@inproceedings{Hillmann,
   author = {Hillmann, Dierck and Huttmann, Gereon and Koch, Peter},
   title = {Using nonequispaced fast Fourier transformation to process optical coherence tomography signals},
   editor = {Peter, E. Andersen and Brett, E. Bouma},
   publisher = {SPIE},
   volume = {7372},
   pages = {73720R},
url = { https://doi.org/10.1364/ECBO.2009.7372_0R},
year = { 2009}

}

@inproceedings{Schlott2009,
   author = {Schlott, Kerstin and Langejürgen, Jens and Bever, Marco and Koinzer, Stefan and Birngruber, Reginald and Brinkmann, Ralf},
   title = {Time resolved detection of tissue denaturation during retinal photocoagulation},
   editor = {7373, Proc. SPIE},
   pages = {73730E-73730E},
   note = {10.1117/12.831877},
   abstract = {The retinal photocoagulation is an established treatment method for different retinal diseases. The extent of the thermal coagulations depends strongly on the generated temperature increase. Until now the dosage is based on a pool of experience of the treating physicians as well as the appearance of the whitish lesions on the retina. The temperature course during photocoagulation can be measured in real-time by optoacoustics. A frequency-doubled Q-switched Nd:YLF laser (523nm, 75 ns) is used for optoacoustic excitation and a continuous-wave Nd:YAG laser (532nm) with adjustable irradiation time and power for heating of the fundus tissue. The onset of coagulation is determined by a photodiode that is placed directly behind enucleated porcine eyes, which served as a model. The onset of coagulation is observed clearly when scattering sets in. The required power for coagulation increases exponentially with decreasing irradiation time. The first results on rabbit eyes in vivo indicate that the onset of coagulation defined by just barely visibile lesions at a slit lamp sets in at an ED50 threshold temperature of 63°C for an irradiation time of 400 ms. In conclusion, optoacoustics can be used to determine temperatures during retinal laser treatments in real-time. This allows evaluating the time-temperature-dependence of retinal coagulation in vivo.},
   keywords = {AutoPhoN},
   url = {http://dx.doi.org/10.1117/12.831877},
   type = {Conference Proceedings},
year = { 2009},
url = { https://doi.org/10.1117/12.168030}
}

@inproceedings{Steven-2008,
   author = {Steven, Philip and Koop, Norbert and Huttmann, Gereon},
   title = {Confocal microscopy versus two-photon microscopy: imaging of ocular surface pathologies},
   editor = {Ammasi, Periasamy and Peter, T. C. So},
   publisher = {SPIE},
   volume = {6860},
   pages = {686023},
year = { 2008}
}

@inproceedings{Just-2008,
   author = {Just, T. and Lankenau, E. and Huettmann, G. and Pau, H.W.},
   title = {Optical coherence tomography as a guide for cochlear implant surgery},
   booktitle = {Progress in Biomedical Optics and Imaging},
   editor = {Nikiforos, K. and Bernard, C. and Haishan, Z.},
   publisher = {SPIE 6842},
   pages = {F1-F6},
url = { https://doi.org/10.1117/12.771446},
year = { 2008}

}

@inproceedings{Fritz2007,
   author = {Fritz, Andreas and Ptaszynski, Lars and Stoehr, Hardo and Brinkmann, Ralf},
   title = {Dynamics and detection of laser induced microbubbles in the retinal pigment epithelium (RPE)},
   volume = {6632},
   pages = {66321C-66321C-11},
   note = {10.1117/12.728344},
   abstract = {Selective Retina Treatment (SRT) is a new method to treat eye diseases associated with disorders of the RPE. Selective RPE cell damage is achieved by applying a train of 1.7 μs laser pulses at 527 nm. The treatment of retinal diseases as e.g. diabetic maculopathy (DMP), is currently investigated within clinical studies, however 200 ns pulse durations are under investigation. Transient micro bubbles in the retinal pigment epithelium (RPE) are expected to be the origin of cell damage due to irradiation with laser pulses shorter than 50 μs. The bubbles emerge at the strongly absorbing RPE melanosomes. Cell membrane disruption caused by the transient associated volume increase is expected to be the origin of the angiographically observed RPE leakage. We investigate micro bubble formation and dynamics in porcine RPE using pulse durations of 150 ns. A laser interferometry system at 830 nm with the aim of an online dosimetry control for SRT was developed. Bubble formation was detected interferometrically and by fast flash photography. A correlation to cell damage observed with a vitality stain is found. A bubble detection algorithm is presented.},
   url = {http://dx.doi.org/10.1117/12.728344},
   type = {Conference Proceedings}
}

@inproceedings{Stoehr2007-1,
   author = {Stoehr, Hardo and Ptaszynski, Lars and Fritz, Andreas and Brinkmann, Ralf},
   title = {Interferometric optical online dosimetry for selective retina treatment (SRT)},
   volume = {6426},
   pages = {642619-642619-7},
   note = {10.1117/12.708521},
   abstract = {In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.},
   url = {http://dx.doi.org/10.1117/12.708521},
   type = {Conference Proceedings},
Year = { 2007}
}

@inproceedings{Herrmann2007,
   author = {Herrmann, Katharina and Flöhr, Christian and Stalljohann, Jens and Apiou-Sbirlea, Gabriela and Kandulla, Jochen and Birngruber, Reginald and Brinkmann, Ralf},
   title = {Influence of choroidal perfusion on retinal temperature increase during retinal laser treatments},
   volume = {6632},
   pages = {66321D-66321D-7},
   note = {10.1117/12.728222},
   abstract = {In most retinal laser treatments the therapeutic effect is initiated by a transient temperature increase at and around the retinal pigment epithelium (RPE). Especially in long exposure time treatments like Transpupillary Thermotherapy (TTT) choroidal perfusion has a strong influence on the realized temperature at the fundus. The fundus blood circulation and therefore the heat dissipation is influenced by the intraocular pressure (IOP), which is investigated in the study presented here. In order to reduce the choroidal perfusion, the IOP is increased by injection of physiological saline solution into the eye of anaesthetized rabbits. The fundus is irradiated with 3.64 W/cm2 by means of a TTT-laser (λ = 810 nm) for t = 20 s causing a retinal temperature increase. Realtime temperature determination at the irradiated spot is achieved by a non invasive optoacoustic technique. Perfusion can be reduced by increasing IOP, which leads to different temperature increases when irradiating the retina. This should be considered for long time laser treatments.},
   url = {http://dx.doi.org/10.1117/12.728222},
   type = {Conference Proceedings},
year = { 2007}
}

@inproceedings{Theisen-Kunde2007,
   author = {Theisen-Kunde, D and Tedsen, S and Danicke, V and Herrmann, K and Brinkmann, R},
   title = {Partial kidney resection by use of a 1,94 µm thulium fiber laser},
   booktitle = {Proc ECBO},
   series = {Therapeutic Laser Applications and Laser-Tissue Interactions},
   publisher = {SPIE},
   volume = {6632},
   type = {Conference Proceedings},
year = { 2007},
url = { https://doi.org/10.1007/978-3-540-68764-1_72}
}

@inproceedings{Schlott2007,
   author = {Schlott, Kerstin and Stalljohann, Jens and Weber, Benjamin and Kandulla, Jochen and Herrmann, Katharina and Birngruber, Reginald and Brinkmann, Ralf},
   title = {Optoacoustic online temperature determination during retinal laser photocoagulation},
   volume = {6632},
   pages = {66321B-66321B-8},
   note = {10.1117/12.728291},
   abstract = {Retinal photocoagulation is an established treatment of different retinal diseases. The treatment relies on a short, local heating of the tissue which induces a denaturation. The resulting scar formation may for example prevent the further detachment of the retina. The extent of the coagulation is besides other parameters mostly dependent on the induced temperature increase. However, until today a temperature based dosimetry for photocoagulation does not exist. The dosage is rather based on the experience of the treating physicians to achieve visible whitish lesions on the retina. In this work a technique is presented, which allows an online temperature monitoring during photocoagulation. If an absorbing material is irradiated with short laser pulses, a thermoelastic expansion of the absorber induces an acoustic wave. Its amplitude is dependent on the temperature of the absorber. For analyzing the applicability of the optoacoustic temperature determination for dosimetry, measurements were performed on enucleated porcine eye globes. The pressure transients are detected by an ultrasonic transducer, which is embedded in an ophthalmologic contact lens. As long as no strong lesions occur, the determined temperatures are almost proportional to the power of the treatment laser. Using a spot diameter of 200 μm and different laser powers, the temperature rise at the end of the 400 ms irradiation was found to be approximately 0.16 °C/mW. The onset of the denaturation was observed around 50°C. The far aim of this project is an automatic regulation of the treatment laser onto a desired temperature course.},
   url = {http://dx.doi.org/10.1117/12.728291},
   type = {Conference Proceedings},
year = { 2007}
}

@inproceedings{Qu2007,
   author = {Qu, Xiaochao and Norbert, Koop and Li, Zheng and Wang, Jing and Zhang, Zhenxi and Hüttmann, Gereon},
   title = {Multiphoton fluorescence lifetime imaging of Karpas 299 cells using ACT1 antibody conjugated gold nanoparticles},
   volume = {6630},
   pages = {66301C-66301C-8},
   note = {10.1117/12.728239},
   abstract = {Due to the unique optical properties, gold nanoparticles (NPs) can play a useful role in biological cellular imaging as biological probes. Using multiphoton microscopy and fluorescence lifetime imaging (FLIM) system, we recorded the images of Karpas 299 cells incubated without, or with gold NPs, and ACT1 antibodies conjugated with gold NPs. From the FLIM, we can easily discriminate the difference among different experiment conditions due to the distinct lifetime between cells and gold NPs. Our results present that nonconjugated gold NPs are accumulated inside cells, but conjugated gold NPs bind homogeneously and specifically to the surface of cancer cells. For single Karpas 299 cells, the signal is very week when the excitation power is about 10mw; while the power is approximately 28 mw, a very sharp cell imaging can be obtained. For the Karpas 299 incubated with ACT1 conjugated gold NPs, while the excitation power is 10mw, gold NPs have clear fluorescence signal so that the profile of cells can be detected; Signal of gold NPs is very strong when the power arrived in 20mw. These results suggest that the multiphoton lifetime imaging of antibody conjugated gold NPs can support a useful method in diagnosis of cancer.},
   url = {http://dx.doi.org/10.1117/12.728239},
   type = {Conference Proceedings},
year = { 2007}
}

@inproceedings{Kandulla2006,
   author = {Kandulla, J and Elsner, H and Sandeau, J and Birngruber, R and Brinkmann, R},
   title = {Non-invasive optoacoustic temperature determination during retinal cw-laser treatments},
   booktitle = {Proc SPIE},
   volume = {6138},
   pages = {336-343},
   type = {Conference Proceedings},
year = { 2006},
url = { https://doi.org/10.1117/12.674409}
}

@inproceedings{Vogel-2006,
   author = {Vogel, A. and Noack, J. and Hüttmann, G. and Linz, N. and Freidank, S. and Paltauf, G.},
   title = {Femtosecond laser nanosurgery of biological cells and tissues},
   booktitle = {4th International Congress on Laser Advanced Materials Processing},
Year = { 2006},
URL = { http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.713.4169&rep=rep1&type=pdf}
}

@inproceedings{Sandeau2006,
   author = {Sandeau, Julien and Caillibotte, Georges and Kandulla, Jochen and Birngruber, Reginald and Apiou-Sbirlea, Gabriela},
   title = {Modeling of conductive and convective heat transfers in retinal laser treatments},
   volume = {6138},
   pages = {61381A-61381A-9},
   note = {10.1117/12.673494},
   abstract = {Tumor thermo treatment such as photodynamic therapy (PDT) or transpupillary thermotherapy (TTT) deal with long term and large laser spot exposures. The induced temperature increase is not exactly known [1]. Under these conditions convective heat transfers due to the blood flow in the choroid and the choriocapillaris must be considered in addition to the usually calculated heat conduction. From an existing analytical model defining a unique convective term for the whole fundus irradiated with Gaussian irradiance distribution lasers [2], we developed a numerical one allowing a precise modelling of convection and calculating heating evolution and temperature profiles of the fundus of the eye. The aim of this study is to present the modelling and several comparisons between experimental results [3] and numerical ones concerning the convective heat transfers inside the fundus of the eye.},
   url = {http://dx.doi.org/10.1117/12.673494},
   type = {Conference Proceedings},
year = { 2006}
}

@inproceedings{Horneffer,
   author = {Horneffer, V. and Vogel, A. and Sägmüller, B. and Schütze, K.},
   title = {Microdissection, catapulting, and microinjection of biologic specimens with femtosecond laser pulses},
   booktitle = {SPIE/OSA Conference on Biomedical Optics ECBO,12.-16.06.2005},

}

@inproceedings{Kandulla2005,
   author = {Kandulla, J and Elsner, H and Hilmes, M and Hartert, C and Brinkmann, R},
   title = {Optoacoustic temperature determination at the fundus of the eye during Transpupillary Thermotherapy},
   booktitle = {Proc SPIE},
   volume = {5688},
   pages = {208-214},
   keywords = {AutoPhoN},
   type = {Conference Proceedings},
url = { https://doi.org/10.1117/12.608406},
year = { 2005}
}

@inproceedings{Daniltchenko,
   author = {Daniltchenko, D. and Sachs, M. and Lankenau, E. and König, F. and Burckhardt, M. and Hüttmann, G. and Kristiansen, G. and Schnorr, D. and Al-Shukri, S. and Löning, S.},
   title = {Ex vivo and in vivo topographics studies of bladder by optical coherence tomography},
   booktitle = {Saratov Fall Meeting 2004: Optical Technologies in Biophysics and Medicine VI},
   editor = {Tuchin, V.},
   publisher = {Proceedings 2005},
   volume = {5771},
   pages = {209-14},
year = { 2005},
URL = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/5771/0000/Ex-vivo-and-in-vivo-topographic-studies-of-bladder-by/10.1117/12.634810.short}

}

@inproceedings{Framme-2004,
   author = {Framme, C. and Alt, C. and Schnell, S. and Brinkmann, R. and Lin, C. P.},
   title = {Selektive RPE-Behandlung (SRT) durch Laserscanning eines CW- Lasers},
   booktitle = {102nd Congress Deutsche Ophthalmologische Gesellschaft},
year = { 2004}

}

@inproceedings{Lankenau,
   author = {Lankenau, E. and Schumacher, M. and Koch, P. and König, F. and Daniltchenko, D. and Schmorr, D. and Hüttmann, G.},
   title = {Dispersion compensation for proximal scanning rigid OCT endoscopes},
   booktitle = {SPIE Proc.},
   volume = {5316},
   pages = {172-177},
Year = { 2004},
URL = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/5316/0000/Dispersion-compensation-for-proximal-scanning-rigid-OCT-endoscopes/10.1117/12.531312.short}

}

@inproceedings{Koch-2004,
   author = {Koch, Peter and Huettmann, Gereon and Schleiermacher, Hansfrieder and Eicholz, Joerg and Koch, Edmund},
   title = {Linear OCT system with down conversion of the fringe pattern},
   editor = {Valery, V. Tuchin and Joseph, A. Izatt and James, G. Fujimoto},
   publisher = {SPIE},
   volume = {5316},
   pages = {260-267},
Year = { 2004},
URL = { https://doi.org/10.1117/12.531323}

}

@inproceedings{Apitz-2003,
   author = {Apitz, Ingo and Vogel, Alfred},
   title = {Material ejection in Q-switched Er:YAG laser ablation of water, liver, and skin},
   editor = {Steven, L. Jacques and Donald, D. Duncan and Sean, J. Kirkpatrick and Andres, Kriete},
   publisher = {SPIE},
   volume = {4961},
   pages = {48-59},
URL = { https://doi.org/10.1117/12.477707},
year = { 2003}
}

@inproceedings{Vogel-2003,
   author = {Vogel, Alfred and Venugopalan, Vasan},
   title = {Kinetics of phase transitions in pulsed IR laser ablation of biological tissues},
   editor = {Steven, L. Jacques and Donald, D. Duncan and Sean, J. Kirkpatrick and Andres, Kriete},
   publisher = {SPIE},
   volume = {4961},
   pages = {66-74},
year = { 2003}
}

@inproceedings{Hüttmann2003,
   author = {Huettmann, Gereon and Radt, Benno and Serbin, Jesper and Birngruber, Reginald},
   title = {Inactivation of proteins by irradiation of gold nanoparticles with nano- and picosecond laser pulses},
   editor = {Rudolf, W. Steiner},
   publisher = {SPIE},
   volume = {5142},
   pages = {88-95},
URL = { https://doi.org/10.1364/ECBO.2003.5142_88},
year = { 2003}
}

@inproceedings{Alt2002,
   author = {Alt, C and Framme, C and Schnell, S and Schuele, G and Brinkmann, R and Lin, C P},
   title = {In vivo and in vitro Selective Targeting of the Retinal Pigment Epithelium (RPE) Using a Laser-Scanning Device},
   booktitle = {Proc SPIE},
   volume = {4611},
   pages = {59-63},
   type = {Conference Proceedings},
URL = { https://doi.org/10.1117/12.470607},
year = { 2002}
}

@inproceedings{Schuele-2002,
   author = {Schuele, Georg and Huettmann, Gereon and Brinkmann, Ralf},
   title = {Noninvasive temperature measurements during laser irradiation of the retina with optoacoustic techniques},
   editor = {Fabrice, Manns and Per, G. Soederberg and Arthur, Ho},
   publisher = {Proc. SPIE},
   volume = {4611},
   pages = {64-71},
year = { 2002},
url = { https://doi.org/10.1117/12.470601} 
}

@inproceedings{Vogel2001,
   author = {Vogel, Alfred and Brujan, Emil A and Schmidt, Peter and Nahen, Kester},
   title = {Interaction of Laser-Produced Cavitation Bubbles with Elastic Boundaries},
   booktitle = {IUTAM Symposium on Free Surface Flows},
   publisher = {Springer},
   pages = {327-335},
   ISBN = {9401038546},
   type = {Conference Proceedings},
year = { 2001}
}