and Simon Lotz and Robert Huber}, title = {{Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT}}, volume = {11948}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1194807}, abstract = {We demonstrate ultra-large field of view OCT scanning using standard optics, a X-Y-galvanometer scanner and a synchronously driven motorized XYZ-positioning stage. The integration of a movable stage into our self-built 3.3 MHz- OCT system allows acquiring coherent ultra-large area images, fully leveraging the high speed potential of our system. For fast OCT-angiography, one galvanometer axis scanner is driven in a repetitive sawtooth pattern, fully synchronized to the movement of the linear stage, to obtain multiple measurements at each position. This technique requires exact synchronization, precise repositioning, and uniform movements with low tolerances to ensure a minimum revisitation error. We analyze error and performance of our setup and demonstrate angiographic imaging.}, keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, FDML, Optical Coherence Angiography, OCTA, Medical optics and biotechnology, Medical imaging, Three-dimensional image acquisition, Scanners, Microscopy}, year = {2022}, doi = {10.1117/12.2612171}, URL = {https://doi.org/10.1117/12.2612171} } |
Marie
Klufts,
Simon
Lotz,
Muhammad Asim
Bashir,
Sebastian
Karpf, and
Robert
Huber,
Ultra-high-accuracy chromatic dispersion measurement in optical fibers, in Optical Components and Materials XIX , Shibin Jiang and Michel J. F. Digonnet, Eds. SPIE, Mar.2022. pp. 119970L.
Ultra-high-accuracy chromatic dispersion measurement in optical fibers, in Optical Components and Materials XIX , Shibin Jiang and Michel J. F. Digonnet, Eds. SPIE, Mar.2022. pp. 119970L.
DOI: | 10.1117/12.2608773 |
Bibtex: | ![]() @inproceedings{10.1117/12.2608773, author = {M. Klufts and S. Lotz and M. Bashir and S. Karpf and R. Huber}, title = {{Ultra-high-accuracy chromatic dispersion measurement in optical fibers}}, volume = {11997}, booktitle = {Optical Components and Materials XIX}, editor = {Shibin Jiang and Michel J. F. Digonnet}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {119970L}, abstract = {The chromatic dispersion in optical fibers is a key property for applications where a broadband light source is used and the timing of each individual wavelength is crucial. Counteracting the timing offset introduced by the fiber is a challenge in many applications especially in mode locked lasers. The dispersion parameters need to be measured with high precision. The length of the fiber, the temperature, and the used wavelength will highly impact the amount of dispersion and the accuracy of the measurement. We developed an ultra-high-accuracy dispersion measurement setup at 1080 ± 50 nm considering all the parameters that may influence the measurement. It is based on a home-built wavelength tunable laser where the output is modulated by an electro-optical modulator connected to a 24 GSamples/s arbitrary waveform generator to a complex pattern consisting of pulses and a 4 GHz sine wave. After passing through the fiber the signal is measured with an 80 GSamples/s real time oscilloscope. The fiber’s temperature is controlled to allow for reproducible measurements over several days and we achieve timing measurement accuracies down to ~200 fs. We also present the performance of the setup at ~850 nm. We will discuss and quantify all effects which can negatively impact the system accuracy and we will report on more cost-effective options using lower performance equipment.}, keywords = {Dispersion measurement, Chromatic dispersion, fiber dispersion measurement, optical component characterization, tunable laser, FDML}, year = {2022}, doi = {10.1117/12.2608773}, URL = {https://doi.org/10.1117/12.2608773} } |
Özüm Emre
Aşırım,
Robert
Huber, and
Christian
Jirauschek,
Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers, in 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD) , 2022. pp. 67-68.
Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers, in 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD) , 2022. pp. 67-68.
DOI: | 10.1109/NUSOD54938.2022.9894816 |
Bibtex: | ![]() @INPROCEEDINGS{9894816, author={Aşırım, Ö. E. and Huber, R. and Jirauschek, C.}, booktitle={2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD)}, title={Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers}, year={2022}, volume={}, number={}, pages={67-68}, doi={10.1109/NUSOD54938.2022.9894816}} |
2021
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dec.2021. pp. EW1C.7.
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dec.2021. pp. EW1C.7.
DOI: | 10.1117/12.2616044 |
Bibtex: | ![]() @inproceedings{Strenge:21, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography}, pages = {EW1C.7}, publisher = {Optical Society of America}, title = {Comparison of two optical coherence tomography systems to identify human brain tumor}, year = {2021}, url = {https://doi.org/10.1117/12.2616044}, abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.}, } |
Madita
Göb,
Sazgar
Burhan,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dec.2021. pp. EW3C.4.
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dec.2021. pp. EW3C.4.
DOI: | 10.1117/12.2616054 |
Bibtex: | ![]() @inproceedings{Gob:21, author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber}, booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging}, pages = {EW3C.4}, publisher = {Optical Society of America}, title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4}, abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.}, } |
Nicolas
Detrez,
Katharina
Rewerts,
Moritz
Matthiae,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dec.2021. pp. EW4A.10.
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dec.2021. pp. EW4A.10.
Weblink: | https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10 |
Bibtex: | ![]() @inproceedings{Detrez:21, author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {EW4A.10}, publisher = {Optical Society of America}, title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography}, year = {2021}, url = {https://doi.org/10.1117/12.2615022}, abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.}, } |
Katharina
Rewerts,
Moritz
Matthiae,
Nicolas
Detrez,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dec.2021. pp. ETh3A.3.
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dec.2021. pp. ETh3A.3.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3 |
Bibtex: | ![]() @inproceedings{Rewerts2021ECBO, author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {ETh3A.3}, publisher = {Optical Society of America}, title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3}, abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.}, } |
Clara
Pfäffle,
Hendrik
Spahr,
Katharina
Gercke,
Sazan
Burhan,
David
Melenberg,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, Aug.2021.
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, Aug.2021.
DOI: | 10.1117/12.2577605 |
Bibtex: | ![]() @inproceedings{RN5321, author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer}, booktitle = {SPIE BiOS}, publisher = {SPIE}, volume = {11623}, url = {https://doi.org/10.1117/12.2577605}, type = {Conference Proceedings} } |
Philipp
Gruening,
Falk
Nette,
Noah
Heldt,
Ana Cristina Guerra
Souza, and
Erhardt
Barth,
Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning, in Proceedings of the Fourth Conference on Medical Imaging with Deep Learning , Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris, Eds. PMLR, Jul.2021. pp. 219--227.
Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning, in Proceedings of the Fourth Conference on Medical Imaging with Deep Learning , Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris, Eds. PMLR, Jul.2021. pp. 219--227.
Weblink: | https://proceedings.mlr.press/v143/gruening21a.html |
File: | gruening21a.html |
Bibtex: | ![]() @InProceedings{pmlr-v143-gruening21a, title = {Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning}, author = {Gruening, Philipp and Nette, Falk and Heldt, Noah and de Souza, Ana Cristina Guerra and Barth, Erhardt}, booktitle = {Proceedings of the Fourth Conference on Medical Imaging with Deep Learning}, pages = {219--227}, year = {2021}, editor = {Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris}, volume = {143}, series = {Proceedings of Machine Learning Research}, month = {07--09 Jul}, publisher = {PMLR}, pdf = {https://proceedings.mlr.press/v143/gruening21a/gruening21a.pdf}, url = {https://proceedings.mlr.press/v143/gruening21a.html}, abstract = {With in-line holography, it is possible to record biological cells over time in a three-dimensional hydrogel without the need for staining, providing the capability of observing cell behavior in a minimally invasive manner. However, this setup currently requires computationally intensive image-reconstruction algorithms to determine the required cell statistics. In this work, we directly extract cell positions from the holographic data by using deep neural networks and thus avoid several reconstruction steps. We show that our method is capable of substantially decreasing the time needed to extract information from the raw data without loss in quality.} } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Mark
Schmidt,
Wolfgang
Draxinger,
Jan Philip
Kolb,
Christian
Jirauschek, and
Robert
Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , Jun.2021. pp. 1-1.
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , Jun.2021. pp. 1-1.
DOI: | 10.1109/CLEO/Europe-EQEC52157.2021.9542126 |
Bibtex: | ![]() @INPROCEEDINGS{9542126, author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert}, booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Superposition of two independent FDML lasers}, year={2021}, volume={}, number={}, pages={1-1}, abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.}, keywords={}, doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126}, ISSN={}, month={June} } |
Tom
Pfeiffer,
Thomas
Klein,
Alexander
Mlynek,
Wolfgang
Wieser,
Simon
Lotz,
Christin
Grill, and
Robert
Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Jun.2021.
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, Jun.2021.
DOI: | 10.1117/12.2583501 |
Bibtex: | ![]() @inproceedings{Pfeiffer2021, author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber}, title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.}, keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2583501} } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, Mar.2021. pp. 242 -- 247.
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, Mar.2021. pp. 242 -- 247.
DOI: | 10.1117/12.2578293 |
Bibtex: | ![]() @inproceedings{Grill2021, author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {242 -- 247}, keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578293} } |