2024
Sebastian
Karpf,
Nina
Glöckner Burmeister,
Laurence
Dubreil,
Shayantani
Ghosh,
Reka
Hollandi,
Julien
Pichon,
Isabelle
Leroux,
Alessandra
Henkel,
Valerie
Lutz,
Jonas
Jurkevičius,
Alexandra
Latshaw,
Vasyl
Kilin,
Tonio
Kutscher,
Moritz
Wiggert,
Oscar
Saavedra-Villanueva,
Alfred
Vogel,
Robert
Huber,
Peter
Horvath,
Karl
Rouger, and
Luigi
Bonacina,
Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate, Small , pp. 2401472, 06 2024.
Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate, Small , pp. 2401472, 06 2024.
DOI: | https://doi.org/10.1002/smll.202401472 |
Bibtex: | ![]() @article{https://doi.org/10.1002/smll.202401472, author = {Karpf, Sebastian and Glöckner Burmeister, Nina and Dubreil, Laurence and Ghosh, Shayantani and Hollandi, Reka and Pichon, Julien and Leroux, Isabelle and Henkel, Alessandra and Lutz, Valerie and Jurkevičius, Jonas and Latshaw, Alexandra and Kilin, Vasyl and Kutscher, Tonio and Wiggert, Moritz and Saavedra-Villanueva, Oscar and Vogel, Alfred and Huber, Robert A. and Horvath, Peter and Rouger, Karl and Bonacina, Luigi}, title = {Harmonic Imaging of Stem Cells in Whole Blood at GHz Pixel Rate}, journal = {Small}, volume = {n/a}, number = {n/a}, pages = {2401472}, keywords = {fiber lasers, harmonic imaging, multiphoton microscopy, nanoparticles, regenerative medicine, SHG, SLIDE}, doi = {https://doi.org/10.1002/smll.202401472}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.202401472}, eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/smll.202401472}, abstract = {Abstract The pre-clinical validation of cell therapies requires monitoring the biodistribution of transplanted cells in tissues of host organisms. Real-time detection of these cells in the circulatory system and identification of their aggregation state is a crucial piece of information, but necessitates deep penetration and fast imaging with high selectivity, subcellular resolution, and high throughput. In this study, multiphoton-based in-flow detection of human stem cells in whole, unfiltered blood is demonstrated in a microfluidic channel. The approach relies on a multiphoton microscope with diffractive scanning in the direction perpendicular to the flow via a rapidly wavelength-swept laser. Stem cells are labeled with metal oxide harmonic nanoparticles. Thanks to their strong and quasi-instantaneous second harmonic generation (SHG), an imaging rate in excess of 10 000 frames per second is achieved with pixel dwell times of 1 ns, a duration shorter than typical fluorescence lifetimes yet compatible with SHG. Through automated cell identification and segmentation, morphological features of each individual detected event are extracted and cell aggregates are distinguished from isolated cells. This combination of high-speed multiphoton microscopy and high-sensitivity SHG nanoparticle labeling in turbid media promises the detection of rare cells in the bloodstream for assessing novel cell-based therapies.} } |
Noah
Heldt,
Cornelia
Holzhausen,
Martin
Ahrens,
Mario
Pieper,
Peter
König, and
Gereon
Huettmann,
Reducing dOCT imaging time, in Abstract Book 12th DZL Annual Meeting , Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 062024. pp. 399.
Reducing dOCT imaging time, in Abstract Book 12th DZL Annual Meeting , Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 062024. pp. 399.
Weblink: | https://dzl.de/wp-content/uploads/2024/06/DZL2024_Abstract_Book-1.pdf |
Datei: |
Simon
Lotz,
Madita
Göb,
Sven
Böttger,
Linh
Ha-Wissel,
Jennifer
Hundt,
Floris
Ernst, and
Robert
Huber,
Large area robotically assisted optical coherence tomography (LARA-OCT), Biomed. Opt. Express , vol. 15, no. 6, pp. 3993-4009, 06 2024. Optica Publishing Group.
Large area robotically assisted optical coherence tomography (LARA-OCT), Biomed. Opt. Express , vol. 15, no. 6, pp. 3993-4009, 06 2024. Optica Publishing Group.
DOI: | 10.1364/BOE.525524 |
Bibtex: | ![]() @article{Lotz:24, author = {Simon Lotz and Madita G\"{o}b and Sven B\"{o}ttger and Linh Ha-Wissel and Jennifer Hundt and Floris Ernst and Robert Huber}, journal = {Biomed. Opt. Express}, keywords = {Angiography; Biomedical imaging; In vivo imaging; Machine vision; Point clouds; Spectral domain optical coherence tomography}, number = {6}, pages = {3993--4009}, publisher = {Optica Publishing Group}, title = {Large area robotically assisted optical coherence tomography (LARA-OCT)}, volume = {15}, month = {Jun}, year = {2024}, url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-6-3993}, doi = {10.1364/BOE.525524}, abstract = {We demonstrate large-area robotically assisted optical coherence tomography (LARA-OCT), utilizing a seven-degree-of-freedom robotic arm in conjunction with a 3.3\&\#x2005;MHz swept-source OCT to raster scan samples of arbitrary shape. By combining multiple fields of view (FOV), LARA-OCT can probe a much larger area than conventional OCT. Also, nonplanar and curved surfaces like skin on arms and legs can be probed. The lenses in the LARA-OCT scanner with their normal FOV can have fewer aberrations and less complex optics compared to a single wide field design. This may be especially critical for high resolution scans. We directly use our fast MHz-OCT for tracking and stitching, making additional machine vision systems like cameras, positioning, tracking or navigation devices obsolete. This also eliminates the need for complex coordinate system registration between OCT and the machine vision system. We implemented a real time probe-to-surface control that maintains the probe alignment orthogonal to the sample by only using surface information from the OCT images. We present OCT data sets with volume sizes of 140\&\#x2009;\&\#x00D7;\&\#x2009;170\&\#x2009;\&\#x00D7;\&\#x2009;20 mm3, captured in 2.5 minutes.}, } |
L.
Ha-Wissel,
H.
Graßhoff,
M.
Göb,
B.
Mustafa,
R.
Huber,
H.
Zirpel,
H.
Yasak,
D.
Thaçi, and
J. E.
Hundt,
Optical coherence tomography-based imaging biomarkers for disease activity monitoring in plaque psoriasis, Journal of the European Academy of Dermatology and Venereology , vol. n/a, no. n/a, 05 2024.
Optical coherence tomography-based imaging biomarkers for disease activity monitoring in plaque psoriasis, Journal of the European Academy of Dermatology and Venereology , vol. n/a, no. n/a, 05 2024.
DOI: | https://doi.org/10.1111/jdv.20097 |
Datei: | jdv.20097 |
Bibtex: | ![]() @article{https://doi.org/10.1111/jdv.20097, author = {Ha-Wissel, L. and Graßhoff, H. and Göb, M. and Mustafa, B. and Huber, R. and Zirpel, H. and Yasak, H. and Thaçi, D. and Hundt, J. E.}, title = {Optical coherence tomography-based imaging biomarkers for disease activity monitoring in plaque psoriasis}, journal = {Journal of the European Academy of Dermatology and Venereology}, volume = {n/a}, number = {n/a}, pages = {}, doi = {https://doi.org/10.1111/jdv.20097}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.20097}, eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1111/jdv.20097} } |
Rene
Riha,
Alejandro Martinez
Jimenez,
Gopika
Venugopal,
Marie
Klufts,
Robert
Huber, and
Adrian
Podoleanu,
Dispersion-Tuned Mode-Locked Laser for Swept Source OCT At 850 Nm Using a cFBG and the Pulse Modulation Technique, IEEE Photonics Journal , pp. 1-6, Mai 2024.
Dispersion-Tuned Mode-Locked Laser for Swept Source OCT At 850 Nm Using a cFBG and the Pulse Modulation Technique, IEEE Photonics Journal , pp. 1-6, Mai 2024.
DOI: | 10.1109/JPHOT.2024.3417829 |
Bibtex: | ![]() @ARTICLE{10568460, author={Riha, Rene and Jimenez, Alejandro Martinez and Venugopal, Gopika and Klufts, Marie and Huber, Robert and Podoleanu, Adrian}, journal={IEEE Photonics Journal}, title={Dispersion-Tuned Mode-Locked Laser for Swept Source OCT At 850 Nm Using a cFBG and the Pulse Modulation Technique}, year={2024}, volume={}, number={}, pages={1-6}, keywords={Modulation;Dispersion;Semiconductor optical amplifiers;Optical interferometry;Optical pulses;Frequency modulation;Optical fiber amplifiers;OCT;dispersion tuning;cFBG;intensity modulator}, doi={10.1109/JPHOT.2024.3417829}} |
Claus
Burchard,
Christopher
Kren,
Jan-Erik
Fleger,
Dirk
Theisen-Kunde,
Veit
Danicke,
Hossam S.
Abbas,
Viktoria
Kleyman,
Johann
Roider, and
Ralf
Brinkmann,
Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits, Translational Vision Science & Technology , vol. 13, no. 4, pp. 26-26, 04 2024.
Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits, Translational Vision Science & Technology , vol. 13, no. 4, pp. 26-26, 04 2024.
DOI: | 10.1167/tvst.13.4.26 |
Datei: | tvst.13.4.26 |
Bibtex: | ![]() @article{10.1167/tvst.13.4.26, author = {von der Burchard, Claus and Kren, Christopher and Fleger, Jan-Erik and Theisen-Kunde, Dirk and Danicke, Veit and Abbas, Hossam S. and Kleyman, Viktoria and Roider, Johann and Brinkmann, Ralf}, title = "{Real-Time Temperature-Controlled Retinal Laser Irradiation in Rabbits}", journal = {Translational Vision Science & Technology}, volume = {13}, number = {4}, pages = {26-26}, year = {2024}, month = {04}, abstract = "{ Subdamaging thermal retinal laser therapy has the potential to induce regenerative stimuli in retinal diseases, but validated dosimetry is missing. Real-time optoacoustic temperature determination and control could close this gap. This study investigates a first in vivo application. Two iterations of a control module that were optically coupled in between a continuous-wave commercial laser source and a commercial slit lamp were evaluated on chinchilla rabbits. The module allows extraction of the temperature rise in real time and can control the power of the therapy laser such that a predefined temperature rise at the retina is quickly achieved and held constant. Irradiations with aim temperatures from 45°C to 69°C were performed on a diameter of 200 µm and a heating time of 100 ms. We analyzed 424 temperature-guided irradiations in nine eyes of five rabbits. The mean difference between the measured and aim temperature was −0.04°C ± 0.98°C. The following ED50 values for visibility thresholds could be determined: 58.6°C for funduscopic visibility, 57.7°C for fluorescein angiography, and 57.0°C for OCT. In all measurements, the correlation of tissue effect was higher to the temperature than to the average heating laser power used. The system was able to reliably perform temperature-guided irradiations, which allowed for better tissue effect control than simple power control. This approach could enhance the accuracy, safety, and reproducibility of thermal stimulating laser therapy. This study is a bridge between preclinical ex vivo experiments and a pilot clinical study. }", issn = {2164-2591}, doi = {10.1167/tvst.13.4.26}, url = {https://doi.org/10.1167/tvst.13.4.26}, eprint = {https://arvojournals.org/arvo/content\_public/journal/tvst/938671/i2164-2591-13-4-26\_1713518675.19154.pdf}, } |
Alexander
Altmann,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Assessing food degradation and microbial growth by sensor read-out with fluorescence spectroscopy, in Frontiers in Biological Detection: From Nanosensors to Systems XVI , Amos Danielli and Benjamin L. Miller and Sharon M. Weiss, Eds. SPIE, 032024. pp. 128610A.
Assessing food degradation and microbial growth by sensor read-out with fluorescence spectroscopy, in Frontiers in Biological Detection: From Nanosensors to Systems XVI , Amos Danielli and Benjamin L. Miller and Sharon M. Weiss, Eds. SPIE, 032024. pp. 128610A.
DOI: | 10.1117/12.3000908 |
Bibtex: | ![]() @inproceedings{10.1117/12.3000908, author = {Alexander Altmann and Christian Schell and Ramtin Rahmanzadeh}, title = {{Assessing food degradation and microbial growth by sensor read-out with fluorescence spectroscopy}}, volume = {12861}, booktitle = {Frontiers in Biological Detection: From Nanosensors to Systems XVI}, editor = {Amos Danielli and Benjamin L. Miller and Sharon M. Weiss}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {128610A}, abstract = {Both the waste of edible food and the consumption of non-edible food within the best before date are ongoing concerns in food industry. Until now, no methods are applied to access food quality of packed food without opening of packages. We demonstrate the formulation of a sensor foil comprising of a non-toxic porphyrin on an inorganic matrix in polyethylene. The sensor foil is capable of detecting amines in the gas phase over food products, which could act as spoilage indicators during the shelf life of packaged food. The foil was optimized to prevent reactions with other analytes in the gas phase of food by the alteration of the hydrophobic polymer. We performed experiments, using model packing units, to monitor the behavior of the foil and correlated the change in the fluorescence spectra to the total viable count of bacteria on the fish. The readout of the foils was performed with fluorescence spectroscopy to yield highly accurate results in contrast to less accurate the colorimetric determination.}, keywords = {fluorescence spectroscopy, gas sensing, amine sensor, food safety, porphyrins}, year = {2024}, doi = {10.1117/12.3000908}, URL = {https://doi.org/10.1117/12.3000908} } |
Alexander
Altmann,
Mohammad
Khodaygani,
Martin
Leucker,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Detection of spoiled food along the supply chain with novel sensors for packed food, in Photonic Technologies in Plant and Agricultural Science , Dag Heinemann and Gerrit Polder, Eds. SPIE, 032024. pp. 1287906.
Detection of spoiled food along the supply chain with novel sensors for packed food, in Photonic Technologies in Plant and Agricultural Science , Dag Heinemann and Gerrit Polder, Eds. SPIE, 032024. pp. 1287906.
DOI: | 10.1117/12.3000912 |
Bibtex: | ![]() @inproceedings{10.1117/12.3000912, author = {Alexander Altmann and Mohammad Khodaygani and Martin Leucker and Christian Schell and Ramtin Rahmanzadeh}, title = {{Detection of spoiled food along the supply chain with novel sensors for packed food}}, volume = {12879}, booktitle = {Photonic Technologies in Plant and Agricultural Science}, editor = {Dag Heinemann and Gerrit Polder}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1287906}, abstract = {Along food supply chains, several critical steps can lead to inconsumable food. Especially food of animal origin undergoes rapid aging, when stored inadequately. Quality assessment of packaged food products faces serious problems ranging from the loss of integrity of the package to damage of the food and it is applied only to a low number of samples per batch. As a result, food products are either wasted or not analyzed, which results in a significant decrease in food safety. As a part of an intelligent packaging system, we designed a sensor foil that can detect amines, produced during the food aging process. Change of the fluorescence of the sensor foil can be assessed with spectroscopy or color change from green to red can be detected optically with a camera, e.g. by smartphone. The foil can be incorporated inside the single packaging units and noninvasively measured routinely by the store or consumer. The readout of the foils was performed with steady-state tabletop spectrometers, which were then compared to the results for readouts with different inexpensive handheld devices that could be used during real-life applications, e.g., at any step in a food supply chain. Ideally, the single food product is linked to a single foil at the primary producer, measuring the first spectrum and connecting the data to the specific product, e.g. via distributed ledger. For a transparent process chain, QR-codes could be utilized to allow access to the freshness data along the shelf life of a single package. }, keywords = {fluorescence spectroscopy, gas sensing, amine sensor, food safety, porphyrins, SVM classifier, block chain, non-destructive food testing}, year = {2024}, doi = {10.1117/12.3000912}, URL = {https://doi.org/10.1117/12.3000912} } |
Mark
Ellrichmann,
Berenice
Schulte,
Claudio C
Conrad,
Stephan
Schoch,
Johannes
Bethge,
Marcus
Seeger,
Robert
Huber,
Madita
Göb,
Alexander
Arlt,
Susanna
Nikolaus,
Christoph
Röcken, and
Stefan
Schreiber,
Contrast enhanced endoscopic ultrasound detects early therapy response following anti-TNF-therapy in patients with ulcerative colitis, Journal of Crohn's and Colitis , pp. jjae034, 03 2024.
Contrast enhanced endoscopic ultrasound detects early therapy response following anti-TNF-therapy in patients with ulcerative colitis, Journal of Crohn's and Colitis , pp. jjae034, 03 2024.
DOI: | 10.1093/ecco-jcc/jjae034 |
Bibtex: | ![]() @article{10.1093/ecco-jcc/jjae034, author = {Ellrichmann, Mark and Schulte, Berenice and Conrad, Claudio C and Schoch, Stephan and Bethge, Johannes and Seeger, Marcus and Huber, Robert and Goeb, Madita and Arlt, Alexander and Nikolaus, Susanna and Röcken, Christoph and Schreiber, Stefan}, title = "{Contrast enhanced endoscopic ultrasound detects early therapy response following anti-TNF-therapy in patients with ulcerative colitis}", journal = {Journal of Crohn's and Colitis}, pages = {jjae034}, year = {2024}, month = {03}, abstract = "{Though colonoscopy plays a crucial role in assessing active ulcerative colitis (aUC), its scope is limited to the mucosal surface. Endoscopic ultrasound (EUS) coupled with contrast-enhancement (dCEUS) can precisely quantify bowel wall thickness and microvascular circulation, potentially enabling the quantitative evaluation of inflammation.We conducted a prospective, longitudinal study to assess therapy response using dCEUS in aUC patients undergoing treatment with adalimumab (ADA) or infliximab (IFX).30 ADA- and 15 IFX-treated aUC patients were examined at baseline and at 2, 6, 14 weeks of therapy and 48 weeks of follow-up. Bowel wall thickness (BWT) was measured by EUS in the rectum. Vascularity was quantified by dCEUS using Rise Time (RT) and Time To Peak (TTP). Therapy response was defined after 14 weeks using the Mayo Score.Patients with aUC displayed a mean BWT of 3.9±0.9 mm. In case of response to ADA/IFX a significant reduction in BWT was observed after 2 weeks (p=0.04), whereas non-responders displayed no significant changes. The TTP was notably accelerated at baseline and significantly normalised by week 2 in responders (p=0.001), while non-responders exhibited no significant alterations (p=0.9). At week 2, the endoscopic Mayo score did not exhibit any changes, thus failing to predict treatment responses.dCEUS enables the early detection of therapy response in patients with aUC, which serves as a predictive marker for long term clinical success. Therefore, dCEUS serves as a diagnostic tool for assessing the probability of future therapy success.}", issn = {1873-9946}, doi = {10.1093/ecco-jcc/jjae034}, url = {https://doi.org/10.1093/ecco-jcc/jjae034}, eprint = {https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjae034/56911128/jjae034.pdf}, } |
Berenice
Schulte,
Madita
Göb,
Awanish Pratap
Singh,
Simon
Lotz,
Wolfgang
Draxinger,
Mario
Pieper,
Maik
Rahlves,
Robert
Huber, and
Mark
Ellrichmann,
High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy, Scientific Reports , vol. 14, no. 1, pp. 4672, 02 2024.
High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy, Scientific Reports , vol. 14, no. 1, pp. 4672, 02 2024.
DOI: | 10.1038/s41598-024-55338-5 |
Bibtex: | ![]() @article{RN5474, author = {Schulte, Berenice;Göb, Madita;Singh, Awanish Pratap;Lotz, Simon;Draxinger, Wolfgang;Heimke, Marvin;pieper, Mario;Heinze, Tillmann;Wedel, Thilo;Rahlves, Maik;Huber, Robert and Ellrichmann, Mark}, title = {High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy}, journal = {Scientific Reports}, volume = {14}, number = {1}, pages = {4672}, ISSN = {2045-2322}, DOI = {10.1038/s41598-024-55338-5}, url = {https://doi.org/10.1038/s41598-024-55338-5}, year = {2024}, type = {Journal Article} } |
Jessica
Kren,
Patrick
Kuppler,
Steffen
Buschschlüter,
Nicolas
Detrez,
Sazgar
Burhan,
Robert
Huber,
Ralf
Brinkmann, and
Matteo Mario
Bonsanto,
Mechanical characteristics of glioblastoma and peritumoral tumor-free human brain tissue, Acta Neurochirurgica , vol. 166, no. 1, pp. 102, 02 2024.
Mechanical characteristics of glioblastoma and peritumoral tumor-free human brain tissue, Acta Neurochirurgica , vol. 166, no. 1, pp. 102, 02 2024.
DOI: | 10.1007/s00701-024-06009-x |
Bibtex: | ![]() @article{RN5472, author = {Kren, Jessica;Skambath, Isabelle;Kuppler, Patrick;Buschschlüter, Steffen;Detrez, Nicolas;Burhan, Sazgar;Huber, Robert;Brinkmann, Ralf and Bonsanto, Matteo Mario}, title = {Mechanical characteristics of glioblastoma and peritumoral tumor-free human brain tissue}, journal = {Acta Neurochirurgica}, volume = {166}, number = {1}, pages = {102}, ISSN = {0942-0940}, DOI = {10.1007/s00701-024-06009-x}, url = {https://doi.org/10.1007/s00701-024-06009-x}, year = {2024}, type = {Journal Article} } |
Clemens A.
Lange,
Charlotte
Ohlmeier,
Anna
Kiskämper,
Christoph
Schwarzkopf,
Hinrich
Hufnagel,
Markus
Gruber,
Benedikt
Schworm,
Ulrike
Brocks,
Franziska
Reinking,
Lisa
Schreiner,
Yoko
Miura,
Milena
Grundel,
Tibor
Lohmann,
Christoph R.
Clemens,
Maria-Andreea
Gamulescu,
Nicole
Eter,
Salvatore
Grisanti,
Siegfried
Priglinger,
Martin S.
Spitzer,
Peter
Walter,
Hansjürgen A.
Agostini,
Andreas
Stahl,
Laurenz J.B.
Pauleikhoff, and
Retina.net CSC-Registry-Study Group,
Clinical Landscape of Central Serous Chorioretinopathy in Germany: Retina.net CSC Registry Report Number 1, Ophthalmologica , pp. 1-12, 02 2024.
Clinical Landscape of Central Serous Chorioretinopathy in Germany: Retina.net CSC Registry Report Number 1, Ophthalmologica , pp. 1-12, 02 2024.
DOI: | 10.1159/000535930 |
Datei: | 000535930 |
Bibtex: | ![]() @article{10.1159/000535930, author = {Lange, Clemens A. and Ohlmeier, Charlotte and Kiskämper, Anna and von Schwarzkopf, Christoph and Hufnagel, Hinrich and Gruber, Markus and Schworm, Benedikt and Brocks, Ulrike and Reinking, Franziska and Schreiner, Lisa and Miura, Yoko and Grundel, Milena and Lohmann, Tibor and Clemens, Christoph R. and Gamulescu, Maria-Andreea and Eter, Nicole and Grisanti, Salvatore and Priglinger, Siegfried and Spitzer, Martin S. and Walter, Peter and Agostini, Hansjürgen A. and Stahl, Andreas and Pauleikhoff, Laurenz J.B. and for the Retina.net CSC-Registry-Study Group}, title = "{Clinical Landscape of Central Serous Chorioretinopathy in Germany: Retina.net CSC Registry Report Number 1}", journal = {Ophthalmologica}, pages = {1-12}, year = {2024}, month = {02}, abstract = "{Introduction: The German Registry of central serous chorioretinopathy (CSC) collects data on CSC patients in a nationwide multicenter approach to analyze epidemiology, risk factors, clinical presentations, as well as diagnosis and treatment patterns. Methods: In this multicenter cohort study, patients with CSC were enrolled in nine tertiary referral centers in Germany between January 2022 and June 2023. After consenting to the study, demographic data, risk factors, reported symptoms, best-corrected visual acuity (BCVA), funduscopic findings, disease severity, and diagnostic and treatment decisions were recorded and analyzed. Results: A total of 539 eyes of 411 CSC patients were enrolled in this study including 308 males (75\\%) and 103 females (25\\%). Patients were predominantly of Caucasian origin and had a mean age of 55.5 years (IQR 41.0–70.0). 28\\% of eyes were classified as acute (\\<4 months duration) CSC, 28\\% as chronic (\\>4 months duration) CSC, 21\\% as inactive CSC, 11\\% as chronic atrophic CSC, and 12\\% as CSC with secondary CNV. 128 patients (31\\%) demonstrated bilateral CSC. The most common risk factors reported were psychological stress (52\\%), smoking (38\\%), arterial hypertension (38\\%), and a history of or current use of steroids (30\\%). Most frequently encountered symptoms included decreased visual acuity (76\\%), metamorphopsia (49\\%), relative scotoma (47\\%), blurred vision (19\\%), and dyschromatopsia (9\\%). The mean logMAR BCVA on initial examination was 0.2 (≈20/30, IQR 0.2–0.4) but showed significant variation with a tendency of lower BCVA in chronic cases. At the baseline visit, 74\\% of the overall cohort received no treatment, while 19\\% underwent local treatment and only 2\\% underwent systemic treatment. Of the local therapies, anti-VEGF injections were the most frequently performed procedure (33\\%, mainly for secondary CNV), followed by micropulse laser (28\\%), focal nonpulsed laser (23\\%), verteporfin photodynamic therapy (14\\%), and nonsteroidal anti-inflammatory eye drops (2\\%). Among intravitreal anti-VEGF agents, aflibercept was used most frequently, followed by bevacizumab and ranibizumab. Conclusion: This registry represents one of the largest cohorts of European patients with CSC to date. Patient age and the proportion of women were higher than expected and bilateral active disease was lower than anticipated, highlighting that neither age nor gender should be overemphasized when diagnosing CSC. Therapeutic interventions are heterogeneous and include verteporfin photodynamic therapy, micropulse laser, and anti-VEGF injections in case of secondary CNV. }", issn = {0030-3755}, doi = {10.1159/000535930}, url = {https://doi.org/10.1159/000535930}, eprint = {https://karger.com/oph/article-pdf/doi/10.1159/000535930/4178133/000535930.pdf}, } |
Svenja
Sonntag,
Britta
Klein,
Ralf
Brinkmann,
Salvatore
Grisanti, and
Yoko
Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration, Translational Vision Science & Technology , vol. 13, pp. 24-24, 01 2024.
Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration, Translational Vision Science & Technology , vol. 13, pp. 24-24, 01 2024.
DOI: | 10.1167/tvst.13.1.24 |
Weblink: | https://doi.org/10.1167/tvst.13.1.24 |
Bibtex: | ![]() @article{10.1167/tvst.13.1.24, author = {Sonntag, Svenja Rebecca and Klein, Britta and Brinkmann, Ralf and Grisanti, Salvatore and Miura, Yoko}, title = "{Fluorescence Lifetime Imaging Ophthalmoscopy of Mouse Models of Age-related Macular Degeneration}", journal = {Translational Vision Science & Technology}, volume = {13}, number = {1}, pages = {24-24}, year = {2024}, month = {01}, abstract = "{ To investigate fluorescence lifetime of mouse models of age-related macular degeneration (AMD) by fluorescence lifetime imaging ophthalmoscopy (FLIO). Two AMD mouse models, apolipoprotein E knockout (ApoE−/−) mice and NF-E2-related factor-2 knockout (Nrf2−/−) mice, and their wild-type mice underwent monthly ophthalmic examinations including FLIO from 3 months of age. After euthanasia at the age of 6 or 11 months, blood plasma was collected to determine total antioxidant capacity and eyes were enucleated for Oil red O (ORO) lipid staining of chorioretinal tissue. In FLIO, the mean fluorescence lifetime (τm) of wild type shortened with age in both spectral channels. In short spectral channel, τm shortening was observed in both AMD models as well, but its rate was more pronounced in ApoE−/− mice and significantly different from the other strains as months of age progressed. In contrast, in long spectral channel, both model strains showed completely opposite trends, with τm becoming shorter in ApoE−/− and longer in Nrf2−/− mice than the others. Oil red O staining at Bruch's membrane was significantly stronger in ApoE−/− mice at 11 months than the other strains. Plasma total antioxidant capacity was highest in ApoE−/− mice at both 6 and 11 months. The two AMD mouse models exhibited largely different fundus fluorescence lifetime, which might be related to the different systemic metabolic state. FLIO might be able to indicate different metabolic states of eyes at risk for AMD. This animal study may provide new insights into the relationship between early AMD-associated metabolic changes and FLIO findings. }", issn = {2164-2591}, doi = {10.1167/tvst.13.1.24}, url = {https://doi.org/10.1167/tvst.13.1.24}, eprint = {https://arvojournals.org/arvo/content\_public/journal/tvst/938660/i2164-2591-13-1-24\_1706520239.75643.pdf}, } |
Paula
Enzian,
Nina
Kleineberg,
Elisabeth
Kirchert,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Light-Induced Liposomal Drug Delivery with an Amphiphilic Porphyrin and Its Chlorin and Bacteriochlorin Analogues, Molecular Pharmaceutics , pp. null, 01 2024.
Light-Induced Liposomal Drug Delivery with an Amphiphilic Porphyrin and Its Chlorin and Bacteriochlorin Analogues, Molecular Pharmaceutics , pp. null, 01 2024.
DOI: | 10.1021/acs.molpharmaceut.3c00749 |
Datei: | acs.molpharmaceut.3c00749 |
Bibtex: | ![]() @article{doi:10.1021/acs.molpharmaceut.3c00749, author = {Enzian, Paula and Kleineberg, Nina and Kirchert, Elisabeth and Schell, Christian and Rahmanzadeh, Ramtin}, title = {Light-Induced Liposomal Drug Delivery with an Amphiphilic Porphyrin and Its Chlorin and Bacteriochlorin Analogues}, journal = {Molecular Pharmaceutics}, volume = {0}, number = {0}, pages = {null}, year = {0}, doi = {10.1021/acs.molpharmaceut.3c00749}, note ={PMID: 38189667}, URL = { https://doi.org/10.1021/acs.molpharmaceut.3c00749 }, eprint = { https://doi.org/10.1021/acs.molpharmaceut.3c00749 } } |
Maron
Dolling,
Lara
Buhl,
Reginald
Birngruber,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Algorithm and software for field distortion correction in a commercial SD-OCT for corneal curvature assessment, Appl. Opt. , vol. 63, no. 10, pp. 2694--2703, 2024. Optica Publishing Group.
Algorithm and software for field distortion correction in a commercial SD-OCT for corneal curvature assessment, Appl. Opt. , vol. 63, no. 10, pp. 2694--2703, 2024. Optica Publishing Group.
DOI: | 10.1364/AO.505107 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{Dolling:24, author = {Maron Dolling and Lara Buhl and Reginald Birngruber and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt}, journal = {Appl. Opt.}, keywords = {Distortion; Imaging systems; Optical aberration; Optical components; Spectral domain optical coherence tomography; Systems design}, number = {10}, pages = {2694--2703}, publisher = {Optica Publishing Group}, title = {Algorithm and software for field distortion correction in a commercial SD-OCT for corneal curvature assessment}, volume = {63}, month = {Apr}, year = {2024}, url = {https://opg.optica.org/ao/abstract.cfm?URI=ao-63-10-2694}, doi = {10.1364/AO.505107}, abstract = {Accurate assessment of corneal curvatures using frequency domain optical coherence tomography (OCT) with galvanometer scanners remains challenging due to the well-known scan field distortion. This paper presents an algorithm and software for correcting the distortion using only two simple measurements in which a readily available standard sphere is positioned in different depths in front of the OCT scanner. This offers a highly accessible and easily reproducible method for the field distortion correction (FDC). The correction was validated by measuring different spherical phantoms and conducting corneal curvature measurements of ex vivo porcine corneas using a commercial spectral-domain OCT system and a clinically approved swept-source OCT as a reference instrument. Thus, the error in radius measurements of spherical phantoms was reduced by \>90\% and astigmatism by \>80\% using FDC. In explanted porcine eyes, the error in astigmatism measurements with the Telesto was reduced by 75\% for power and 70\% for angle. The best fitting sphere radius was determined up to a deviation of 0.4\% from the Anterion. This paper describes a correction algorithm for OCT immanent distortion that is applicable to any scanning OCT setup and enables precise corneal curvature measurements. The MATLAB software for the FDC is publicly available on GitHub.}, } |
Lei
Fu,
Jing
Wang,
Siqi
Wang,
Zhenxi
Zhang,
Alfred
Vogel,
Xiao-Xuan
Liang, and
Cuiping
Yao,
Secondary cavitation bubble dynamics during laser-induced bubble formation in a small container, Opt. Express , vol. 32, no. 6, pp. 9747--9766, 2024. Optica Publishing Group.
Secondary cavitation bubble dynamics during laser-induced bubble formation in a small container, Opt. Express , vol. 32, no. 6, pp. 9747--9766, 2024. Optica Publishing Group.
DOI: | 10.1364/OE.516264 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{Fu:24, author = {Lei Fu and Jing Wang and Siqi Wang and Zhenxi Zhang and Alfred Vogel and Xiao-xuan Liang and Cuiping Yao}, journal = {Opt. Express}, keywords = {Laser beams; Laser light; Laser materials; Laser surgery; Numerical simulation; Phase shift}, number = {6}, pages = {9747--9766}, publisher = {Optica Publishing Group}, title = {Secondary cavitation bubble dynamics during laser-induced bubble formation in a small container}, volume = {32}, month = {Mar}, year = {2024}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-32-6-9747}, doi = {10.1364/OE.516264}, abstract = {We investigated secondary cavitation bubble dynamics during laser-induced bubble formation in a small container with a partially confined free surface and elastic thin walls. We employed high-speed photography to record the dynamics of sub-mm-sized laser-induced bubbles and small secondary bubble clouds. Simultaneous light scattering and acoustic measurements were used to detect the oscillation times of laser-induced bubbles. We observed that the appearance of secondary bubbles coincides with a prolonged collapse phase and with re-oscillations of the laser-induced bubble. We observed an asymmetric distribution of secondary bubbles with a preference for the upstream side of the focus, an absence of secondary bubbles in the immediate vicinity of the laser focus, and a migration of laser-induced bubble toward secondary bubbles at large pulse energies. We found that secondary bubbles are created through heating of impurities to form initial nanobubble nuclei, which are further expanded by rarefaction waves. The rarefaction waves originate from the vibration of the elastic thin walls, which are excited either directly by laser-induced bubble or by bubble-excited liquid-mass oscillations. The oscillation period of thin walls and liquid-mass were Twall\&\#x2009;\&\#x003D;\&\#x2009;116 \&\#x00B5;s and Tlm \&\#x2248; 160 \&\#x00B5;s, respectively. While the amplitude of the wall vibrations increases monotonically with the size of laser-induced bubbles, the amplitude of liquid-mass oscillation undulates with increasing bubble size. This can be attributed to a phase shift between the laser-induced bubble oscillation and the liquid-mass oscillator. Mutual interactions between the laser-induced bubble and secondary bubbles reveal a fast-changing pressure gradient in the liquid. Our study provides a better understanding of laser-induced bubble dynamics in a partially confined environment, which is of practical importance for microfluidics and intraluminal laser surgery.}, } |
Andrey
Boyko,
Birgit
Lange,
Sebastian
Eckert,
Fedor
Mayorov, and
Ralf
Brinkmann,
Signal Enhancement of a Differential Photoacoustic Cell by Connecting the Microphones via Capillaries, Sensors , vol. 24, no. 7, 2024.
Signal Enhancement of a Differential Photoacoustic Cell by Connecting the Microphones via Capillaries, Sensors , vol. 24, no. 7, 2024.
DOI: | 10.3390/s24072105 |
Datei: | 2105 |
Bibtex: | ![]() @Article{s24072105, AUTHOR = {Boyko, Andrey and Lange, Birgit and Eckert, Sebastian and Mayorov, Fedor and Brinkmann, Ralf}, TITLE = {Signal Enhancement of a Differential Photoacoustic Cell by Connecting the Microphones via Capillaries}, JOURNAL = {Sensors}, VOLUME = {24}, YEAR = {2024}, NUMBER = {7}, ARTICLE-NUMBER = {2105}, URL = {https://www.mdpi.com/1424-8220/24/7/2105}, ISSN = {1424-8220}, ABSTRACT = {Differential photoacoustic spectroscopy (DPAS) cells are usually excited on the first longitudinal ring mode, with a microphone situated in the middle of each of the two resonator tubes. However, it is known from other photoacoustic spectroscopy cell designs that connecting the microphones via a capillary can lead to signal enhancement. By means of finite element method (FEM) simulations, we compared such a photoacoustic spectroscopy (PAS) cell with a capillary to a DPAS cell with a capillary attached to each of the two resonators and showed that the behavior of both systems is qualitatively the same: In both the PAS and the DPAS cell, in-phase and anti-phase oscillations of the coupled system (resonator–capillary) can be excited. In the DPAS cell, capillaries of suitable length also increase the pressure signal at the microphones according to the FEM simulations. For different capillary diameters (1.2 mm/1.7 mm/2.2 mm), the respective optimal capillary length (36–37.5 mm) and signal amplification was determined (94%, 70%, 53%). According to the results of these FEM simulations, a significant increase in sensitivity can, therefore, also be achieved in DPAS cells by expanding them with thin tubes leading to the microphones.}, DOI = {10.3390/s24072105} } |
Awanish Pratap
Singh,
Madita
Göb,
Martin
Ahrens,
Tim
Eixmann,
Berenice
Schulte,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Mark
Ellrichmann,
Robert
Huber, and
Maik
Rahlves,
Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization, Opt. Express , vol. 32, no. 4, pp. 5809--5825, 2024. Optica Publishing Group.
Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization, Opt. Express , vol. 32, no. 4, pp. 5809--5825, 2024. Optica Publishing Group.
DOI: | 10.1364/OE.514636 |
Bibtex: | ![]() @article{Singh:24, author = {Awanish Pratap Singh and Madita G\"{o}b and Martin Ahrens and Tim Eixmann and Berenice Schulte and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Mark Ellrichmann and Robert Huber and Maik Rahlves}, journal = {Opt. Express}, keywords = {Biomedical imaging; Endoscopic imaging; Imaging systems; Optical coherence tomography; Real time imaging; Vertical cavity surface emitting lasers}, number = {4}, pages = {5809--5825}, publisher = {Optica Publishing Group}, title = {Virtual Hall sensor triggered multi-MHz endoscopic OCT imaging for stable real-time visualization}, volume = {32}, month = {Feb}, year = {2024}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-32-4-5809}, doi = {10.1364/OE.514636}, abstract = {Circumferential scanning in endoscopic imaging is crucial across various disciplines, and optical coherence tomography (OCT) is often the preferred choice due to its high-speed, high-resolution, and micron-scale imaging capabilities. Moreover, real-time and high-speed 3D endoscopy is a pivotal technology for medical screening and precise surgical guidance, among other applications. However, challenges such as image jitter and non-uniform rotational distortion (NURD) are persistent obstacles that hinder real-time visualization during high-speed OCT procedures. To address this issue, we developed an innovative, low-cost endoscope that employs a brushless DC motor for scanning, and a sensorless technique for triggering and synchronizing OCT imaging with the scanning motor. This sensorless approach uses the motor\&\#x2019;s electrical feedback (back electromotive force, BEMF) as a virtual Hall sensor to initiate OCT image acquisition and synchronize it with a Fourier Domain Mode-Locked (FDML)-based Megahertz OCT system. Notably, the implementation of BEMF-triggered OCT has led to a substantial reduction in image jitter and NURD (\<4 mrad), thereby opening up a new window for real-time visualization capabilities. This approach suggests potential benefits across various applications, aiming to provide a more accurate, deployable, and cost-effective solution. Subsequent studies can explore the adaptability of this system to specific clinical scenarios and its performance under practical endoscopic conditions.}, } |
Clara
Pfäffle,
Leo
Puyo,
Hendrik
Spahr,
Dierck
Hillmann,
Yoko
Miura, and
Gereon
Hüttmann,
Unraveling the Functional Signals of Rods and Cones in the Human Retina: Separation and Analysis, Frontiers in Ophthalmology , vol. 4, 2024.
Unraveling the Functional Signals of Rods and Cones in the Human Retina: Separation and Analysis, Frontiers in Ophthalmology , vol. 4, 2024.
DOI: | 10.3389/fopht.2024.1340692 |
Datei: | fopht.2024.1340692 |
Bibtex: | ![]() @ARTICLE{10.3389/fopht.2024.1340692, AUTHOR={Pfäffle, Clara and Puyo, Léo and Spahr, Hendrik and Hillmann, Dierck and Miura, Yoko and Hüttmann, Gereon}, TITLE={Unraveling the Functional Signals of Rods and Cones in the Human Retina: Separation and Analysis}, JOURNAL={Frontiers in Ophthalmology}, VOLUME={4}, YEAR={2024}, URL={https://www.frontiersin.org/articles/10.3389/fopht.2024.1340692}, DOI={10.3389/fopht.2024.1340692}, ISSN={2674-0826} } |
Natalie
Thiemann,
Svenja Rebecca
Sonntag,
Marie
Kreikenbohm,
Giulia
Böhmerle,
Jessica
Stagge,
Salvatore
Grisanti,
Thomas
Martinetz, and
Yoko
Miura,
Artificial Intelligence in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Data Analysis—Toward Retinal Metabolic Diagnostics, Diagnostics , vol. 14, no. 4, 2024.
Artificial Intelligence in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Data Analysis—Toward Retinal Metabolic Diagnostics, Diagnostics , vol. 14, no. 4, 2024.
DOI: | 10.3390/diagnostics14040431 |
Datei: | 431 |
Bibtex: | ![]() @Article{diagnostics14040431, AUTHOR = {Thiemann, Natalie and Sonntag, Svenja Rebecca and Kreikenbohm, Marie and Böhmerle, Giulia and Stagge, Jessica and Grisanti, Salvatore and Martinetz, Thomas and Miura, Yoko}, TITLE = {Artificial Intelligence in Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Data Analysis—Toward Retinal Metabolic Diagnostics}, JOURNAL = {Diagnostics}, VOLUME = {14}, YEAR = {2024}, NUMBER = {4}, ARTICLE-NUMBER = {431}, URL = {https://www.mdpi.com/2075-4418/14/4/431}, ISSN = {2075-4418}, ABSTRACT = {The purpose of this study was to investigate the possibility of implementing an artificial intelligence (AI) approach for the analysis of fluorescence lifetime imaging ophthalmoscopy (FLIO) data even with small data. FLIO data, including the fluorescence intensity and mean fluorescence lifetime (τm) of two spectral channels, as well as OCT-A data from 26 non-smokers and 28 smokers without systemic and ocular diseases were used. The analysis was performed with support vector machines (SVMs), a well-known AI method for small datasets, and compared with the results of convolutional neural networks (CNNs) and autoencoder networks. The SVM was the only tested AI method, which was able to distinguish τm between non-smokers and heavy smokers. The accuracy was about 80%. OCT-A data did not show significant differences. The feasibility and usefulness of the AI in analyzing FLIO and OCT-A data without any apparent retinal diseases were demonstrated. Although further studies with larger datasets are necessary to validate the results, the results greatly suggest that AI could be useful in analyzing FLIO-data even from healthy subjects without retinal disease and even with small datasets. AI-assisted FLIO is expected to greatly advance early retinal diagnosis.}, DOI = {10.3390/diagnostics14040431} } |
Sazgar
Burhan,
Nicolas
Detrez,
Katharina
Rewerts,
Paul
Strenge,
Steffen
Buschschlüter,
Jessica
Kren,
Christian
Hagel,
Matteo Mario
Bonsanto,
Ralf
Brinkmann, and
Robert
Huber,
Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue, Biomed. Opt. Express , vol. 15, no. 2, pp. 1038--1058, 2024. Optica Publishing Group.
Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue, Biomed. Opt. Express , vol. 15, no. 2, pp. 1038--1058, 2024. Optica Publishing Group.
DOI: | 10.1364/BOE.510020 |
Bibtex: | ![]() @article{Burhan:24, author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Paul Strenge and Steffen Buschschl\"{u}ter and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber}, journal = {Biomed. Opt. Express}, keywords = {High speed imaging; Imaging systems; In vivo imaging; Magnetic resonance imaging; Phase noise; Phase shift}, number = {2}, pages = {1038--1058}, publisher = {Optica Publishing Group}, title = {Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue}, volume = {15}, month = {Feb}, year = {2024}, url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-15-2-1038}, doi = {10.1364/BOE.510020}, abstract = {During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2\&\#x2005;MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2\&\#x03C0; wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm\&\#x0027;s reliability. The tissue samples were subjected to a 200\&\#x2005;ms short air pulse. A correlation with histological findings confirmed the algorithm\&\#x0027;s dependability.}, } |
Patrick
Kuppler,
Paul
Strenge,
Birgit
Lange,
Sonja
Spahr-Hess,
Wolfgang
Draxinger,
Christian
Hagel,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Robert
Huber,
Volker
Tronnier, and
Matteo Mario
Bonsanto,
Microscope-integrated optical coherence tomography for in vivo human brain tumor detection with artificial intelligence, Journal of Neurosurgery , pp. 1 - 9, 2024. American Association of Neurological Surgeons.
Microscope-integrated optical coherence tomography for in vivo human brain tumor detection with artificial intelligence, Journal of Neurosurgery , pp. 1 - 9, 2024. American Association of Neurological Surgeons.
DOI: | 10.3171/2024.1.JNS231511 |
Bibtex: | ![]() @article { Microscopeintegratedopticalcoherencetomographyforinvivohumanbraintumordetectionwithartificialintelligence, author = "Patrick Kuppler and Paul Strenge and Birgit Lange and Sonja Spahr-Hess and Wolfgang Draxinger and Christian Hagel and Dirk Theisen-Kunde and Ralf Brinkmann and Robert Huber and Volker Tronnier and Matteo Mario Bonsanto", title = "Microscope-integrated optical coherence tomography for in vivo human brain tumor detection with artificial intelligence", journal = "Journal of Neurosurgery", year = "2024", publisher = "American Association of Neurological Surgeons", doi = "10.3171/2024.1.JNS231511", pages= "1 - 9", url = "https://thejns.org/view/journals/j-neurosurg/aop/article-10.3171-2024.1.JNS231511/article-10.3171-2024.1.JNS231511.xml" } |
Gereon Hüttmann,
Mathematical model for separating signal and noise in dynamic optical coherence tomography (dOCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC1283029.
Mathematical model for separating signal and noise in dynamic optical coherence tomography (dOCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC1283029.
DOI: | 10.1117/12.3005716 |
Weblink: | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12830/PC1283029/Mathematical-model-for-separating-signal-and-noise-in-dynamic-optical/10.1117/12.3005716.short |
Bibtex: | ![]() @inproceedings{10.1117/12.3005716, author = {Gereon Hüttmann}, title = {Mathematical model for separating signal and noise in dynamic optical coherence tomography (dOCT)}, volume = {PC12830}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {PC1283029}, abstract = {Dynamic optical coherence tomography (dOCT) uses signal fluctuation for contrasting different cellular and acellular components in living biological tissue. The autocorrelation or Fourier transform of time series of OCT measurements are converted to a color contrast. However, a quantitative analysis is still challenging. Here we investigate theoretically, how noise of the OCT measurement influences the fluctuation spectra. Probability functions are derived for the different components in the spectra and validated by numerical simulation. With an appropriate calibration of the OCT device a separation of OCT noise and a quantification the dynamic OCT should be feasible.}, keywords = {Optical coherence tomography (OCT), Dynamic optical coherence tomography (OCT), Signal to noise, Speckle statistics, Quantification}, year = {2024}, doi = {10.1117/12.3005716}, URL = {https://doi.org/10.1117/12.3005716} } |
Noah
Heldt,
Cornelia
Holzhausen,
Martin
Ahrens,
Mario
Pieper,
Peter
König, and
Gereon
Hüttmann,
Improved image quality in dynamic OCT imaging by reduced imaging time and machine learning based data evaluation, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC128302A.
Improved image quality in dynamic OCT imaging by reduced imaging time and machine learning based data evaluation, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2024. pp. PC128302A.
DOI: | 10.1117/12.3005413 |
Weblink: | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/PC12830/PC128302A/Improved-image-quality-in-dynamic-OCT-imaging-by-reduced-imaging/10.1117/12.3005413.full |
Bibtex: | ![]() @inproceedings{10.1117/12.3005413, author = {Noah Heldt and Cornelia Holzhausen and Martin Ahrens and Mario Pieper and Peter K{\"o}nig and Gereon H{\"u}ttmann}, title = {{Improved image quality in dynamic OCT imaging by reduced imaging time and machine learning based data evaluation}}, volume = {PC12830}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVIII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {PC128302A}, abstract = {Dynamic Optical Coherence Tomography combines high resolution tomographic imagery with a cell specific contrast by Fourier analysis. However, the conversion from frequency space into RGB images by binning requires a priori knowledge and artifacts due to global movements provide another obstacle for in vivo application. We could show that an automated binning based on the Neural Gas algorithm can yield the highest spectral contrast without a priori knowledge and that motion artifacts can be reduced with shorter sequence lengths. Imaging murine airways, we observed that even just 6 frames are enough to generate dOCT images without losing important image information.}, keywords = {Dynamic OCT, Optical Coherence Tomography, Airways, Artificial Intelligence}, year = {2024}, doi = {10.1117/12.3005413}, URL = {https://doi.org/10.1117/12.3005413} } |
Masayo
Kajita,
Mitsuhiro
Nishida,
Satoshi
Yokota,
Sunao
Sugita,
Toshika
Semba,
Satoshi
Shirae,
Naoko
Hayashi,
Atsuta
Ozaki,
Yoko
Miura,
Akiko
Maeda,
Yoshinori
Mitamura,
Masayo
Takahashi, and
Michiko
Mandai,
Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage, Scientific Reports , vol. 14, no. 1, pp. 10044, 2024.
Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage, Scientific Reports , vol. 14, no. 1, pp. 10044, 2024.
DOI: | 10.1038/s41598-024-60895-w |
Datei: | s41598-024-60895-w |
Bibtex: | ![]() @article{RN5490, author = {Kajita, Keisuke;Nishida, Mitsuhiro;Kurimoto, Yasuo;Yokota, Satoshi;Sugita, Sunao;Semba, Toshika;Shirae, Satoshi;Hayashi, Naoko;Ozaki, Atsuta;Miura, Yoko;Maeda, Akiko;Mitamura, Yoshinori;Takahashi, Masayo and Mandai, Michiko}, title = {Graft cell expansion from hiPSC-RPE strip after transplantation in primate eyes with or without RPE damage}, journal = {Scientific Reports}, volume = {14}, number = {1}, pages = {10044}, ISSN = {2045-2322}, DOI = {10.1038/s41598-024-60895-w}, url = {https://doi.org/10.1038/s41598-024-60895-w}, year = {2024}, type = {Journal Article} } |
Svenja
Sonntag,
Maximilian
Hamann,
Eric
Seifert,
Salvatore
Grisanti,
Ralf
Brinkmann, and
Yoko
Miura,
Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium, Graefe's Archive for Clinical and Experimental Ophthalmology , 2024.
Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium, Graefe's Archive for Clinical and Experimental Ophthalmology , 2024.
DOI: | 10.1007/s00417-024-06449-2 |
Datei: | s00417-024-06449-2 |
Bibtex: | ![]() @article{RN5480, author = {Sonntag, Svenja Rebecca;Hamann, Maximilian;Seifert, Eric;Grisanti, Salvatore;Brinkmann, Ralf and Miura, Yoko}, title = {Detection sensitivity of fluorescence lifetime imaging ophthalmoscopy for laser-induced selective damage of retinal pigment epithelium}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, ISSN = {1435-702X}, DOI = {10.1007/s00417-024-06449-2}, url = {https://doi.org/10.1007/s00417-024-06449-2}, year = {2024}, type = {Journal Article} } |
Yoko Miura,
Organkultur des retinalen Pigmentepithels, in Das Retinale Pigmentepithel -- Physiologie und Pathologie , Klettner, Alexa Karina and Dithmar, Stefan, Eds. Cham: Springer International Publishing, 2024, pp. 337--356.
Organkultur des retinalen Pigmentepithels, in Das Retinale Pigmentepithel -- Physiologie und Pathologie , Klettner, Alexa Karina and Dithmar, Stefan, Eds. Cham: Springer International Publishing, 2024, pp. 337--356.
DOI: | 10.1007/978-3-031-35055-9_18 |
ISBN: | 978-3-031-35055-9 |
Datei: | 978-3-031-35055-9_18 |
Bibtex: | ![]() @Inbook{Miura2024, author="Miura, Yoko", editor="Klettner, Alexa Karina and Dithmar, Stefan", title="Organkultur des retinalen Pigmentepithels", bookTitle="Das Retinale Pigmentepithel -- Physiologie und Pathologie", year="2024", publisher="Springer International Publishing", address="Cham", pages="337--356", abstract="Retinales Pigmentepithel (RPE)-Organkultur wird hier als die Erhaltung von Gewebeexplantaten, einschlie{\ss}lich des RPE-Monolayers, in einem lebenden Zustand {\"u}ber einen bestimmten Zeitraum definiert, mit dem Zweck, ein lebendes RPE zu untersuchen. Es gibt haupts{\"a}chlich zwei verschiedene Arten von RPE-Organkulturen; RPE-Choroid-Organkultur und RPE-Choroid-Sklera-Organkultur. Als Kultursystem gibt es statische und Perfusionskultursysteme. Die Kokultivierung mit der neuronalen Retina ist auch eine Option. Da Studien mit RPE-Organkultur eine vermittelnde Rolle als Br{\"u}cke zwischen in vitro und in vivo Studien einnehmen, k{\"o}nnte das richtige Wissen {\"u}ber die RPE-Organkultur f{\"u}r die Wahl des geeigneten experimentellen Modells f{\"u}r jede Studie recht hilfreich sein. In diesem Kapitel werden verschiedene Typen und Systeme von RPE-Organkulturen vorgestellt, zusammen mit ihren morphologischen und funktionellen Eigenschaften sowie Vor- und Nachteilen. Schlie{\ss}lich werden ihre m{\"o}glichen Anwendungen in der ophthalmologischen Forschung aus fr{\"u}heren und laufenden Studien vorgestellt.", isbn="978-3-031-35055-9", doi="10.1007/978-3-031-35055-9_18", url="https://doi.org/10.1007/978-3-031-35055-9_18" } |
2023
Marie
Klufts,
A. Martínez
Jiménez,
Simon
Lotz,
Muhammad Asim
Bashir,
Tom
Pfeiffer,
Alexander
Mlynek,
Wolfgang
Wieser,
Alexander
Chamorovskiy,
Adrian
Bradu,
Adrian
Podoleanu, and
Robert
Huber,
828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser, Biomed. Opt. Express , vol. 14, no. 12, pp. 6493-6508, Nov. 2023. Optica Publishing Group.
828 kHz retinal imaging with an 840 nm Fourier domain mode locked laser, Biomed. Opt. Express , vol. 14, no. 12, pp. 6493-6508, Nov. 2023. Optica Publishing Group.
DOI: | 10.1364/BOE.504302 |
Bibtex: | ![]() @article{Klufts:23, author = {Marie Klufts and Alejandro Martinez Jimenez and Simon Lotz and Muhammad Asim Bashir and Tom Pfeiffer and Alexander Mlynek and Wolfgang Wieser and Alexander Chamorovskiy and Adrian Bradu and Adrian Podoleanu and Robert Huber}, journal = {Biomed. Opt. Express}, keywords = {Analog to digital converters; Laser beams; Laser imaging; Laser modes; Point spread function; Vertical cavity surface emitting lasers}, number = {12}, pages = {6493--6508}, publisher = {Optica Publishing Group}, title = {828 kHz retinal imaging with an 840\&\#x2005;nm Fourier domain mode locked laser}, volume = {14}, month = {Dec}, year = {2023}, url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-14-12-6493}, abstract = {This paper presents a Fourier domain mode locked (FDML) laser centered around 840 nm. It features a bidirectional sweep repetition rate of 828 kHz and a spectral bandwidth of 40 nm. An axial resolution of ∼9.9 µm in water and a 1.4 cm sensitivity roll-off are achieved. Utilizing a complex master-slave (CMS) recalibration method and due to a sufficiently high sensitivity of 84.6 dB, retinal layers of the human eye in-vivo can be resolved during optical coherence tomography (OCT) examination. The developed FDML laser enables acquisition rates of 3D-volumes with a size of 200 × 100 × 256 voxels in under 100 milliseconds. Detailed information on the FDML implementation, its challenging design tasks, and OCT images obtained with the laser are presented in this paper.}, } |
Sazgar
Burhan,
Nicolas
Detrez,
Madita
Göb,
Matteo Mario
Bonsanto,
Ralf
Brinkmann, and
Robert
Huber,
Advanced FFT-based contrast approach for MHz optical coherence elastography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 1263215.
Advanced FFT-based contrast approach for MHz optical coherence elastography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 1263215.
DOI: | 10.1117/12.2670957 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670957, author = {Sazgar Burhan and Nicolas Detrez and Madita G{\"o}b and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber}, title = {{Advanced FFT-based contrast approach for MHz optical coherence elastography}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1263215}, abstract = {Optical coherence elastography represents mechanical characteristics of biological tissue in so-called mechanical contrast maps. In addition to the standard intensity image, the contrast map illustrates numerous mechanical tissue features that would otherwise be undetectable. This is of great interest as abnormal physiological changes influence the mechanical behavior of the tissue. We demonstrate an advanced mechanical contrast approach based on the phase signal of our 3.2 MHz optical coherence tomography system. The robustness and performance of this contrast approach is evaluated and discussed based on preliminary results. }, keywords = {Optical Coherence Tomography, OCT, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, OCE, Phase-sensitive OCT, Biomechanics}, year = {2023}, doi = {10.1117/12.2670957}, URL = {https://doi.org/10.1117/12.2670957} } |
Wolfgang
Draxinger,
Dirk
Theisen-Kunde,
Lion
Schuetz,
Nicolas
Detrez,
Paul
Strenge,
Maximilian
Rixius,
Veit
Danicke,
Wolfgang
Wieser,
Jessica
Kren,
Patrick
Kuppler,
Sonja
Spar-Hess,
Matteo M.
Bonsanto,
Ralf
Brinkmann, and
Robert
Huber,
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 082023. pp. 126270W.
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 082023. pp. 126270W.
DOI: | 10.1117/12.2670953 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670953, author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber}, title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126270W}, abstract = {Microscope integrated realtime 4D MHz-OCT operating at high scanning densities are capable of capturing additional visual contrast resolving depth and tissue. Even within a plain C-scan en-face projection structures are recognizable, that are not visible in a white light camera image. With advanced post processing methods, such as absorbtion coefficient mapping, and morphological classifiers more information is extraced. Presentation to the user in an intuitive way poses practical challenges that go beyond the implementation of a mere overlay display. We present our microscope integrated high speed 4D OCT imaging system, its clinical study use for in-vivo brain tissue imaging, and user feedback on the presentation methods we developed.}, keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics}, year = {2023}, doi = {10.1117/12.2670953}, URL = {https://doi.org/10.1117/12.2670953} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christian
Hagel,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321P.
Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321P.
DOI: | 10.1117/12.2670907 |
Datei: | 12.2670907 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670907, author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann}, title = {{Demarcation of brain and tumor tissue with optical coherence tomography using prior neural networks}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126321P}, keywords = {Brain Tumor, OCT, Optical Coherence Tomography, Prior Network, Glioblastoma Multiforme, Neural Network, Classification}, year = {2023}, doi = {10.1117/12.2670907}, URL = {https://doi.org/10.1117/12.2670907} } |
Madita
Göb,
Simon
Lotz,
Linh
Ha-Wissel,
Sazgar
Burhan,
Sven
Böttger,
Floris
Ernst,
Jennifer
Hundt, and
Robert
Huber,
Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321N.
Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 082023. pp. 126321N.
DOI: | 10.1117/12.2670950 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670950, author = {Madita G{\"o}b and Simon Lotz and Linh Ha-Wissel and Sazgar Burhan and Sven B{\"o}ttger and Floris Ernst and Jennifer Hundt and Robert Huber}, title = {{Advances in large area robotically assisted OCT (LARA-OCT): towards drive-by continuous motion imaging}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126321N}, abstract = {Optical coherence tomography is a powerful imaging technique to visualize and localize depth-dependent tissue structure to differentiate between healthy and pathological conditions. However, conventional OCT systems are only capable of detecting small areas. To overcome this limitation, we have developed a large area robotically assisted OCT (LARA-OCT) system for automatic acquisition of large OCT images. Using mosaic pattern acquisition and subsequent stitching, we previously demonstrated initial in vivo OCT skin images beyond 10 cm². To improve acquisition speed and reduce dead times, we here demonstrate and analyze LARA-OCT with a new drive-by continuous motion imaging protocol.}, keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, Robotically Assisted Imaging Systems, Three-dimensional image acquisition, Large Area Scanning, Skin Imaging, OCT, FDML}, year = {2023}, doi = {10.1117/12.2670950}, URL = {https://doi.org/10.1117/12.2670950} } |
Simon
Lotz,
Madita
Göb,
Wolfgang
Draxinger,
Anneli
Dick, and
Robert
Huber,
13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI: | 10.1109/CLEO/Europe-EQEC57999.2023.10231419 |
Bibtex: | ![]() @INPROCEEDINGS{10231419, author={Lotz, Simon and Göb, Madita and Draxinger, Wolfgang and Dick, Anneli and Huber, Robert}, booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={13.4 MHz FDML Laser for Intra-Surgical Optical Coherence Tomography}, year={2023}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEO/Europe-EQEC57999.2023.10231419}} |
Philipp
Lamminger,
Hubertus
Hakert,
Simon
Lotz,
Jan Philip
Kolb,
Tonio
Kutscher,
Sebastian
Karpf, and
Robert
Huber,
Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI: | 10.1109/CLEO/Europe-EQEC57999.2023.10232141 |
Bibtex: | ![]() @INPROCEEDINGS{10232141, author={Lamminger, Philipp and Hakert, Hubertus and Lotz, Simon and Kolb, Jan Philip and Kutscher, Tonio and Karpf, Sebastian and Huber, Robert}, booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Four-Wave Mixing Fast Wavelength Sweeping FDML Laser with kW Peak Power at 900 nm and 1300 nm}, year={2023}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEO/Europe-EQEC57999.2023.10232141}} |
Marie
Klufts,
Simon
Lotz,
Muhammad Asim
Bashir,
Tom
Pfeiffer,
Alexander
Mlynek,
Wolfgang
Wieser,
Alexander
Chamorovskiy,
Vladimir
Shidlovski,
Adrian
Podoleanu, and
Robert
Huber,
Dual Amplification 850 nm FDML Laser, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
Dual Amplification 850 nm FDML Laser, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI: | 10.1109/CLEO/Europe-EQEC57999.2023.10232019 |
Bibtex: | ![]() @INPROCEEDINGS{10232019, author={Klufts, M. and Lotz, S. and Bashir, M. A. and Pfeiffer, T. and Mlynek, A. and Wieser, W. and Chamorovskiy, A. and Shidlovski, V. and Podoleanu, A. and Huber, R.}, booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Dual Amplification 850 nm FDML Laser}, year={2023}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEO/Europe-EQEC57999.2023.10232019}} |
Paula
Enzian, and
Ramtin
Rahmanzadeh,
Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer, Pharmaceutics , vol. 15, no. 8, 07 2023.
Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer, Pharmaceutics , vol. 15, no. 8, 07 2023.
DOI: | 10.3390/pharmaceutics15082040 |
Datei: | 2040 |
Bibtex: | ![]() @Article{pharmaceutics15082040, AUTHOR = {Enzian, Paula and Rahmanzadeh, Ramtin}, TITLE = {Photochemical Internalization with Fimaporfin: Enhanced Bleomycin Treatment for Head and Neck Cancer}, JOURNAL = {Pharmaceutics}, VOLUME = {15}, YEAR = {2023}, NUMBER = {8}, ARTICLE-NUMBER = {2040}, URL = {https://www.mdpi.com/1999-4923/15/8/2040}, ISSN = {1999-4923}, ABSTRACT = {Head and neck squamous cell carcinoma (HNSCC) still represents the world’s sixth most common tumor entity, with increasing incidence. The reachability of light makes HNSCC suitable for light-based therapies such as Photochemical Internalization (PCI). The drug Bleomycin is cytotoxic and used as an anti-tumor medication. Since Bleomycin is endocytosed as a relatively large molecule, part of it is degraded in lysosomes before reaching its intracellular target. The goal of our study was to improve the intracellular availability of Bleomycin with PCI. We investigate the intracellular delivery of Bleomycin after PCI with the photosensitizer Fimaporfin. A systematic variation of Bleomycin and Fimaporfin concentrations and light irradiation led to the pronounced cell death of HNSCC cells. After optimization, the same level of tumor cell death of 75% was reached with a 20-fold lower Bleomycin concentration. This would allow treatment of HNSCC with high local tumor cell death and reduce the side effects of Bleomycin, e.g., lung fibrosis, at the same time. This demonstrates the increased efficacy of the anti-tumor medication Bleomycin in combination with PCI.}, DOI = {10.3390/pharmaceutics15082040} } |
Svenja
Sonntag,
Marie
Kreikenbohm,
Giulia
Böhmerle,
Jessica
Stagge,
Salvatore
Grisanti, and
Yoko
Miura,
Impact of cigarette smoking on fluorescence lifetime of ocular fundus, Scientific Reports , vol. 13, no. 1, pp. 11484, 07 2023.
Impact of cigarette smoking on fluorescence lifetime of ocular fundus, Scientific Reports , vol. 13, no. 1, pp. 11484, 07 2023.
DOI: | 10.1038/s41598-023-37484-4 |
Datei: | s41598-023-37484-4 |
Bibtex: | ![]() @article{RN5446, author = {Sonntag, Svenja Rebecca;Kreikenbohm, Marie;Böhmerle, Giulia;Stagge, Jessica;Grisanti, Salvatore and Miura, Yoko}, title = {Impact of cigarette smoking on fluorescence lifetime of ocular fundus}, journal = {Scientific Reports}, volume = {13}, number = {1}, pages = {11484}, ISSN = {2045-2322}, DOI = {10.1038/s41598-023-37484-4}, url = {https://doi.org/10.1038/s41598-023-37484-4}, year = {2023}, type = {Journal Article} } |
Noah
Heldt,
Cornelia
Holzhausen,
Martin
Ahrens,
Mario
Pieper,
Peter
König, and
Gereon
Hüttmann,
Improved image quality in dynamic OCT imaging of airway and lung tissue by reduced imaging time and machine learning based data evaluation, in Abstract Book 11th DZL Annual Meeting , 11th DZL Annual Meeting, Fürstenfeldbruck, 14–16 June 2023, Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 072023. pp. 357.
Improved image quality in dynamic OCT imaging of airway and lung tissue by reduced imaging time and machine learning based data evaluation, in Abstract Book 11th DZL Annual Meeting , 11th DZL Annual Meeting, Fürstenfeldbruck, 14–16 June 2023, Deutsches Zentrum für Lungenforschung e. V Geschäftsstelle Aulweg 130 35392 Gießen: Deutsches Zentrum für Lungenforschung e. V, 072023. pp. 357.
Weblink: | https://dzl.de/wp-content/uploads/2023/06/Abstract-Book_2023-2.pdf |
Datei: | Dateilink |
Muhammad Asim
Bashir,
Simon
Lotz,
Marie
Klufts,
Christian
Jirauschek, and
Robert
Huber,
1190 nm FDML laser: Challenges and Strategies, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
1190 nm FDML laser: Challenges and Strategies, in 2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 072023. pp. 1.
DOI: | 10.1109/CLEO/Europe-EQEC57999.2023.10232661 |
Bibtex: | ![]() @INPROCEEDINGS{10232661, author={Bashir, M. A. and Lotz, S. and Kluftsa, M. and Jirauschek, C. and Huberab, R.}, booktitle={2023 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={1190 nm FDML laser: Challenges and Strategies}, year={2023}, volume={}, number={}, pages={1-1}, doi={10.1109/CLEO/Europe-EQEC57999.2023.10232661}} |
Philipp
Lamminger,
Hubertus
Hakert,
Simon
Lotz,
Jan Philip
Kolb,
Tonio
Kutscher,
Sebastian
Karpf, and
Robert
Huber,
Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm, Opt. Lett. , vol. 48, no. 14, pp. 3713-3716, 07 2023. Optica Publishing Group.
Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm, Opt. Lett. , vol. 48, no. 14, pp. 3713-3716, 07 2023. Optica Publishing Group.
DOI: | 10.1364/OL.488181 |
Bibtex: | ![]() @article{Lamminger:23, author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber}, journal = {Opt. Lett.}, keywords = {Green fluorescent protein; Laser beam combining; Laser crystals; Laser imaging; Optical amplifiers; Photonic crystal lasers}, number = {14}, pages = {3713--3716}, publisher = {Optica Publishing Group}, title = {Four-wave mixing seeded by a rapid wavelength-sweeping FDML laser for nonlinear imaging at 900 nm and 1300 nm}, volume = {48}, month = {Jul}, year = {2023}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-14-3713}, doi = {10.1364/OL.488181}, abstract = {Four-wave mixing (FWM) enables the generation and amplification of light in spectral regions where suitable fiber gain media are unavailable. The 1300 nm and 900 nm regions are of especially high interest for time-encoded (TICO) stimulated Raman scattering microscopy and spectro-temporal laser imaging by diffracted excitation (SLIDE) two-photon microscopy. We present a new, to the best of our knowledge, FWM setup where we shift the power of a home-built fully fiber-based master oscillator power amplifier (MOPA) at 1064 nm to the 1300-nm region of a rapidly wavelength-sweeping Fourier domain mode-locked (FDML) laser in a photonic crystal fiber (PCF) creating pulses in the 900-nm region. The resulting 900-nm light can be wavelength swept over 54 nm and has up to 2.5 kW (0.2 {\textmu}J) peak power and a narrow instantaneous spectral linewidth of 70 pm. The arbitrary pulse patterns of the MOPA and the fast wavelength tuning of the FDML laser (419 kHz) allow it to rapidly tune the FWM light enabling new and faster TICO-Raman microscopy, SLIDE imaging, and other applications.}, } |
Anke
Leichtle,
Zuzana
Penxova,
Thorge
Kempin,
David
Leffers,
Martin
Ahrens,
Peter
König,
Ralf
Brinkmann,
Gereon
Hüttmann,
Karl-Ludwig
Bruchhage, and
Hinnerk
Schulz-Hildebrandt,
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media, Photonics , vol. 10, no. 6, 06 2023.
Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media, Photonics , vol. 10, no. 6, 06 2023.
DOI: | 10.3390/photonics10060685 |
Datei: | 685 |
Bibtex: | ![]() @Article{photonics10060685, AUTHOR = {Leichtle, Anke and Penxova, Zuzana and Kempin, Thorge and Leffers, David and Ahrens, Martin and König, Peter and Brinkmann, Ralf and Hüttmann, Gereon and Bruchhage, Karl-Ludwig and Schulz-Hildebrandt, Hinnerk}, TITLE = {Dynamic Microscopic Optical Coherence Tomography as a New Diagnostic Tool for Otitis Media}, JOURNAL = {Photonics}, VOLUME = {10}, YEAR = {2023}, NUMBER = {6}, ARTICLE-NUMBER = {685}, URL = {https://www.mdpi.com/2304-6732/10/6/685}, ISSN = {2304-6732}, ABSTRACT = {Hypothesis: Otitis media (OM) can be successfully visualized and diagnosed by dynamic microscopic optical coherence tomography (dmOCT). Background: OM is one of the most common infectious diseases and, according to the WHO, one of the leading health problems with high mortality in developing countries. Despite intensive research, the only definitive treatment of therapy-refractory OM for decades has been the surgical removal of inflamed tissue. Thereby, the intra-operative diagnosis is limited to the surgeon’s visual impression. Supportive imaging modalities have been little explored and have not found their way into clinical application. Finding imaging techniques capable of identifying inflamed tissue intraoperatively, therefore, is of significant clinical relevance. Methods: This work investigated a modified version of optical coherence tomography with a microscopic resolution (mOCT) regarding its ability to differentiate between healthy and inflamed tissue. Despite its high resolution, the differentiation of single cells with mOCT is often impossible. A new form of mOCT termed dynamic mOCT (dmOCT) achieves cellular contrast using micro-movements within cells based on their metabolism. It was used in this study to establish correlative measurements with histology. Results: Using dmOCT, images with microscopic resolution were acquired on ex vivo tissue samples of chronic otitis media and cholesteatoma. Imaging with dmOCT allowed the visualization of specific and characteristic cellular and subcellular structures in the cross-sectional images, which can be identified only to a limited extent in native mOCT. Conclusion: We demonstrated for the first time a new marker-free visualization in otitis media based on intracellular motion using dmOCT.}, DOI = {10.3390/photonics10060685} } |
Michael
Schmalz,
Xiao-Xuan
Liang,
Ines
Wieser,
Caroline
Gruschel,
Lukas
Muskalla,
Martin Thomas
Stöckl,
Roland
Nitschke,
Norbert
Linz,
Alfred
Leitenstorfer,
Alfred
Vogel, and
Elisa
Ferrando-May,
Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling, Proceedings of the National Academy of Sciences , vol. 120, no. 25, pp. e2220132120, 06 2023.
Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling, Proceedings of the National Academy of Sciences , vol. 120, no. 25, pp. e2220132120, 06 2023.
DOI: | 10.1073/pnas.2220132120 |
Datei: | pnas.2220132120 |
Bibtex: | ![]() @article{ doi:10.1073/pnas.2220132120, author = {Michael Schmalz and Xiao-Xuan Liang and Ines Wieser and Caroline Gruschel and Lukas Muskalla and Martin Thomas Stöckl and Roland Nitschke and Norbert Linz and Alfred Leitenstorfer and Alfred Vogel and Elisa Ferrando-May }, title = {Dissection of DNA damage and repair pathways in live cells by femtosecond laser microirradiation and free-electron modeling}, journal = {Proceedings of the National Academy of Sciences}, volume = {120}, number = {25}, pages = {e2220132120}, year = {2023}, doi = {10.1073/pnas.2220132120}, URL = {https://www.pnas.org/doi/abs/10.1073/pnas.2220132120}, eprint = {https://www.pnas.org/doi/pdf/10.1073/pnas.2220132120}, abstract = {Understanding and predicting the outcome of the interaction of light with DNA has a significant impact on the study of DNA repair and radiotherapy. We report on a combination of femtosecond pulsed laser microirradiation at different wavelengths, quantitative imaging, and numerical modeling that yields a comprehensive picture of photon-mediated and free-electron-mediated DNA damage pathways in live cells. Laser irradiation was performed under highly standardized conditions at four wavelengths between 515 nm and 1,030 nm, enabling to study two-photon photochemical and free-electron-mediated DNA damage in situ. We quantitatively assessed cyclobutane pyrimidine dimer (CPD) and γH2AX-specific immunofluorescence signals to calibrate the damage threshold dose at these wavelengths and performed a comparative analysis of the recruitment of DNA repair factors xeroderma pigmentosum complementation group C (XPC) and Nijmegen breakage syndrome 1 (Nbs1). Our results show that two-photon-induced photochemical CPD generation dominates at 515 nm, while electron-mediated damage dominates at wavelengths ≥620 nm. The recruitment analysis revealed a cross talk between nucleotide excision and homologous recombination DNA repair pathways at 515 nm. Numerical simulations predicted electron densities and electron energy spectra, which govern the yield functions of a variety of direct electron-mediated DNA damage pathways and of indirect damage by •OH radicals resulting from laser and electron interactions with water. Combining these data with information on free electron–DNA interactions gained in artificial systems, we provide a conceptual framework for the interpretation of the wavelength dependence of laser-induced DNA damage that may guide the selection of irradiation parameters in studies and applications that require the selective induction of DNA lesions.}} |
Alexander
Altmann,
Michel
Eden,
Gereon
Hüttmann,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Porphyrin-based sensor films for monitoring food spoilage, Food Packaging and Shelf Life , vol. 38, pp. 101105, 06 2023.
Porphyrin-based sensor films for monitoring food spoilage, Food Packaging and Shelf Life , vol. 38, pp. 101105, 06 2023.
DOI: | https://doi.org/10.1016/j.fpsl.2023.101105 |
Datei: | S2214289423000820 |
Bibtex: | ![]() @article{ALTMANN2023101105, title = {Porphyrin-based sensor films for monitoring food spoilage}, journal = {Food Packaging and Shelf Life}, volume = {38}, pages = {101105}, year = {2023}, issn = {2214-2894}, doi = {https://doi.org/10.1016/j.fpsl.2023.101105}, url = {https://www.sciencedirect.com/science/article/pii/S2214289423000820}, author = {Alexander Altmann and Michel Eden and Gereon Hüttmann and Christian Schell and Ramtin Rahmanzadeh}, keywords = {Biogenic amines, Sensors, Fish freshness, Food safety, Porphyrin, Smart packaging}, abstract = {To increase food safety and to minimize food waste, it is interesting for the food industry and consumers to be able to determine food spoilage continuously and non-destructively. When food of animal origin is degraded, amines are released as protein breakdown products, which could be used to monitor the freshness of meat and fish. In this work, we introduce a porphyrin-based sensor foil aimed at the detection of biogenic amines. The sensor-porphyrin is formulated on mesoporous silica. Reactivity towards moderate humidity was eliminated by dispersion of the functionalized silica in polyethylene (PE), followed by thermal extrusion resulting in PE foils. After exposure to amines, the sensor foil changes its color irreversibly from green to red. The color change is accompanied by a pronounced shift of the fluorescence spectrum, which was used as a sensitive method to detect the degradation of fish products in model experiments. Titanium dioxide particles in the foil increased the detected fluorescence emission. Experiments with fish filets showed the applicability of the sensor foils in a real-life application by indicating the degree of spoilage after several days, while the microbial growth was depicted by total viable count. We anticipate that our sensor can be an integral part of smart food packages, helping to track the freshness of food during transport or storage.} } |
Sarah
Latus,
Sarah
Grube,
Tim
Eixmann,
Maximilian
Neidhardt,
Stefan
Gerlach,
Robin
Mieling,
Gereon
Hüttmann,
Matthias
Lutz, and
Alexander
Schlaefer,
A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography, IEEE Transactions on Biomedical Engineering , pp. 1-9, 05 2023.
A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography, IEEE Transactions on Biomedical Engineering , pp. 1-9, 05 2023.
DOI: | 10.1109/TBME.2023.3275539 |
Bibtex: | ![]() @ARTICLE{10122996, author={Latus, Sarah and Grube, Sarah and Eixmann, Tim and Neidhardt, Maximilian and Gerlach, Stefan and Mieling, Robin and Hüttmann, Gereon and Lutz, Matthias and Schlaefer, Alexander}, journal={IEEE Transactions on Biomedical Engineering}, title={A Miniature Dual-Fiber Probe for Quantitative Optical Coherence Elastography}, year={2023}, volume={}, number={}, pages={1-9}, doi={10.1109/TBME.2023.3275539}} |
Patrick
Kuppler,
Paul
Strenge,
Birgit
Lange,
Sonja
Spahr-Hess,
Wolfgang
Draxinger,
Christian
Hagel,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Robert
Huber,
Volker
Tronnier, and
Matteo Mario
Bonsanto,
The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study, Frontiers in Oncology , vol. 13, 04 2023.
The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study, Frontiers in Oncology , vol. 13, 04 2023.
DOI: | 10.3389/fonc.2023.1151149 |
Datei: | fonc.2023.1151149 |
Bibtex: | ![]() Kuppler P, Strenge P, Lange B, Spahr-Hess S, Draxinger W, Hagel C, Theisen-Kunde D, Brinkmann R, Huber R, Tronnier V and Bonsanto MM (2023) The neurosurgical benefit of contactless in vivo optical coherence tomography regarding residual tumor detection: A clinical study. Front. Oncol. 13:1151149. doi: 10.3389/fonc.2023.1151149 |
Norbert
Linz,
Sebastian
Freidank,
Xiao-Xuan
Liang, and
Alfred
Vogel,
Laser Micro- and Nanostructuring for Refractive Eye Surgery, in Ultrafast Laser Nanostructuring: The Pursuit of Extreme Scales , Stoian, Razvanand and Bonse, Jörn, Eds. Cham: Springer International Publishing, 042023, pp. 1217--1245.
Laser Micro- and Nanostructuring for Refractive Eye Surgery, in Ultrafast Laser Nanostructuring: The Pursuit of Extreme Scales , Stoian, Razvanand and Bonse, Jörn, Eds. Cham: Springer International Publishing, 042023, pp. 1217--1245.
DOI: | 10.1007/978-3-031-14752-4_33 |
ISBN: | 978-3-031-14752-4 |
Datei: | 978-3-031-14752-4_33 |
Bibtex: | ![]() @Inbook{Linz2023, author="Linz, Norbert and Freidank, Sebastian and Liang, Xiao-Xuan and Vogel, Alfred", editor="Stoian, Razvan and Bonse, J{\"o}rn", title="Laser Micro- and Nanostructuring for Refractive Eye Surgery", bookTitle="Ultrafast Laser Nanostructuring: The Pursuit of Extreme Scales", year="2023", publisher="Springer International Publishing", address="Cham", pages="1217--1245", abstract="Every year, more than a million refractive eye operations using femtosecond (fs) laser procedures are performed, and yet the cutting process in corneal tissue remains an area for development. In this chapter, we first review the state of the art of infrared (IR) fs laser dissection in laser in situ keratomileusis (LASIK) and small incision lenticule extraction (SMILE) and formulate the challenges for an improvement of precision and reduction of side effects. Since overcoming these challenges requires better knowledge of the cutting mechanisms, the plasma-mediated corneal dissection process is analyzed by high-speed photography of laser-induced bubble dynamics with up to 50 Mio frames/s, histological analysis of the cuts, and gas chromatography of the dissection products. Based on these results, we show that cutting efficiency and precision are improved through focus shaping by means of a helical phase plate, which converts the linear polarized Gaussian fs laser beam into a Laguerre-Gaussian vortex beam. The focus of the vortex beam has a ring shape with the same length in axial direction as the focus of a Gaussian beam but larger diameter. This greatly facilitates cleavage along the corneal lamellae, enabling cutting with low plasma energy density, higher precision, and fewer mechanical side effects. A shortening of the laser plasma length at constant focusing angle by use of UV-A laser pulses instead of IR pulses further improves precision. To compare the performance of UV and IR Gaussian and vortex beams, the incident and absorbed laser energy needed for easy removal of flaps created in porcine corneas are determined at various pulse durations and the smoothness of cuts is evaluated by scanning electron microscopy. Overall, vortex beams perform better than Gaussian beams for all wavelengths and can be easily implemented in clinical systems. Finally, we discuss a novel concept for refractive correction based on the introduction of refractive index changes in the corneal stroma by localized low-density plasma formation. Experimental findings that UV wavelengths work better for this purpose than IR wavelengths are explained through an analysis of the wavelength dependence of free electron density and energy spectrum that are obtained by numerical simulations.", isbn="978-3-031-14752-4", doi="10.1007/978-3-031-14752-4_33", url="https://doi.org/10.1007/978-3-031-14752-4_33" } |
Alessa
Hutfilz,
Dirk
Theisen-Kunde,
Matteo M.
Bonsanto, and
Ralf
Brinkmann,
Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection, Lasers in Medical Science , vol. 38, pp. 94, 03 2023.
Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection, Lasers in Medical Science , vol. 38, pp. 94, 03 2023.
DOI: | 10.1007/s10103-023-03747-9 |
Weblink: | https://doi.org/10.1007/s10103-023-03747-9 |
Bibtex: | ![]() @article{RN5430, author = {Hutfilz, Alessa;Theisen-Kunde, Dirk;Bonsanto, Matteo Mario and Brinkmann, Ralf}, title = {Pulsed thulium laser blood vessel haemostasis as an alternative to bipolar forceps during neurosurgical tumour resection}, journal = {Lasers in Medical Science}, volume = {38}, number = {1}, pages = {94}, ISSN = {1435-604X}, DOI = {10.1007/s10103-023-03747-9}, url = {https://doi.org/10.1007/s10103-023-03747-9}, year = {2023}, type = {Journal Article} } |
Wolfgang
Draxinger,
Dirk
Theisen-Kunde,
Lion
Schützeck,
Nicolas
Detrez,
Paul
Strenge,
Veit
Danicke,
Jessica
Kren,
Patrick
Kuppler,
Sonja
Spahr-Hess,
Matteo Mario
Bonsanto,
Ralf
Brinkmann, and
Robert
Huber,
High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time, in High-Speed Biomedical Imaging and Spectroscopy VIII , Kevin K. Tsia and Keisuke Goda, Eds. SPIE, 032023. pp. 123900D.
High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time, in High-Speed Biomedical Imaging and Spectroscopy VIII , Kevin K. Tsia and Keisuke Goda, Eds. SPIE, 032023. pp. 123900D.
DOI: | 10.1117/12.2648505 |
Bibtex: | ![]() @inproceedings{10.1117/12.2648505, author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Sch{\"u}tzeck and Nicolas Detrez and Paul Strenge and Veit Danicke and Jessica Kren and Patrick Kuppler and Sonja Spahr-Hess and Matteo Mario Bonsanto and Ralf Brinkmann and Robert Huber}, title = {{High speed 4D in-vivo OCT imaging of the human brain: creating high density datasets for machine learning toward identification of malign tissue in real time}}, volume = {12390}, booktitle = {High-Speed Biomedical Imaging and Spectroscopy VIII}, editor = {Kevin K. Tsia and Keisuke Goda}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {123900D}, abstract = {Neuro-surgery is challenged by the difficulties of determining brain tumor boundaries during excisions. Optical coherence tomography is investigated as an imaging modality for providing a viable contrast channel. Our MHz-OCT technology enables rapid volumetric imaging, suitable for surgical workflows. We present a surgical microscope integrated MHz-OCT imaging system, which is used for the collection of in-vivo images of human brains, with the purpose of being used in machine learning systems that shall be trained to identify and classify tumorous tissue.}, keywords = {optical coherence tomography, brain tumor, neurosurgery, machine learning, contrast augmentation, histology dataset, clinical study, in-vivo imaging}, year = {2023}, doi = {10.1117/12.2648505}, URL = {https://doi.org/10.1117/12.2648505} } |
Thomas
Gottschall,
Tobias
Meyer-Zedler,
Matthias
Eibl,
Tom
Pfeiffer,
Hubertus
Hakert,
Michael
Schmitt,
Robert
Huber,
Andreas
Tünnermann,
Jens
Limpert, and
Juergen
Popp,
Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy, The Journal of Physical Chemistry B , pp. null, 03 2023.
Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy, The Journal of Physical Chemistry B , pp. null, 03 2023.
DOI: | 10.1021/acs.jpcb.2c09115 |
Datei: | acs.jpcb.2c09115 |
Bibtex: | ![]() @article{doi:10.1021/acs.jpcb.2c09115, author = {Gottschall, Thomas and Meyer-Zedler, Tobias and Eibl, Matthias and Pfeiffer, Tom and Hakert, Hubertus and Schmitt, Michael and Huber, Robert and Tünnermann, Andreas and Limpert, Jens and Popp, Juergen}, title = {Ultrafast Spectral Tuning of a Fiber Laser for Time-Encoded Multiplex Coherent Raman Scattering Microscopy}, journal = {The Journal of Physical Chemistry B}, volume = {0}, number = {0}, pages = {null}, year = {0}, doi = {10.1021/acs.jpcb.2c09115}, note ={PMID: 36917762}, URL = {https://doi.org/10.1021/acs.jpcb.2c09115}, eprint = { https://doi.org/10.1021/acs.jpcb.2c09115} } |
Manabu
Yamamoto,
Yoko
Miura,
Kumiko
Hirayama,
Akika
Kyo,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann, and
Shigeru
Honda,
Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy, Life , vol. 13, no. 3, pp. 769, 03 2023.
Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy, Life , vol. 13, no. 3, pp. 769, 03 2023.
DOI: | 10.3390/life13030769 |
Datei: | 769 |
Bibtex: | ![]() @article{RN5362, author = {Yamamoto, Manabu;Miura, Yoko;Hirayama, Kumiko;Kyo, Akika;Kohno, Takeya;Theisen-Kunde, Dirk;Brinkmann, Ralf and Honda, Shigeru}, title = {Comparative Treatment Study on Macular Edema Secondary to Branch Retinal Vein Occlusion by Intravitreal Ranibizumab with and without Selective Retina Therapy}, journal = {Life}, volume = {13}, number = {3}, pages = {769}, ISSN = {2075-1729}, DOI = {10.3390/life13030769}, url = {https://www.mdpi.com/2075-1729/13/3/769}, year = {2023}, type = {Journal Article} } |
Marie
Klufts,
Simon
Lotz,
Muhammad Asim
Bashir,
Tom
Pfeiffer,
Alexander
Mlynek,
Wolfgang
Wieser,
Alexander
Chamorovskiy,
Vladimir
Shidlovski, and
Robert
Huber,
850 nm FDML: performance and challenges, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236705.
850 nm FDML: performance and challenges, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236705.
DOI: | 10.1117/12.2649646 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649646, author = {M. Klufts and S. Lotz and M. A. Bashir and T. Pfeiffer and A. Mlynek and W. Wieser and A. Chamorovskiy and V. Shidlovski and R. Huber}, title = {{850 nm FDML: performance and challenges}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236705}, abstract = {We demonstrate a Fourier domain mode locked (FDML) laser centered around 850 nm with a sweeping range of 50 nm, a fundamental repetition rate of 2×416 kHz and an output power of 2 mW. A new cavity design using three chirped Fiber Bragg gratings is required to overcome sweeping limitations caused by high dispersion. Other solutions to address challenges such as high loss and high polarization mode dispersion will be discussed along with performance. A main application of this laser will be retinal imaging, but it might also be applicable for TiCo-Raman and SLIDE microscopy. }, keywords = {Swept source, FDML, Laser, Ophthalmic imaging, OCT, 800 nm, retinal imaging, light sources}, year = {2023}, doi = {10.1117/12.2649646}, URL = {https://doi.org/10.1117/12.2649646} } |
Philipp
Lamminger,
Hubertus
Hakert,
Simon
Lotz,
Jan Philip
Kolb,
Tonio
Kutscher,
Sebastian
Karpf, and
Robert
Huber,
900 nm swept source FDML laser with kW peak power, in Fiber Lasers XX: Technology and Systems , V. R. Supradeepa, Eds. SPIE, 032023. pp. 124001I.
900 nm swept source FDML laser with kW peak power, in Fiber Lasers XX: Technology and Systems , V. R. Supradeepa, Eds. SPIE, 032023. pp. 124001I.
DOI: | 10.1117/12.2649663 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649663, author = {Philipp Lamminger and Hubertus Hakert and Simon Lotz and Jan Philip Kolb and Tonio Kutscher and Sebastian Karpf and Robert Huber}, title = {{900 nm swept source FDML laser with kW peak power}}, volume = {12400}, booktitle = {Fiber Lasers XX: Technology and Systems}, editor = {V. R. Supradeepa}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {124001I}, abstract = {A wavelength agile 900 nm 2.5 kW peak power fiber laser is created by four-wave mixing (FWM) in a photonic crystal fiber (PCF), while amplifying a 1300 nm Fourier-domain mode-locked (FDML) laser. The FWM process is pumped by a home-built 1064 nm master oscillator power amplifier (MOPA) laser and seeded by a home-built 1300 nm FDML laser, generating high power pulses at wavelengths, where amplification by active fiber media is difficult. The 900 nm pulses have a spectral linewidth of 70 pm, are tunable over 54 nm and have electronic pulse-to-pulse tuning capability. These pulses can be used for nonlinear imaging like two-photon or coherent anti-Stokes Raman microscopy (CARS) microscopy including spectro-temporal laser imaging by diffracted excitation (SLIDE) and time-encoded (Tico) stimulated Raman microscopy.}, keywords = {Fourier domain mode locking, FDML, Raman, two photon microscopy, SLIDE, 900 nm, fiber laser, photonic crystal fiber, swept source}, year = {2023}, doi = {10.1117/12.2649663}, URL = {https://doi.org/10.1117/12.2649663} } |
Muhammad Asim
Bashir,
Simon
Lotz,
Marie
Klufts,
Igor
Krestnikov,
Christian
Jirauschek, and
Robert
Huber,
1190 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236707.
1190 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT), in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236707.
DOI: | 10.1117/12.2652884 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652884, author = {M. A. Bashir and S. Lotz and M. Klufts and I. Krestnikov and C. Jirauschek and R. Huber}, title = {{1190 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT)}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236707}, abstract = {We demonstrate a Fourier domain mode locked (FDML) laser centered at 1190 nm with 2×410 kHz sweep repetition rate, a sweeping range of 100 nm and 2.5 mW output power. The laser is based on a quantum dot-semiconductor optical amplifier with small linewidth enhancement factor. The laser could be used as a probe laser in stimulated Raman scattering microscopy and it may be attractive for optical coherence tomography due to low water absorption and the spectral signature of lipids around 1200nm. Moreover, it is ideal to close the gap between FDML lasers at 1064 nm and 1300 nm. Combining these three lasers can enable ultrawideband sweeping to improve the axial OCT resolution down to 2 μm. }, keywords = {FDML, Swept source, laser, SS-OCT, OCT, Tunable lasers}, year = {2023}, doi = {10.1117/12.2652884}, URL = {https://doi.org/10.1117/12.2652884} } |
Awanish P.
Singh,
Madita
Göb,
Martin
Ahrens,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Robert
Huber, and
Maik
Rahlves,
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236703.
Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 1236703.
DOI: | 10.1117/12.2652955 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652955, author = {Awanish Pratap Singh and Madita G{\"o}b and Martin Ahrens and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H{\"u}ttmann and Robert Huber and Maik Rahlves}, title = {{Synchronous high-speed OCT imaging with sensor less brushless DC motor and FDML laser in a phase-locked loop}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236703}, abstract = {High-speed endoscopic optical coherence tomography (OCT) imaging in the MHz range has shown great potential in various medical applications ranging from cancer screening to vascular disease monitoring. High-speed imaging always suffers from non-uniform rotational distortion (NURD) due to asynchronous motor rotation with the OCT system. Several research groups have previously attempted to solve this problem, using either an expensive motor with a sensor or numerical correction after data acquisition. However, both techniques pose challenges for practical use. Therefore, in this study, we use an inexpensive sensorless brushless DC motor with a Fourier domain mode-locked (FDML) laser-based MHz OCT system and try to resolve the problem of synchronization using three different modalities, (i) Slave-mode: The FDML frequency serves as a master frequency for the motor, which is phase-locked to the FDML frequency, (ii) Master-mode: The revolution trigger obtained from the motor’s back electromotive force (BEMF) signal serves as a trigger signal for the OCT imaging system, (iii) Both: Fully synchronized setup, where the motor rotation is synchronized with the laser and the imaging system is synchronized with the motor to achieve phase-stable OCT imaging. The first case slightly fluctuates in live preview and imaging due to the absence of a revolution trigger, while the second has varying motor speeds. Therefore, we use the third case to phase-lock the motor with FDML and get a distortion-free live preview and image acquisition. Finally, we demonstrate high-speed SS-OCT structural imaging (at 3.3 MHz A-scan rates) of a finger with a 16 mm diameter probe (at 40,000 rpm).}, keywords = {Optical Coherence Tomography, Endoscopy, FDML , Closed Loop Motor Control, NURD compensation, Brushless DC Motor, Back Electromotive Force}, year = {2023}, doi = {10.1117/12.2652955}, URL = {https://doi.org/10.1117/12.2652955} } |
Sazgar
Burhan,
Nicolas
Detrez,
Katharina
Rewerts,
Madita
Göb,
Christian
Hagel,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 123680F.
Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 123680F.
DOI: | 10.1117/12.2648301 |
Bibtex: | ![]() @inproceedings{10.1117/12.2648301, author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Characterization of brain tumor tissue by time-resolved, phase-sensitive optical coherence elastography at 3.2 MHz line rate}}, volume = {12368}, booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI}, editor = {Caroline Boudoux and James W. Tunnell}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {123680F}, abstract = {Optical coherence elastography (OCE) offers the possibility of obtaining the mechanical behavior of a tissue. When also using a non-contact mechanical excitation, it mimics palpation without interobserver variability. One of the most frequently used techniques is phase-sensitive OCE. Depending on the system, depth-resolved changes in the sub-µm to nm range can be detected and visualized volumetrically. Such an approach is used in this work to investigate and detect transitions between healthy and tumorous brain tissue as well as inhomogeneities in the tumor itself to assist the operating surgeon during tumor resection in the future. We present time-resolved, phase-sensitive OCE measurements on various ex vivo brain tumor samples using an ultra-fast 3.2 MHz swept-source optical coherence tomography (SS-OCT) system with a frame rate of 2.45 kHz. 4 mm line scans are acquired which, in combination with the high imaging speed, allow monitoring and investigation of the sample's behavior in response to the mechanical load. Therefore, an air-jet system applies a 200 ms short air pulse to the sample, whose non-contact property facilitates the possibility for future in vivo measurements. Since we can temporally resolve the response of the sample over the entire acquisition time, the mechanical properties are evaluated at different time points with depth resolution. This is done by unwrapping the phase data and performing subsequent assessment. Systematic ex vivo brain tumor measurements were conducted and visualized as distribution maps. The study outcomes are supported by histological analyses and examined in detail.}, keywords = { Optical Coherence Tomography, Optical Coherence Elastography, Phase-sensitive OCT, Fourier Domain Mode Locking, Brain Tumor, Phase Unwrapping, Tissue Characterization, Biomechanics}, year = {2023}, doi = {10.1117/12.2648301}, URL = {https://doi.org/10.1117/12.2648301} } |
Madita
Göb,
Simon
Lotz,
Linh
Ha-Wissel,
Sazgar
Burhan,
Sven
Böttger,
Floris
Ernst,
Jennifer
Hundt, and
Robert
Huber,
Large area robotically assisted optical coherence tomography (LARA-OCT) for skin imaging with MHz-OCT surface tracking, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 123670C.
Large area robotically assisted optical coherence tomography (LARA-OCT) for skin imaging with MHz-OCT surface tracking, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032023. pp. 123670C.
DOI: | 10.1117/12.2652616 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652616, author = {Madita G{\"o}b and Simon Lotz and Linh Ha-Wissel and Sazgar Burhan and Sven B{\"o}ttger and Floris Ernst and Jennifer Hundt and Robert Huber}, title = {{Large area robotically assisted optical coherence tomography (LARA-OCT) for skin imaging with MHz-OCT surface tracking}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {123670C}, abstract = {Optical coherence tomography (OCT) is a powerful imaging technique to non-invasively differentiate between healthy skin and pathological conditions. Unfortunately, commercially available OCT-systems are typically slow and not capable of scanning large areas at reasonable speed. Since skin lesions may extend over several square centimeters, potential inflammatory infiltrates remain undetected. Here, we present large area robotically assisted OCT (LARA-OCT) for skin imaging. Therefor a collaborative robot is combined with an existing, home-built 3.3 MHz-OCT-system and for surface tracking an online probe-to-surface control is implemented which is solely based on the OCT surface signal. It features a combined surface-distance and surface-orientation closed-loop control algorithm, which enables automatic positioning and alignment of the probe across the target while imaging. This allows to acquire coherent OCT images of skin areas beyond 10 cm<sup>2</sup>. }, keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, Robotically Assisted Imaging Systems, Three-dimensional image acquisition, Large Area Scanning, Skin Imaging , OCT, FDML}, year = {2023}, doi = {10.1117/12.2652616}, URL = {https://doi.org/10.1117/12.2652616} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christian
Hagel,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 1236805.
Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography, in Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI , Caroline Boudoux and James W. Tunnell, Eds. SPIE, 032023. pp. 1236805.
DOI: | 10.1117/12.2649963 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649963, author = {Paul Strenge and Birgit Lange and Wolfgang Draxinger and Christian Hagel and Christin Grill and Veit Danicke and Dirk Theisen-Kunde and Sonja Spahr-Hess and Matteo M. Bonsanto and Robert Huber and Heinz Handels and Ralf Brinkmann}, title = {{Dual wavelength analysis and classification of brain tumor tissue with optical coherence tomography}}, volume = {12368}, booktitle = {Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XXI}, editor = {Caroline Boudoux and James W. Tunnell}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236805}, abstract = {The ill-defined tumor borders of glioblastoma multiforme pose a major challenge for the surgeon during tumor resection, since the goal of the tumor resection is the complete removal, while saving as much healthy brain tissue as possible. In recent years, optical coherence tomography (OCT) was successfully used to classify white matter from tumor infiltrated white matter by several research groups. Motivated by these results, a dataset was created, which consisted of sets of corresponding ex vivo OCT images, which were acquired by two OCT-systems with different properties (e.g. wavelength and resolution). Each image was annotated with semantic labels. The labels differentiate between white and gray matter and three different stages of tumor infiltration. The data from both systems not only allowed a comparison of the ability of a system to identify the different tissue types present during the tumor resection, but also enable a multimodal tissue analysis evaluating corresponding OCT images of the two systems simultaneously. A convolutional neural network with dirichlet prior was trained, which allowed to capture the uncertainty of a prediction. The approach increased the sensitivity of identifying tumor infiltration from 58 % to 78 % for data with a low prediction uncertainty compared to a previous monomodal approach. }, keywords = {optical coherence tomography, oct, brain, classification, tumor, dual wavelength, glioblastoma multiforme, tissue analysis}, year = {2023}, doi = {10.1117/12.2649963}, URL = {https://doi.org/10.1117/12.2649963} } |
Matthias
Strauch,
Jan Philip
Kolb,
Christian
Rose,
Nadine
Merg,
Jennifer
Hundt,
Christiane
Kümpers,
Sven
Perner,
Sebastian
Karpf, and
Robert
Huber,
Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy, European Journal of Surgical Oncology , vol. 49, no. 2, pp. e210, 02 2023.
Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy, European Journal of Surgical Oncology , vol. 49, no. 2, pp. e210, 02 2023.
DOI: | https://doi.org/10.1016/j.ejso.2022.11.575 |
Datei: | S0748798322013245 |
Bibtex: | ![]() @article{STRAUCH2023e210, title = {Accelerating intraoperative tumor histology with sectioning-free multiphoton microscopy}, journal = {European Journal of Surgical Oncology}, volume = {49}, number = {2}, pages = {e210}, year = {2023}, issn = {0748-7983}, doi = {https://doi.org/10.1016/j.ejso.2022.11.575}, url = {https://www.sciencedirect.com/science/article/pii/S0748798322013245}, author = {Matthias Strauch and Jan Philip Kolb and Christian Rose and Nadine Merg and Jennifer Hundt and Christiane Kümpers and Sven Perner and Sebastian Karpf and Robert Huber} } |
Leo
Puyo,
Clara
Pfäffle,
Hendrik
Spahr,
Jonas
Franke,
Daniel
Bublitz,
Dierck
Hillmann, and
Gereon
Hüttmann,
Diffuse-illumination holographic optical coherence tomography, Opt. Express , vol. 31, no. 20, pp. 33500--33517, 2023. Optica Publishing Group.
Diffuse-illumination holographic optical coherence tomography, Opt. Express , vol. 31, no. 20, pp. 33500--33517, 2023. Optica Publishing Group.
DOI: | 10.1364/OE.498654 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{Puyo:23, author = {L\'{e}o Puyo and Clara Pf\"{a}ffle and Hendrik Spahr and Jonas Franke and Daniel Bublitz and Dierck Hillmann and Gereon H\"{u}ttmann}, journal = {Opt. Express}, keywords = {Fourier optics; Full field optical coherence tomography; Image quality; Imaging techniques; Spatial frequency; Spatial light modulators}, number = {20}, pages = {33500--33517}, publisher = {Optica Publishing Group}, title = {Diffuse-illumination holographic optical coherence tomography}, volume = {31}, month = {Sep}, year = {2023}, url = {https://opg.optica.org/oe/abstract.cfm?URI=oe-31-20-33500}, doi = {10.1364/OE.498654}, abstract = {Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing diffuse illumination of numerical aperture (NA) equal to the detection NA. While the reduction of speckle from singly scattered light is only modest, we discovered that speckle from multiply scattered light can be arbitrarily reduced, resulting in substantial improvements in image quality. This technique also offers the advantage of suppressing noises arising from spatial coherence, and can be implemented with a partially spatially incoherent light source for further mitigation of multiple scattering. Finally, we show that although holographic reconstruction capabilities are increasingly lost with decreasing spatial coherence, they can be retained over an axial range sufficient to standard OCT applications.}, } |
Tonio F.
Kutscher,
Philipp
Lamminger,
Anton
Gruber,
Christina
Leonhardt,
Annika
Hunold,
Robert A.
Huber, and
Sebastian
Karpf,
Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm, Opt. Lett. , vol. 48, no. 23, pp. 6096--6099, 2023. Optica Publishing Group.
Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm, Opt. Lett. , vol. 48, no. 23, pp. 6096--6099, 2023. Optica Publishing Group.
DOI: | 10.1364/OL.500943 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{Kutscher:23, author = {Tonio F. Kutscher and Philipp Lamminger and Anton Gruber and Christina Leonhardt and Annika Hunold and Robert A. Huber and Sebastian Karpf}, journal = {Opt. Lett.}, keywords = {Erbium-doped fiber amplifiers; Laser imaging; Laser sources; Lidar; Multiphoton microscopy; Picosecond pulses}, number = {23}, pages = {6096--6099}, publisher = {Optica Publishing Group}, title = {Pulsed swept-source FDML-MOPA laser with kilowatt picosecond pulses around 1550 nm}, volume = {48}, month = {Dec}, year = {2023}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-48-23-6096}, doi = {10.1364/OL.500943}, abstract = {Swept-source lasers are versatile light sources for spectroscopy, imaging, and microscopy. Swept-source-powered multiphoton microscopy can achieve high-speed, inertia-free point scanning with MHz line-scan rates. The recently introduced spectro-temporal laser imaging by diffractive excitation (SLIDE) technique employs swept-source lasers to achieve kilohertz imaging rates by using a swept-source laser in combination with a diffraction grating for point scanning. Multiphoton microscopy at a longer wavelength, especially in the shortwave infrared (SWIR) region, can have advantages in deep tissue penetration or applications in light detection and ranging (LiDAR). Here we present a swept-source laser around 1550 nm providing high-speed wavelength agility and high peak power pulses for nonlinear excitation. The swept-source laser is a Fourier-domain mode-locked (FDML) laser operating at 326 kHz sweep rate. For high peak powers, the continuous wave (cw) output is pulse modulated to short picosecond pulses and amplified using erbium-doped fiber amplifiers (EDFAs) to peak powers of several kilowatts. This FDML-master oscillator power amplifier (FDML-MOPA) setup uses reliable, low-cost fiber components. As proof-of-principle measurement, we show third-harmonic generation (THG) using harmonic nanoparticles at the 10 MHz pulse excitation rate. This new, to the best of our knowledge, laser source provides unique performance parameters for applications in nonlinear microscopy, spectroscopy, and ranging.}, } |
Dirk
Theisen-Kunde,
Florian
Sommer,
Veit
Danicke,
Lion
Schützeck,
Stefan
Meyer,
Christopher
Kren,
Maximilian
Rixius, and
Sebastian
Karpf,
Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy, in Advances in Microscopic Imaging IV , Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park, Eds. SPIE, 2023. pp. 126300Q.
Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy, in Advances in Microscopic Imaging IV , Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park, Eds. SPIE, 2023. pp. 126300Q.
DOI: | 10.1117/12.2670881 |
Datei: | 12.2670881 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670881, author = {Dirk Theisen-Kunde and Florian Sommer and Veit Danicke and Lion Sch{\"u}tzeck and Stefan Meyer and Christopher Kren and Maximilian Rixius and Sebastian Karpf}, title = {{Small footprint SLIDE demonstrator for 40Hz volume rate multiphoton microscopy}}, volume = {12630}, booktitle = {Advances in Microscopic Imaging IV}, editor = {Emmanuel Beaurepaire and Adela Ben-Yakar and YongKeun Park}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126300Q}, keywords = {multiphoton microscopy, flow cytometry, Fourier Domain Mode Locked Laser, SLIDE, kHz- Imaging}, year = {2023}, doi = {10.1117/12.2670881}, URL = {https://doi.org/10.1117/12.2670881} } |
Sazgar
Burhan,
Nicolas
Detrez,
Katharina
Rewerts,
Madita
Göb,
Steffen
Buschschlüter,
Christian
Hagel,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Phase analysis strategies for MHz OCE in the large displacement regime, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 123670Q.
Phase analysis strategies for MHz OCE in the large displacement regime, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 123670Q.
DOI: | 10.1117/12.2652847 |
Bibtex: | ![]() @inproceedings{10.1117/12.2652847, author = {Sazgar Burhan and Nicolas Detrez and Katharina Rewerts and Madita G{\"o}b and Steffen Buschschl{\"u}ter and Christian Hagel and Matteo Mario Bonsanto M.D. and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Phase analysis strategies for MHz OCE in the large displacement regime}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {123670Q}, abstract = {In neurosurgical tumor operations on the central nervous system, intraoperative haptic information often assists for discrimination between healthy and diseased tissue. Thus, it can provide the neurosurgeon with additional intraoperative source of information during resection, next to the visual information by the light microscope, fluorescent dyes and neuronavigation. One approach to obtain elastic and viscoelastic tissue characteristics non-subjectively is phase-sensitive optical coherence elastography (OCE), which is based on the principle of optical coherence tomography (OCT). While phase-sensitive OCE offers significantly higher displacement sensitivity inside a sample than commonly used intensity-based correlation methods, it requires a reliable algorithm to recover the phase signal, which is mathematically restricted in the -π to π range. This problem of phase wrapping is especially critical for inter-frame phase analysis since the time intervals between two referenced voxels is long. Here, we demonstrate a one-dimensional unwrapping algorithm capable of removing up to 4π-ambiguities between two frames in the complex phase data obtained from a 3.2 MHz-OCT system. The high sampling rate allows us to resolve large sample displacements induced by a 200 ms air pulse and acquires pixel-precise detail information. The deformation behavior of the tissue can be monitored over the entire acquisition time, offering various subsequent mechanical analysis procedures. The reliability of the algorithm and imaging concept was initially evaluated using different brain tumor mimicking phantoms. Additionally, results from human ex vivo brain tumor samples are presented and correlated with histological findings supporting the robustness of the algorithm.}, keywords = {Optical Coherence Tomography, Megahertz OCT, Fourier Domain Mode Locking, Optical Coherence Elastography, Phase-sensitive OCT, Phase Unwrapping, Brain tumor, Biomechanics}, year = {2023}, doi = {10.1117/12.2652847}, URL = {https://doi.org/10.1117/12.2652847} } |
Dirk
Theisen-Kunde,
Claus
Burchard,
Veit
Danicke,
Jan-Eric
Fleger,
Christopher
Kren,
Sebastian
Wittmeier,
Johann
Roider, and
Ralf
Brinkmann,
Real-time temperature-control for cw retinal laser therapy in a clinical study, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 1262723.
Real-time temperature-control for cw retinal laser therapy in a clinical study, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 1262723.
DOI: | 10.1117/12.2670839 |
Datei: | 12.2670839 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670839, author = {Dirk Theisen-Kunde and Claus von der Burchard and Veit Danicke and Jan-Eric Fleger and Christopher Kren and Sebastian Wittmeier and Johann Roider and Ralf Brinkmann}, title = {{Real-time temperature-control for cw retinal laser therapy in a clinical study}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1262723}, keywords = {retinal laser, real time temperature control, clinical study, CSCR}, year = {2023}, doi = {10.1117/12.2670839}, URL = {https://doi.org/10.1117/12.2670839} } |
A. Martínez
Jiménez,
M.
Spacek,
Melanie
Wacker,
Robert
Huber,
A.
Bradu, and
Adrian
Podoleanu,
MHz time stretch swept source using a commercial erbium-doped fiber amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 1236706.
MHz time stretch swept source using a commercial erbium-doped fiber amplifier, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 2023. pp. 1236706.
DOI: | 10.1117/12.2651127 |
Datei: | 12.2651127 |
Bibtex: | ![]() @inproceedings{10.1117/12.2651127, author = {A. Mart{\'i}nez Jim{\'e}nez and M. Spacek and M. Wacker and R. Huber and A. Bradu and A. Podoleanu}, title = {{MHz time stretch swept source using a commercial erbium-doped fiber amplifier}}, volume = {12367}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1236706}, keywords = {swept source, time-stretch, optical coherence tomography, mode-locking}, year = {2023}, doi = {10.1117/12.2651127}, URL = {https://doi.org/10.1117/12.2651127} } |
Cuiping
Yao,
Xiao-Xuan
Liang,
Sijia
Wang,
Jing
Xin,
Luwei
Zhang, and
Zhenxi
Zhang,
Optical Theranostics Based on Gold Nanoparticles, in Biomedical Photonic Technologies , John Wiley & Sons, Ltd, 2023, pp. 245-284.
Optical Theranostics Based on Gold Nanoparticles, in Biomedical Photonic Technologies , John Wiley & Sons, Ltd, 2023, pp. 245-284.
DOI: | https://doi.org/10.1002/9783527823550.ch8 |
ISBN: | 9783527823550 |
Datei: | 9783527823550.ch8 |
Bibtex: | ![]() @inbook{doi:https://doi.org/10.1002/9783527823550.ch8, author = {Yao, Cuiping and Liang, Xiao-Xuan and Wang, Sijia and Xin, Jing and Zhang, Luwei and Zhang, Zhenxi}, publisher = {John Wiley & Sons, Ltd}, isbn = {9783527823550}, title = {Optical Theranostics Based on Gold Nanoparticles}, booktitle = {Biomedical Photonic Technologies}, chapter = {8}, pages = {245-284}, doi = {https://doi.org/10.1002/9783527823550.ch8}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/9783527823550.ch8}, eprint = {https://onlinelibrary.wiley.com/doi/pdf/10.1002/9783527823550.ch8}, year = {2023}, keywords = {localized surface plasmon resonance, thermo-plasmonic effect, optical imaging, molecular diagnosis, tumor treatment, precise manipulation}, abstract = {Summary To obtain more detailed images of cellular processes or other nanoscale information in the fields of biology and medicine, or to improve phototherapy of cancer, various nanoparticles have emerged as optical probes, contrast agents, or optical absorbing agents. Among different nanoparticles, gold nanoparticle has obtained great attention and application in biomedical fields, such as optoporation, photo imaging, photodiagnosis, and phototherapy, due to their unique tunable optical, surface plasmon resonance, and photothermal features. In this chapter, the general physical mechanism of thermoplasmonic effects of gold nanoparticles was introduced, and the gold nanoparticles enhanced optical imaging, detection, and phototherapy of tumors was summarized.} } |
Lara
Buhl,
Maron
Dolling,
Stefan
Kassumeh,
Siegfried G.
Priglinger,
Rox R.
Anderson,
Mark
Bischoff, and
Reginald
Birngruber,
Corneal filler injection for enhancement after myopic small-incision lenticule extraction (SMILE), 2023.
Corneal filler injection for enhancement after myopic small-incision lenticule extraction (SMILE), 2023.
DOI: | 10.1117/12.2649215 |
Christin
Grill,
Julie-Jacqueline
Kuhl,
Maximiliane Amelie
Schlenz, and
Ralf
Brinkmann,
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography, in Optical Coherence Imaging Techniques and Imaging in Scattering Media V , Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno, Eds. SPIE, 2023. pp. 126320J.
DOI: | 10.1117/12.2670874 |
Datei: | 12.2670874 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670874, author = {Christin Grill and Julie-Jacqueline Kuhl and Maximiliane Amelie Schlenz and Ralf Brinkmann}, title = {{Monitoring of fatigue damage in monolithic dental CAD/CAM crowns by optical coherence tomography}}, volume = {12632}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media V}, editor = {Benjamin J. Vakoc and Maciej Wojtkowski and Yoshiaki Yasuno}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126320J}, keywords = {Optical Coherence Tomography, OCT, Monolithic dental crowns, CAD/CAM materials, Microcracks, Non-destructive method, Fatigue damage, Dental materials}, year = {2023}, doi = {10.1117/12.2670874}, URL = {https://doi.org/10.1117/12.2670874} } |
Nicolas
Detrez,
Sazgar
Burhan,
Paul
Strenge,
Jessica
Kren,
Christian
Hagel,
Matteo Mario
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis, in Emerging Technologies for Cell and Tissue Characterization II , Seemantini K. Nadkarni and Giuliano Scarcelli, Eds. SPIE, 2023. pp. 126290M.
Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis, in Emerging Technologies for Cell and Tissue Characterization II , Seemantini K. Nadkarni and Giuliano Scarcelli, Eds. SPIE, 2023. pp. 126290M.
DOI: | 10.1117/12.2670944 |
Datei: | 12.2670944 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670944, author = {Nicolas Detrez and Sazgar Burhan and Paul Strenge and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Air-jet based optical coherence elastography of brain tumor tissue: stiffness evaluation by structural histological analysis}}, volume = {12629}, booktitle = {Emerging Technologies for Cell and Tissue Characterization II}, editor = {Seemantini K. Nadkarni and Giuliano Scarcelli}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126290M}, keywords = {Optical Coherence Elastography, Air-Jet, Phase-sensitive OCT, Histology Structure Analysis, Color-Deconvolution, Structural Tensors, Brain tumor, Tissue Characterization}, year = {2023}, doi = {10.1117/12.2670944}, URL = {https://doi.org/10.1117/12.2670944} } |
Nicolas
Detrez,
Sazgar
Burhan,
Katharina
Rewerts,
Jessica
Kren,
Christian
Hagel,
Matteo Mario
Bonsanto,
Dirk
Theisen-Kunde,
Robert
Huber, and
Ralf
Brinkmann,
Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data, in Optical Elastography and Tissue Biomechanics X , Kirill V. Larin and Giuliano Scarcelli and Frédérique Vanholsbeeck, Eds. SPIE, 2023. pp. 1238105.
Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data, in Optical Elastography and Tissue Biomechanics X , Kirill V. Larin and Giuliano Scarcelli and Frédérique Vanholsbeeck, Eds. SPIE, 2023. pp. 1238105.
DOI: | 10.1117/12.2649835 |
Datei: | 12.2649835 |
Bibtex: | ![]() @inproceedings{10.1117/12.2649835, author = {Nicolas Detrez and Sazgar Burhan and Katharina Rewerts and Jessica Kren and Christian Hagel and Matteo Mario Bonsanto and Dirk Theisen-Kunde and Robert Huber and Ralf Brinkmann}, title = {{Air-Jet based optical coherence elastography: processing and mechanical interpretation of brain tumor data}}, volume = {12381}, booktitle = {Optical Elastography and Tissue Biomechanics X}, editor = {Kirill V. Larin and Giuliano Scarcelli and Fr{\'e}d{\'e}rique Vanholsbeeck}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1238105}, keywords = {Optical Coherence Elastography, Air-Jet, Air-Puff, biomechanics, viscoelasticity, rheology, brain tissue, brain tumor}, year = {2023}, doi = {10.1117/12.2649835}, URL = {https://doi.org/10.1117/12.2649835} } |
Dirk
Theisen-Kunde,
Jessica
Kren,
Alessa
Hutfilz,
Matteo Mario
Bonsanto, and
Ralf
Brinkmann,
Clinical evaluation of thulium laser / ultrasonic aspirator combination instrument during neurosurgical tumour resection, 2023.
Clinical evaluation of thulium laser / ultrasonic aspirator combination instrument during neurosurgical tumour resection, 2023.
Weblink: | https://spie.org/european-conference-on-biomedical-optics/presentation/Clinical-evaluation-of-thulium-laser-ultrasonic-aspirator-combination-instrument-during/12627-34?SSO=1 |
Bibtex: | ![]() @inproceedings{RN5454, author = {Theisen-Kunde, D;Kren, J;Hutfilz, A;Bonsanto, M and Brinkmann, R}, title = {Clinical evaluation of thulium laser/ultrasonic aspirator combination instrument during neurosurgical tumour resection}, booktitle = {ECBO}, publisher = {SPIE}, url = {https://spie.org/european-conference-on-biomedical-optics/presentation/Clinical-evaluation-of-thulium-laser-ultrasonic-aspirator-combination-instrument-during/12627-34}, type = {Conference Proceedings} } |
Paula
Enzian,
Birgit
Lange,
Zuzana
Penxova,
Anke
Leichtle,
Yoko
Miura,
Karl-Ludwig
Bruchhage, and
Ralf
Brinkmann,
Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126271T.
Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126271T.
DOI: | 10.1117/12.2670902 |
Datei: | 12.2670902 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670902, author = {Paula Enzian and Birgit Lange and Zuzana Penxov{\'a} and Anke Leichtle and Yoko Miura and Karl-Ludwig Bruchhage and Ralf Brinkmann}, title = {{Fluorescence lifetime imaging microscopy (FLIM) of human middle ear tissue samples}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126271T}, keywords = {FLIM, autofluorescence, otitis media, cholesteatoma, middle ear, inflammation}, year = {2023}, doi = {10.1117/12.2670902}, URL = {https://doi.org/10.1117/12.2670902} } |
Alexander
Altmann,
Mohammad
Khodaygani,
Martin
Leucker,
Christian
Schell, and
Ramtin
Rahmanzadeh,
Fluorescence based detection of gaseous food spoilage indicators, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270I.
Fluorescence based detection of gaseous food spoilage indicators, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270I.
DOI: | 10.1117/12.2671751 |
Datei: | 12.2671751 |
Bibtex: | ![]() @inproceedings{10.1117/12.2671751, author = {Alexander Altmann and Mohammad Khodaygani and Martin Leucker and Christian Schell and Ramtin Rahmanzadeh}, title = {{Fluorescence based detection of gaseous food spoilage indicators}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126270I}, keywords = {fluorescence spectroscopy, gas sensing, optode technology, food safety, porphyrins, SVM classifier}, year = {2023}, doi = {10.1117/12.2671751}, URL = {https://doi.org/10.1117/12.2671751} } |
Wolfgang
Draxinger,
Dirk
Theisen-Kunde,
Lion
Schuetz,
Nicolas
Detrez,
Paul
Strenge,
Maximilian
Rixius,
Veit
Danicke,
Wolfgang
Wieser,
Jessica
Kren,
Patrick
Kuppler,
Sonja
Spar-Hess,
Matteo Mario Bonsanto
M.D.,
Ralf
Brinkmann, and
Robert
Huber,
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270W.
Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation, in Translational Biophotonics: Diagnostics and Therapeutics III , Zhiwei Huang and Lothar D. Lilge, Eds. SPIE, 2023. pp. 126270W.
DOI: | 10.1117/12.2670953 |
Datei: | 12.2670953 |
Bibtex: | ![]() @inproceedings{10.1117/12.2670953, author = {Wolfgang Draxinger and Dirk Theisen-Kunde and Lion Schuetz and Nicolas Detrez and Paul Strenge and Maximilian Rixius and Veit Danicke and Wolfgang Wieser and Jessica Kren and Patrick Kuppler and Sonja Spar-Hess and Matteo Mario Bonsanto M.D. and Ralf Brinkmann and Robert Huber}, title = {{Microscope integrated realtime high density 4D MHz-OCT in neurosurgery: a depth and tissue resolving visual contrast channel and the challenge of fused presentation}}, volume = {12627}, booktitle = {Translational Biophotonics: Diagnostics and Therapeutics III}, editor = {Zhiwei Huang and Lothar D. Lilge}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {126270W}, keywords = {optical coherence tomography, neurosurgery, tissue contrast, image fusion, surgical guidance, theranostics}, year = {2023}, doi = {10.1117/12.2670953}, URL = {https://doi.org/10.1117/12.2670953} } |
Lei
Fu,
Xiao-Xuan
Liang,
Sijia
Wang,
Siqi
Wang,
Ping
Wang,
Zhenxi
Zhang,
Jing
Wang,
Alfred
Vogel, and
Cuiping
Yao,
Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls, Ultrasonics Sonochemistry , vol. 101, pp. 106664, 2023.
Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls, Ultrasonics Sonochemistry , vol. 101, pp. 106664, 2023.
DOI: | https://doi.org/10.1016/j.ultsonch.2023.106664 |
Datei: | S1350417723003760 |
Bibtex: | ![]() @article{FU2023106664, title = {Laser induced spherical bubble dynamics in partially confined geometry with acoustic feedback from container walls}, journal = {Ultrasonics Sonochemistry}, volume = {101}, pages = {106664}, year = {2023}, issn = {1350-4177}, doi = {https://doi.org/10.1016/j.ultsonch.2023.106664}, url = {https://www.sciencedirect.com/science/article/pii/S1350417723003760}, author = {Lei Fu and Xiao-Xuan Liang and Sijia Wang and Siqi Wang and Ping Wang and Zhenxi Zhang and Jing Wang and Alfred Vogel and Cuiping Yao}, keywords = {Laser-induced cavitation, Partial confinement, Acoustic feedback, Elastic wall, Vibrations, Extended Rayleigh-Plesset model}, abstract = {We investigated laser-induced cavitation dynamics in a small container with elastic thin walls and free or partially confined surface both experimentally and by numerical investigations. The cuvette was only 8–25 times larger than the bubble in its center. The liquid surface was either free, or two thirds were confined by a piston-shaped pressure transducer. Different degrees of confinement were realized by filling the liquid up to the transducer surface or to the top of the cuvette. For reference, some experiments were performed in free liquid. We recorded the bubble dynamics simultaneously by high-speed photography, acoustic measurements, and detection of probe beam scattering. Simultaneous single-shot recording of radius-time curves and oscillation times enabled to perform detailed investigations of the bubble dynamics as a function of bubble size, acoustic feedback from the elastic walls, and degree of surface confinement. The bubble dynamics was numerically simulated using a Rayleigh-Plesset model extended by terms describing the acoustically mediated feedback from the bubble’s environment. Bubble oscillations were approximately spherical as long as no secondary cavitation by tensile stress occurred. Bubble expansion was always similar to the dynamics in free liquid, and the environment influenced mainly the collapse phase and subsequent oscillations. For large bubbles, strong confinement led to a slight reduction of maximum bubble size and to a pronounced reduction of the oscillation time, and both effects increased with bubble size. The joint action of breakdown-induced shock wave and bubble expansion excites cuvette wall vibrations, which produce alternating pressure waves that are focused onto the bubble. This results in a prolongation of the collapse phase and an enlargement of the second oscillation, or in time-delayed re-oscillations. The details of the bubble dynamics depend in a complex manner on the degree of surface confinement and on bubble size. Numerical simulations of the first bubble oscillation agreed well with experimental data. They suggest that the alternating rarefaction/compression waves from breakdown-induced wall vibrations cause a prolongation of the first oscillation. By contrast, liquid mass movement in the cuvette corners result in wall vibrations causing late re-oscillations. The strong and rich interaction between the bubble and its surroundings may be relevant for a variety of applications such as intraluminal laser surgery and laser-induced cavitation in microfluidics.} } |
Stefan
Meyer,
Tonio F.
Kutscher,
Philipp
Lamminger,
Florian
Sommer, and
Sebastian
Karpf,
Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation, Opt. Continuum , vol. 2, no. 11, pp. 2298--2307, 2023. Optica Publishing Group.
Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation, Opt. Continuum , vol. 2, no. 11, pp. 2298--2307, 2023. Optica Publishing Group.
DOI: | 10.1364/OPTCON.500969 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{Meyer:23, author = {Stefan Meyer and Tonio F. Kutscher and Philipp Lamminger and Florian Sommer and Sebastian Karpf}, journal = {Opt. Continuum}, keywords = {Femtosecond pulses; Fluorescence lifetime imaging; Phase modulation; Picosecond pulses; Single mode lasers; Ultrashort pulses}, number = {11}, pages = {2298--2307}, publisher = {Optica Publishing Group}, title = {Leveraging the periodic interference condition in electro-optic modulators for picosecond pulse generation}, volume = {2}, month = {Nov}, year = {2023}, url = {https://opg.optica.org/optcon/abstract.cfm?URI=optcon-2-11-2298}, doi = {10.1364/OPTCON.500969}, abstract = {Ultra-short optical pulses in the femtosecond and picosecond regime are typically generated using mode-locked lasers. However, in mode-locking, the pulse repetition rate is fundamentally linked to the cavity length of the laser, making it difficult to synchronize these laser pulses to other light sources. Here, we apply a pulse-on-demand approach to picosecond pulse generation with an electro-optic intensity modulator (EOM). The high, 40 GHz bandwidth of the EOM enables low picosecond pulses, however it shifts the problem of pulse generation to the electronic pulses, requiring high bandwidth electronics. In this study, we present an electro-optic operation, leveraging the periodic interference condition of intensity EOMs by operating it with rising edges at twice its V$\pi$ voltage. Utilizing this method, pulse durations as short as 10.9 ps were achieved by employing a 35 ps edge from an arbitrary waveform generator. The pulses were measured directly on a high-speed oscilloscope as well as indirectly through the spectral broadening of the generated optical pulses. We employ this approach to show arbitrary pulse length generation by applying step functions with only one V$\pi$ voltage, thus permitting direct pulse-on-demand generation of pulses with arbitrary pulse length, shape and repetition rate for applications in spectroscopy, sensing and nonlinear imaging.}, } |
2022
Özüm Emre
Aşırım,
Robert
Huber, and
Christian
Jirauschek,
Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers, Applied Physics B , vol. 18(12), Nov. 2022.
Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers, Applied Physics B , vol. 18(12), Nov. 2022.
DOI: | 10.1007/s00340-022-07933-5 |
Bibtex: | ![]() @article{RN5426, author = {Aşırım, Özüm Emre;Huber, Robert and Jirauschek, Christian}, title = {Influence of the linewidth enhancement factor on the signal pattern of Fourier domain mode-locked lasers}, journal = {Applied Physics B}, volume = {128}, number = {12}, pages = {218}, ISSN = {1432-0649}, DOI = {10.1007/s00340-022-07933-5}, url = {https://doi.org/10.1007/s00340-022-07933-5}, year = {2022}, type = {Journal Article} } |
Caren
Jacobi,
Madita
Göb,
Robert
Huber,
Ralf. J.
Ludwig, and
Jennifer
Hundt,
620 Screening an inhibitor library for new drug candidates to promote wound healing, Journal of Investigative Dermatology , vol. 142, no. 12, Supplement, pp. S288, Nov. 2022.
620 Screening an inhibitor library for new drug candidates to promote wound healing, Journal of Investigative Dermatology , vol. 142, no. 12, Supplement, pp. S288, Nov. 2022.
DOI: | https://doi.org/10.1016/j.jid.2022.09.637 |
Datei: | S0022202X22025714 |
Bibtex: | ![]() @article{JACOBI2022S288, title = {620 Screening an inhibitor library for new drug candidates to promote wound healing}, journal = {Journal of Investigative Dermatology}, volume = {142}, number = {12, Supplement }, pages = {S288}, year = {2022}, note = {ESDR 2022 Meeting Abstract Supplement}, issn = {0022-202X}, doi = {https://doi.org/10.1016/j.jid.2022.09.637}, url = {https://www.sciencedirect.com/science/article/pii/S0022202X22025714}, author = {C. Jacobi and M. Göb and R. Huber and R.J. Ludwig and J.E. Hundt} } |
Linh
Ha-Wissel,
Handan
Yasak,
Robert
Huber,
Detlef
Zillikens,
Ralf J.
Ludwig,
Diamant
Thaci, and
Jennifer E.
Hundt,
Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis, Frontiers in Medicine , vol. 9, 09 2022.
Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis, Frontiers in Medicine , vol. 9, 09 2022.
DOI: | 10.3389/fmed.2022.995883 |
Datei: | fmed.2022.995883 |
Bibtex: | ![]() @article{RN5359, author = {Ha-Wissel, L.;Yasak, H.;Huber, R.;Zillikens, D.;Ludwig, R. J.;Thaçi, D. and Hundt, J. E.}, title = {Case report: Optical coherence tomography for monitoring biologic therapy in psoriasis and atopic dermatitis}, journal = {Front Med (Lausanne)}, volume = {9}, pages = {995883}, ISSN = {2296-858X (Print) 2296-858x}, DOI = {10.3389/fmed.2022.995883}, year = {2022}, type = {Journal Article} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Christin
Grill,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Heinz
Handels,
Ralf
Brinkmann, and
Robert
Huber,
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology, Frontiers in Oncology , 08 2022.
DOI: | 10.3389/fonc.2022.896060 |
Bibtex: | ![]() @article{Strenge-2022, author = {Strenge, P.;Lange, B.;Grill,C.;Danicke,V.;Theisen-Kunde, D.;Hagel, C.;Spahr-Hess, S.;;Bonsanto, Matteo M.;Handels, H.; and Huber, R.;Brinkmann, R.}, title = {Differentiation of different stages of brain tumor infiltration using optical coherence tomography: Comparison of two systems and histology}, journal = {Frontiers in Oncology}, Keywords = {AG-Huber_FDML, AG-Huber_OCT, brain, tumor, glioblastoma multiforme, OCT, neural network, attenuation (absorption) coefficient, optical coherence tomography}, DOI = {https://doi.org/10.3389/fonc.2022.896060}, url = {https://www.frontiersin.org/articles/10.3389/fonc.2022.896060/full}, year = {2022}, type = {Journal Article} } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
Towards phase-stabilized Fourier domain mode-locked frequency combs, Communications Physics , vol. 5, no. 1, 08 2022. Springer Science and Business Media LLC.
DOI: | 10.1038/s42005-022-00960-w |
Bibtex: | ![]() @article{Grill2022, doi = {10.1038/s42005-022-00960-w}, year = {2022}, publisher = {Springer Science and Business Media {LLC}}, volume = {{5}}, number = {{1}}, author = {C. Grill, T. Bl\"{o}mker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {Towards phase-stabilized Fourier domain mode-locked frequency combs}, journal = {{Communications Physics}}, keywords={AG-Huber_FDML, FDML, Fourier domain mode locking, phase, frequency comb, coherence, beating} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Christian
Hagel,
Sonja
Spahr-Hess,
Matteo M.
Bonsanto,
Robert
Huber,
Heinz
Handels, and
Ralf
Brinkmann,
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
Registration of histological brain images onto optical coherence tomography images based on shape information, Physics in Medicine & Biology , 06 2022.
DOI: | 10.1088/1361-6560/ac6d9d |
Bibtex: | ![]() @article{Strenge2022, author = {Strenge, P;Lange, B;Grill, C;Draxinger, W;Danicke, V;Theisen-Kunde, D;Hagel, C;Spahr-Hess, S;Bonsanto, Matteo M.;Huber, R;Handels, H and Brinkmann, R}, title = {Registration of histological brain images onto optical coherence tomography images based on shape information}, keywords = {brain, glioblastoma multiforme, shape, OCT, optical coherence tomography, AG-Huber_OCT,}, journal = {Physics in Medicine & Biology}, ISSN = {0031-9155}, url = {http://iopscience.iop.org/article/10.1088/1361-6560/ac6d9d}, year = {2022}, type = {Journal Article} } |
Clara
Pfäffle,
Hendrik
Spahr,
Katharina
Gercke,
Leo
Puyo,
Svea
Höhl,
David
Melenberg,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer, Frontiers in Medicine , vol. 9, 06 2022.
Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer, Frontiers in Medicine , vol. 9, 06 2022.
DOI: | 10.3389/fmed.2022.885187 |
Datei: | fmed.2022.885187 |
Bibtex: | ![]() @article{RN5328, author = {Pfäffle, C;Spahr, H;Gercke, K;Puyo, L;Höhl, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Phase-Sensitive Measurements of Depth-Dependent Signal Transduction in the Inner Plexiform Layer}, journal = {Frontiers in Medicine}, volume = {9}, ISSN = {2296-858X}, DOI = {10.3389/fmed.2022.885187}, keywords = {optoretinography, optical coherence tomography, phase-sensitive OCT, functional imaging, inner plexiform layer, retina}, url = {https://www.frontiersin.org/articles/10.3389/fmed.2022.885187}, year = {2022}, type = {Journal Article} } |
Madita
Göb,
Sazgar
Burhan,
Simon
Lotz, and
Robert
Huber,
Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032022. pp. 27 -- 31.
Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032022. pp. 27 -- 31.
DOI: | 10.1117/12.2612171 |
Bibtex: | ![]() @inproceedings{10.1117/12.2612171, author = {Madita G{\"o}b and Sazgar Burhan and Simon Lotz and Robert Huber}, title = {{Towards ultra-large area vascular contrast skin imaging using multi-MHz-OCT}}, volume = {11948}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {1194807}, abstract = {We demonstrate ultra-large field of view OCT scanning using standard optics, a X-Y-galvanometer scanner and a synchronously driven motorized XYZ-positioning stage. The integration of a movable stage into our self-built 3.3 MHz- OCT system allows acquiring coherent ultra-large area images, fully leveraging the high speed potential of our system. For fast OCT-angiography, one galvanometer axis scanner is driven in a repetitive sawtooth pattern, fully synchronized to the movement of the linear stage, to obtain multiple measurements at each position. This technique requires exact synchronization, precise repositioning, and uniform movements with low tolerances to ensure a minimum revisitation error. We analyze error and performance of our setup and demonstrate angiographic imaging.}, keywords = {Optical Coherence Tomography, Fourier Domain Mode Locking, FDML, Optical Coherence Angiography, OCTA, Medical optics and biotechnology, Medical imaging, Three-dimensional image acquisition, Scanners, Microscopy}, year = {2022}, doi = {10.1117/12.2612171}, URL = {https://doi.org/10.1117/12.2612171} } |
Marie
Klufts,
Simon
Lotz,
Muhammad Asim
Bashir,
Sebastian
Karpf, and
Robert
Huber,
Ultra-high-accuracy chromatic dispersion measurement in optical fibers, in Optical Components and Materials XIX , Shibin Jiang and Michel J. F. Digonnet, Eds. SPIE, 032022. pp. 119970L.
Ultra-high-accuracy chromatic dispersion measurement in optical fibers, in Optical Components and Materials XIX , Shibin Jiang and Michel J. F. Digonnet, Eds. SPIE, 032022. pp. 119970L.
DOI: | 10.1117/12.2608773 |
Bibtex: | ![]() @inproceedings{10.1117/12.2608773, author = {M. Klufts and S. Lotz and M. Bashir and S. Karpf and R. Huber}, title = {{Ultra-high-accuracy chromatic dispersion measurement in optical fibers}}, volume = {11997}, booktitle = {Optical Components and Materials XIX}, editor = {Shibin Jiang and Michel J. F. Digonnet}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {119970L}, abstract = {The chromatic dispersion in optical fibers is a key property for applications where a broadband light source is used and the timing of each individual wavelength is crucial. Counteracting the timing offset introduced by the fiber is a challenge in many applications especially in mode locked lasers. The dispersion parameters need to be measured with high precision. The length of the fiber, the temperature, and the used wavelength will highly impact the amount of dispersion and the accuracy of the measurement. We developed an ultra-high-accuracy dispersion measurement setup at 1080 ± 50 nm considering all the parameters that may influence the measurement. It is based on a home-built wavelength tunable laser where the output is modulated by an electro-optical modulator connected to a 24 GSamples/s arbitrary waveform generator to a complex pattern consisting of pulses and a 4 GHz sine wave. After passing through the fiber the signal is measured with an 80 GSamples/s real time oscilloscope. The fiber’s temperature is controlled to allow for reproducible measurements over several days and we achieve timing measurement accuracies down to ~200 fs. We also present the performance of the setup at ~850 nm. We will discuss and quantify all effects which can negatively impact the system accuracy and we will report on more cost-effective options using lower performance equipment.}, keywords = {Dispersion measurement, Chromatic dispersion, fiber dispersion measurement, optical component characterization, tunable laser, FDML}, year = {2022}, doi = {10.1117/12.2608773}, URL = {https://doi.org/10.1117/12.2608773} } |
Aaron Doug
Deen,
Heleen
van Beusekom,
Tom
Pfeiffer,
Mathijs
Stam,
Dominique
de Kleijn,
Jolanda
Wentzel,
Robert
Huber,
Antonius F. W.
van der Steen,
Gijs
van Soest, and
Tianshi
Wang,
Spectroscopic thermo-elastic optical coherence tomography for tissue characterization, Biomedical Optics Express , vol. 13(3), pp. 1430-1446, 02 2022.
Spectroscopic thermo-elastic optical coherence tomography for tissue characterization, Biomedical Optics Express , vol. 13(3), pp. 1430-1446, 02 2022.
DOI: | 10.1364/BOE.447911 |
Bibtex: | ![]() @article{Deen2022, author = {Deen, A D;Van Beusekom, H M. M.;Pfeiffer, T;Stam, M;Kleijn, D De;Wentzel, J;Huber, R;Van Der Steen, A F. W.;Soest, G Van and Wang, T}, title = {Spectroscopic thermo-elastic optical coherence tomography for tissue characterization}, journal = {BioOptExpr}, keywords = {AG-Huber, Endoscopic imaging, Image processing, Image quality, Imaging techniques, Optical imaging, Tissue characterization}, volume = {13(3)}, pages = {1430-1446}, DOI = {10.1364/BOE.447911}, year = {2022}, type = {Journal Article} } |
Madita
Göb,
Tom
Pfeiffer,
Wolfgang
Draxinger,
Simon
Lotz,
Jan Philip
Kolb, and
Robert
Huber,
Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence, Biomed. Opt. Express , vol. 13, no. 2, pp. 713--727, 02 2022. OSA.
Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence, Biomed. Opt. Express , vol. 13, no. 2, pp. 713--727, 02 2022. OSA.
DOI: | 10.1364/BOE.448353 |
Bibtex: | ![]() @article{Gob:22, author = {Madita G\"{o}b and Tom Pfeiffer and Wolfgang Draxinger and Simon Lotz and Jan Philip Kolb and Robert Huber}, journal = {Biomed. Opt. Express}, keywords = {High speed imaging; Image processing; Image quality; In vivo imaging; Range imaging; Vertical cavity surface emitting lasers}, number = {2}, pages = {713--727}, publisher = {Optica Publishing Group}, title = {Continuous spectral zooming for in vivo live 4D-OCT with MHz A-scan rates and long coherence}, volume = {13}, month = {Feb}, year = {2022}, url = {https://opg.optica.org/boe/abstract.cfm?URI=boe-13-2-713}, doi = {10.1364/BOE.448353}, abstract = {We present continuous three-dimensional spectral zooming in live 4D-OCT using a home-built FDML based OCT system with 3.28 MHz A-scan rate. Improved coherence characteristics of the FDML laser allow for imaging ranges up to 10 cm. For the axial spectral zoom feature, we switch between high resolution and long imaging range by adjusting the sweep range of our laser. We present a new imaging setup allowing for synchronized adjustments of the imaging range and lateral field of view during live OCT imaging. For this, a novel inline recalibration algorithm was implemented that enables numerical k-linearization of the raw OCT fringes for every frame instead of every volume. This is realized by acquiring recalibration data within the dead time of the raster scan at the turning points of the fast axis scanner. We demonstrate in vivo OCT images of fingers and hands at different resolution modes and show real three-dimensional zooming during live 4D-OCT. A three-dimensional spectral zooming feature for live 4D-OCT is expected to be a useful tool for a wide range of biomedical, scientific and research applications, especially in OCT guided surgery.}, } |
Konstantin
Yashin,
Matteo Mario
Bonsanto,
Ksenia
Achkasova,
Anna
Zolotova,
Al-Madhaji
Wael,
Elena
Kiseleva,
Alexander
Moiseev,
Igor
Medyanik,
Leonid
Kravets,
Robert
Huber,
Ralf
Brinkmann, and
Natalia
Gladkova,
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives, Diagnostics , vol. 12, no. 2, pp. 335, 01 2022.
DOI: | 10.3390/diagnostics12020335 |
Datei: | 335 |
Bibtex: | ![]() @article{Yashin-2022, author = {Yashin, K;Bonsanto, M M;Achkasova, K;Zolotova, A;Wael, Al-M;Kiseleva, E;Moiseev, A;Medyanik, I;Kravets, L;Huber, R;Brinkmann, R and Gladkova, N}, title = {OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives}, journal = {Diagnostics}, volume = {12}, number = {2}, pages = {335}, ISSN = {2075-4418}, keywords = {AG-Huber; optical coherence tomography; brain imaging; neurosurgical guidance; brain tumor; minimally invasive theranostics; intraoperative imaging}, url = {https://www.mdpi.com/2075-4418/12/2/335}, year = {2022}, type = {Journal Article} } |
Birgit
Lange,
Tomasz
Ozimek,
Judith R.
Wießmeyer,
Mario W.
Kramer,
Axel S.
Merseburger, and
Ralf
Brinkmann,
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy, Biomedical Physics & Engineering Express , vol. 8, no. 5, pp. 055023, 2022.
DOI: | 10.1088/2057-1976/ac82c7 |
Bibtex: | ![]() @article{Lange2022, author = {Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W.;Merseburger, A S. and Brinkmann, R}, title = {Theoretical and experimental evaluation of the distance dependence of fiber-based fluorescence and reflection measurements for laser lithotripsy}, journal = {Biomedical Physics & Engineering Express}, volume = {8}, number = {5}, abstract = {Objectives. In laser lithotripsy, a green aiming beam overlying the infrared (IR) treatment radiation gives rise to reflection and fluorescence signals that can be measured via the treatment fiber. While stone autofluorescence is used for target detection, the condition of the fiber can be assessed based on its Fresnel reflection. For good applicability, fluorescence detection of stones should work even when the stone and fiber are not in direct contact. Fiber breakage detection, on the other hand, can be falsified if surfaces located in front of the fiber reflect light from the aiming laser back into it. For both applications, therefore, a fundamental investigation of the dependence of the signal amplitude on the distance between fiber and surface is important. Methods. Calculations of the signal drop of fluorescence or diffuse and specular reflection with increasing fiber distance were performed using ray tracing based on a simple geometric model for different fiber core diameters. Reflection signals from a mirror, diffuse reflector, human calculi, and porcine renal tissue placed in water were measured at varying distances (0–5 mm). For human calculi, fluorescence signals were recorded simultaneously. Results. The calculations showed a linear signal decrease down to ∼60% of the maximum signal (fiber in contact). The distance z at which the signal drops to for example 50% depends linearly on the diameter of the fiber core. For fibers used in lithotripsy and positioned in water, z50% ranges from 0.55 mm (200 μm core diameter) to 2.73 mm, (1 mm core diameter). The calculations were in good agreement with the experimental results. Conclusions. The autofluorescence signals of stones can be measured in non-contact mode. Evaluating the Fresnel signal of the end face of the fiber to detect breakage is possible unless the fiber is situated less than some millimeters to reflecting surfaces.}, keywords = {urolithiasis, laser lithotripsy, fluorescence, reflectance}, pages = {055023}, ISSN = {2057-1976}, DOI = {10.1088/2057-1976/ac82c7}, year = {2022}, type = {Journal Article} } |
Yoko
Miura,
Keiji
Inagaki,
Alessa
Hutfilz,
Eric
Seifert,
Benedikt
Schmarbeck,
Akira
Murakami,
Kishiko
Ohkoshi, and
Ralf
Brinkmann,
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application, Life , vol. 12(9), pp. 1313, 2022.
DOI: | https://doi.org/10.3390/life12091313 |
Datei: | 1313 |
Bibtex: | ![]() @article{Miura2022, author = {Miura, Y;Inagaki, K;Hutfilz, A;Seifert, E;Schmarbeck, B;Murakami, A;Ohkoshi, K and Brinkmann, R}, title = {Temperature Increase and Damage Extent at Retinal Pigment Epithelium Compared between Continuous Wave and Micropulse Laser Application}, journal = {Life}, volume = {12(9)}, pages = {1313}, ISSN = {2075-1729}, url = {https://www.mdpi.com/2075-1729/12/9/1313}, year = {2022}, type = {Journal Article} } |
Claus
von der Burchard,
Helge
Sudkamp,
Jan
Tode,
Christoph
Ehlken,
K.
Purtskhvanidze,
Moritz
Moltmann,
B.
Heimes,
Peter
Koch,
Michael
Münst,
Malte
vom Endt,
Timo
Kepp,
Dirk
Theisen-Kunde,
Inke R.
König,
Gereon
Hüttmann, and
Johann
Roider,
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study, BMJ Open , vol. 12, no. 6, pp. e055082, 2022.
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study, BMJ Open , vol. 12, no. 6, pp. e055082, 2022.
DOI: | 10.1136/bmjopen-2021-055082 |
Datei: | e055082.abstract |
Bibtex: | ![]() @article{von-der-Burchardt2022, author = {von der Burchard, C;Sudkamp, H;Tode, J;Ehlken, C;Purtskhvanidze, K;Moltmann, M;Heimes, B;Koch, P;Münst, M;vom Endt, M;Kepp, T;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J}, title = {Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study}, journal = {BMJ Open}, volume = {12}, number = {6}, pages = {e055082}, DOI = {10.1136/bmjopen-2021-055082}, url = {http://bmjopen.bmj.com/content/12/6/e055082.abstract}, year = {2022}, type = {Journal Article} } |
S.
Freidank, and
N.
Linz,
Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second, BioOptExpr , vol. 13 (5), pp. 3056-3079, 2022.
Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second, BioOptExpr , vol. 13 (5), pp. 3056-3079, 2022.
DOI: | 10.1364/BOE.455926 |
Bibtex: | ![]() @article{Freidank2022, author = {Freidank, S;Vogel, A and Linz, N}, title = {Mechanisms of corneal intrastromal laser dissection for refractive surgery: ultra-high-speed photographic investigation at up to 50 million frames per second}, journal = {BioOptExpr}, volume = {13 (5)}, pages = {3056-3079}, DOI = {10.1364/BOE.455926}, year = {2022}, type = {Journal Article} } |
X-X
Liang, and
A
Vogel,
Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment, Optica , vol. 9(8), pp. 868-871, 2022.
Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment, Optica , vol. 9(8), pp. 868-871, 2022.
DOI: | 10.1364/OPTICA.454469 |
Bibtex: | ![]() @article{Liang2022, author = {Liang, X-X and Vogel, A}, title = {Probing neuronal functions with precise and targeted laser ablation in the living cortex: comment}, journal = {Optica}, volume = {9(8)}, keywords = {Attenuation coefficient, Femtosecond lasers, Laser ablation, Laser irradiation, Numerical simulation, Thermal effects}, pages = {868-871}, DOI = {10.1364/OPTICA.454469}, year = {2022}, type = {Journal Article} } |
Manuel A.
Schaller,
Mitsuru
Wilson,
Viktoria
Kleymann,
Mario
Mordmüller,
Ralf
Brinkmann,
Matthias A.
Müller, and
Karl
Worthmann,
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
Parameter estimation and model reduction for model predictive control in retinal laser treatment, Control Engineering Practice , vol. 128, pp. 105320, 2022.
DOI: | https://doi.org/10.1016/j.conengprac.2022.105320 |
Bibtex: | ![]() @article{Schaller2022, author = {Schaller, M;Wilson, M;Kleyman, V;Mordmüller, M;Brinkmann, R;Müller, M. A. and Worthmann, K}, title = {Parameter estimation and model reduction for model predictive control in retinal laser treatment}, journal = {Control Engineering Practice}, volume = {128}, pages = {105320}, ISSN = {0967-0661}, DOI = {https://doi.org/10.1016/j.conengprac.2022.105320}, year = {2022}, type = {Journal Article} } |
Manuel A.
Schaller,
Viktoria
Kleymann,
Mario
Mordmüller,
Schmidt
Christian,
Mitsuru
Wilson,
Ralf
Brinkmann,
Matthias A.
Müller, and
Karl
Worthmann,
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
Model predictive control for retinal laser treatment at 1 kHz, at - Automatisierungstechnik , vol. 70(11), pp. 992-1002, 2022.
Datei: | auto-2022-0030 |
Bibtex: | ![]() @article{Schaller2022, author = {Schaller, M.;Kleyman, K.;Mordmüller, M.;Schmidt, C.;Wilson, M.;Brinkmann, R.;Müller, M.A. and Worthmann, K.}, title = {Model predictive control for retinal laser treatment at 1 kHz}, journal = {at - Automatisierungstechnik}, volume = {70(11)}, keywords = {model predictive control; real-time control;retinal photocoagulation}, pages = {992-1002}, url = {https://doi.org/10.1515/auto-2022-0030}, year = {2022}, type = {Journal Article} } |
Tianshi
Wang,
Tom
Pfeiffer,
Ali
Akyildiz,
Heleen M. M.
Beusekom,
Robert
Huber,
Antonius F. W.
Steen, and
Gijs
Soest,
Intravascular optical coherence elastography, Biomed. Opt. Express , vol. 13, no. 10, pp. 5418--5433, 2022. Optica Publishing Group.
Intravascular optical coherence elastography, Biomed. Opt. Express , vol. 13, no. 10, pp. 5418--5433, 2022. Optica Publishing Group.
DOI: | 10.1364/BOE.470039 |
Datei: | abstract.cfm |
Bibtex: | ![]() Optical coherence elastography (OCE), a functional extension of optical coherence tomography (OCT), visualizes tissue strain to deduce the tissue’s biomechanical properties. In this study, we demonstrate intravascular OCE using a 1.1 mm motorized catheter and a 1.6 MHz Fourier domain mode-locked OCT system. We induced an intraluminal pressure change by varying the infusion rate from the proximal end of the catheter. We analysed the pixel-matched phase change between two different frames to yield the radial strain. Imaging experiments were carried out in a phantom and in human coronary arteries in vitro. At an imaging speed of 3019 frames/s, we were able to capture the dynamic strain. Stiff inclusions in the phantom and calcification in atherosclerotic plaques are associated with low strain values and can be distinguished from the surrounding soft material, which exhibits elevated strain. For the first time, circumferential intravascular OCE images are provided side by side with conventional OCT images, simultaneously mapping both the tissue structure and stiffness. |
Özüm Emre
Aşırım,
Robert
Huber, and
Christian
Jirauschek,
Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers, in 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD) , 2022. pp. 67-68.
Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers, in 2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD) , 2022. pp. 67-68.
DOI: | 10.1109/NUSOD54938.2022.9894816 |
Bibtex: | ![]() @INPROCEEDINGS{9894816, author={Aşırım, Ö. E. and Huber, R. and Jirauschek, C.}, booktitle={2022 International Conference on Numerical Simulation of Optoelectronic Devices (NUSOD)}, title={Effect of Self-Phase Modulation on The Signal Quality of Fourier Domain Mode-Locked Lasers}, year={2022}, volume={}, number={}, pages={67-68}, doi={10.1109/NUSOD54938.2022.9894816}} |
P
Musial,
Tabea
Kohlfaerber,
Martin
Ahrens,
Hinnerk
Schulz-Hildebrandt,
Philipp
Steven, and
Gereon
Hüttmann,
Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride, Translational Vision Science & Technology , vol. 11(5), pp. 28-28, 2022.
Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride, Translational Vision Science & Technology , vol. 11(5), pp. 28-28, 2022.
DOI: | 10.1167/tvst.11.5.28 |
Datei: | tvst.11.5.28 |
Bibtex: | ![]() @article{Musial-2022, author = {Musial, G;Kohlfaerber, T;Ahrens, M;Schulz-Hildebrandt, H;Steven, P and Hüttmann, G}, title = {Dynamic Contrast Microscopic Optical Coherence Tomography As a Novel Method for Assessing Corneal Epithelium During Exposure to Benzalkonium Chloride}, journal = {Translational Vision Science & Technology}, keywords = {toxicity; optical coherence tomography; benzalkonium chloride}, volume = {11(5)}, pages = {28-28}, ISSN = {2164-2591}, DOI = {10.1167/tvst.11.5.28}, url = {https://doi.org/10.1167/tvst.11.5.28}, year = {2022}, type = {Journal Article} } |
A. Thambyah
M. Goodwin, and
F.
Vanholsbeeck,
Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography, Osteoarthritis and Cartilage , 2022.
Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography, Osteoarthritis and Cartilage , 2022.
DOI: | https://doi.org/10.1016/j.joca.2022.04.006 |
Bibtex: | ![]() @article{GOODWIN2022, title = {Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography}, journal = {Osteoarthritis and Cartilage}, year = {2022}, issn = {1063-4584}, doi = {https://doi.org/10.1016/j.joca.2022.04.006}, author = {M. Goodwin, M. Klufts, J. Workman, A. Thambyah and F. Vanholsbeeck}, keywords = {Optical coherence tomography, Polarisation-sensitive optical coherence tomography, Osteoarthritis}, abstract = {Summary Objective To explore the ability of polarisation-sensitive optical coherence tomography (PS-OCT) to rapidly identify subtle signs of tissue degeneration in the equine joint. Method Polarisation-sensitive optical coherence tomography (PS-OCT) images were systematically acquired in four locations along the medial and lateral condyles of the third metacarpal bone in five dissected equine specimens. Intensity and retardation PS-OCT images, and anomalies observed therein, were then compared and validated with high resolution images of the tissue sections obtained using Differential Interference contrast (DIC) optical light microscopy. Results The PS-OCT system was capable of imaging the entire equine osteochondral unit, and allowed delineation of the three structurally differentiated zones of the joint, that is, the articular cartilage matrix, zone of calcified cartilage and underlying subchondral bone. Importantly, PS-OCT imaging was able to detect underlying matrix and bone changes not visible without dissection and/or microscopy. Conclusion PS-OCT has substantial potential to detect, non-invasively, sub-surface microstructural changes that are known to be associated with the early stages of joint tissue degeneration.} } |
x-x
Liang,
N.
Linz,
S.
Freidank,
G.
Paltauf, and
A
Vogel,
Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation, Journal of Fluid Mechanics , vol. 940, pp. A5, 2022.
Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation, Journal of Fluid Mechanics , vol. 940, pp. A5, 2022.
DOI: | 10.1017/jfm.2022.202 |
Bibtex: | ![]() @article{Liang2022, author = {Liang, X-X;Linz, N;Freidank, S;Paltauf, G and Vogel, A}, title = {Comprehensive analysis of spherical bubble oscillations and shock wave emission in laser-induced cavitation}, keywords = {bubble dynamics, cavitation, shock waves}, journal = {Journal of Fluid Mechanics}, volume = {940}, pages = {A5}, ISSN = {0022-1120}, DOI = {10.1017/jfm.2022.202}, year = {2022}, type = {Journal Article} } |
Tabea
Kohlfaerber,
Mario
Pieper,
Michael
Münter,
Cornelia
Holzhausen,
Martin
Ahrens,
Christian
Idel,
Ludwig
Bruchhage,
Anke
Leichtle,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways, Biomedical Optics Express , vol. 13 (6), pp. 3211-3223, 2022.
Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways, Biomedical Optics Express , vol. 13 (6), pp. 3211-3223, 2022.
DOI: | 10.1364/BOE.456104 |
Bibtex: | ![]() @article{Kohlfarber2022, author = {Kohlfaerber, T;Pieper, M;Münter, M;Holzhausen, C;Ahrens, M;Idel, C;Bruchhage, K-L;Leichtle, A;König, P;Hüttmann, G and Schulz-Hildebrandt, H}, title = {Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways}, journal = {Biomedical Optics Express}, volume = {13 (6)}, pages = {3211-3223}, DOI = {10.1364/BOE.456104}, year = {2022}, type = {Journal Article} } |
2021
Madita
Göb,
Sazgar
Burhan,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dez.2021. pp. EW3C.4.
Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm2/sec, in European Conferences on Biomedical Optics 2021 (ECBO) , Optical Society of America, Dez.2021. pp. EW3C.4.
DOI: | 10.1117/12.2616054 |
Bibtex: | ![]() @inproceedings{Gob:21, author = {Madita G\"{o}b and Sazgar Burhan and Wolfgang Draxinger and Jan Philip Kolb and Robert Huber}, booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT;Fourier domain mode locking; Image processing; Image quality; Optical coherence tomography; Temporal resolution; Three dimensional imaging}, pages = {EW3C.4}, publisher = {Optical Society of America}, title = {Towards densely sampled ultra-large area multi-MHz-OCT for in vivo skin measurements beyond 1 cm$^2$/sec}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-EW3C.4}, abstract = {We demonstrate a 3.3 MHz A-scan rate OCT for rapid scanning of large areas of human skin. The mosaicking performance and different OCT imaging modalities including intervolume speckle contrast are evaluated.}, } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
Comparison of two optical coherence tomography systems to identify human brain tumor, Optical Society of America, Dez.2021. pp. EW1C.7.
DOI: | 10.1117/12.2616044 |
Bibtex: | ![]() @inproceedings{Strenge:21, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT; Absorption coefficient; Attenuation coefficient; Fourier domain mode locking; Multiple scattering; Optical coherence tomography; Spectral domain optical coherence tomography}, pages = {EW1C.7}, publisher = {Optical Society of America}, title = {Comparison of two optical coherence tomography systems to identify human brain tumor}, year = {2021}, url = {https://doi.org/10.1117/12.2616044}, abstract = {The identification of ex vivo brain tumor tissue was investigated with two different optical coherence tomography systems exploiting two optical parameters. The optical parameters were calculated from semantically labelled OCT B-scans.}, } |
Nicolas
Detrez,
Katharina
Rewerts,
Moritz
Matthiae,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography, in ECBO , Optical Society of America, Dez.2021. pp. EW4A.10.
Weblink: | https://opg.optica.org/abstract.cfm?uri=ECBO-2021-EW4A.10 |
Bibtex: | ![]() @inproceedings{Detrez:21, author = {N. Detrez, K. Rewerts, M. Matthiae, S. Buschschlueter, M.M. Bonsanto, D. Theisen-Kunde and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {EW4A.10}, publisher = {Optical Society of America}, title = {Flow Controlled Air Puff Generator Towards In Situ Brain Tumor Detection Based on MHz Optical Coherence Elastography}, year = {2021}, url = {https://doi.org/10.1117/12.2615022}, abstract = {A precision air puff excitation system for MHz Optical Coherence Elastography in neurosurgery was developed. It enables non-contact soft-tissue excitation down to {\textmu}N, with direct, noncontact force determination via gas flow measurement.}, } |
Katharina
Rewerts,
Moritz
Matthiae,
Nicolas
Detrez,
Steffen
Buschschlüter,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation, in ECBO , Optical Society of America, Dez.2021. pp. ETh3A.3.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETh3A.3 |
Bibtex: | ![]() @inproceedings{Rewerts2021ECBO, author = {K. Rewerts, M. Matthiae, N. Detrez, S. Buschschlueter, M.M. Bonsanto, R. Huber and R. Brinkmann}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {AG-Huber_OCT}, pages = {ETh3A.3}, publisher = {Optical Society of America}, title = {Phase-Sensitive Optical Coherence Elastography with a 3.2 MHz FDML-Laser Using Focused Air-Puff Tissue Indentation}, year = {2021}, url = {http://www.osapublishing.org/abstract.cfm?URI=ECBO-2021-ETh3A.3}, abstract = {Tumor discrimination from healthy tissue is often performed by haptically probing tissue elasticity. We demonstrate non-contact elastography using air-puff excitation and tissue indentation measurement by phase-sensitive OCT with a 3.2 MHz FDML-laser.}, } |
Clara
Pfäffle,
Hendrik
Spahr,
Katharina
Gercke,
Sazan
Burhan,
David
Melenberg,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer, in SPIE BIOS , SPIE, 082021.
DOI: | 10.1117/12.2577605 |
Bibtex: | ![]() @inproceedings{RN5321, author = {Pfäffle, C;Spahr, H;Gercke, K;Burhan, S;Melenberg, D;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Phase-sensitive measurements of depth dependent signal transduction in the inner plexiform layer}, booktitle = {SPIE BiOS}, publisher = {SPIE}, volume = {11623}, url = {https://doi.org/10.1117/12.2577605}, type = {Conference Proceedings} } |
Philipp
Gruening,
Falk
Nette,
Noah
Heldt,
Ana Cristina Guerra
Souza, and
Erhardt
Barth,
Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning, in Proceedings of the Fourth Conference on Medical Imaging with Deep Learning , Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris, Eds. PMLR, 072021. pp. 219--227.
Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning, in Proceedings of the Fourth Conference on Medical Imaging with Deep Learning , Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris, Eds. PMLR, 072021. pp. 219--227.
Weblink: | https://proceedings.mlr.press/v143/gruening21a.html |
Datei: | gruening21a.html |
Bibtex: | ![]() @InProceedings{pmlr-v143-gruening21a, title = {Direct Inference of Cell Positions using Lens-Free Microscopy and Deep Learning}, author = {Gruening, Philipp and Nette, Falk and Heldt, Noah and de Souza, Ana Cristina Guerra and Barth, Erhardt}, booktitle = {Proceedings of the Fourth Conference on Medical Imaging with Deep Learning}, pages = {219--227}, year = {2021}, editor = {Heinrich, Mattias and Dou, Qi and de Bruijne, Marleen and Lellmann, Jan and Schläfer, Alexander and Ernst, Floris}, volume = {143}, series = {Proceedings of Machine Learning Research}, month = {07--09 Jul}, publisher = {PMLR}, pdf = {https://proceedings.mlr.press/v143/gruening21a/gruening21a.pdf}, url = {https://proceedings.mlr.press/v143/gruening21a.html}, abstract = {With in-line holography, it is possible to record biological cells over time in a three-dimensional hydrogel without the need for staining, providing the capability of observing cell behavior in a minimally invasive manner. However, this setup currently requires computationally intensive image-reconstruction algorithms to determine the required cell statistics. In this work, we directly extract cell positions from the holographic data by using deep neural networks and thus avoid several reconstruction steps. We show that our method is capable of substantially decreasing the time needed to extract information from the raw data without loss in quality.} } |
Hubertus
Hakert,
Matthias
Eibl,
Marie
Tillich,
Ralph
Pries,
Gereon
Hüttmann,
Ralf
Brinkmann,
Barbara
Wollenberg,
Ludwig
Bruchhage,
Sebastian
Karpf, and
Robert
Huber,
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1, Optics Letters , vol. 46(14), no. 14, pp. 3456-3459, 07 2021.
DOI: | 10.1364/OL.424726 |
Bibtex: | ![]() @article{Hakert2021, author = {H. Hakert, M. Eibl, M. Tillich, R.Pries, G. Hüttmann, R. Brinkmann, B. Wollenberg, K-L. Bruchhage, S. Karpf and R. Huber}, title = {Time-encoded stimulated Raman scattering microscopy of tumorous human pharynx tissue in the fingerprint region from 1500–1800 cm-1}, journal = {Optics Letters}, volume = {46(14)}, number = {14}, pages = {3456-3459}, keywords = {AG-Huber_NL, Clinical applications, Master oscillator power amplifiers, Optical coherence tomography, Raman scattering, Stimulated Raman scattering, Stimulated scattering}, DOI = {https://doi.org/10.1364/OL.424726}, year = {2021}, type = {Journal Article} } |
Tuula
Peñate Medina,
Jan Philip
Kolb,
Gereon
Hüttmann,
Robert
Huber,
Oula
Peñate Medina,
Naomi
Larsen,
Arianna
Ferrari,
Magdalena
Rafecas,
Mark
Ellrichmann,
Mariya S.
Pravdivtseva,
Mariia
Anikeeva,
Jana
Humbert,
Marcus
Both,
Jennifer
Hundt, and
Jan-Bernd
Hövener,
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
Imaging Inflammation - From Whole Body Imaging to Cellular Resolution, Frontiers in immunology , vol. 12, pp. 692222-692222, 06 2021.
DOI: | 10.3389/fimmu.2021.692222 |
Bibtex: | ![]() @article{PenateMedina2021, author = {Peñate Medina, T;Kolb, J P;Hüttmann, G;Huber, R;Peñate Medina, O;Ha, L;Ulloa, P;Larsen, N;Ferrari, A;Rafecas, M;Ellrichmann, M;Pravdivtseva, M S.;Anikeeva, M;Humbert, J;Both, M;Hundt, J E. and Hövener, J-B}, title = {Imaging Inflammation - From Whole Body Imaging to Cellular Resolution}, journal = {Frontiers in immunology}, keywords = {AG-Huber, MRI, PET, SPECT, optical imaging, Optical coherence tomography (OCT), precision medicine, Two-Photon microscopy (TPM), hyperpolarization}, volume = {12}, pages = {692222-692222}, ISSN = {1664-3224}, DOI = {10.3389/fimmu.2021.692222}, url = {https://pubmed.ncbi.nlm.nih.gov/34248987 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8264453/}, year = {2021}, type = {Journal Article} } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Mark
Schmidt,
Wolfgang
Draxinger,
Jan Philip
Kolb,
Christian
Jirauschek, and
Robert
Huber,
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
Superposition of two independent FDML lasers, in 2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 062021. pp. 1-1.
DOI: | 10.1109/CLEO/Europe-EQEC52157.2021.9542126 |
Bibtex: | ![]() @INPROCEEDINGS{9542126, author={Grill, Christin and Lotz, Simon and Blömker, Torben and Schmidt, Mark and Draxinger, Wolfgang and Kolb, Jan Philip and Jirauschek, Christian and Huber, Robert}, booktitle={2021 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Superposition of two independent FDML lasers}, year={2021}, volume={}, number={}, pages={1-1}, abstract={Fourier domain mode locking (FDML) is a laser operating regime, which was developed in 2005 [1] . The output of this laser is a train of optical wavelength sweeps, equivalent to extremely chirped pulses with an optical bandwidth of up to 25 THz and frequency tuning rates of >10 19 Hz/s. This laser type was developed for optical coherence tomography [2] , but found recently more and more applications like LiDAR [3] , Raman microscopy [4] or two-photon microscopy [5] . The laser’s coherence properties are relevant for a better understanding of the FDML laser itself and its applications. Because of the wide sweep range and high tuning rate, the laser linewidth cannot be measured with an RF spectrometer. Superposition with a narrowband continuous wave laser only yields phase information for small fractions of the sweep [6] . However, beat signal measurements between two independent FDML lasers with equal sweep range and direction can give information about the complete sweep.}, keywords={}, doi={10.1109/CLEO/Europe-EQEC52157.2021.9542126}, ISSN={}, month={June} } |
Tom
Pfeiffer,
Thomas
Klein,
Alexander
Mlynek,
Wolfgang
Wieser,
Simon
Lotz,
Christin
Grill, and
Robert
Huber,
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 062021.
DOI: | 10.1117/12.2583501 |
Bibtex: | ![]() @inproceedings{Pfeiffer2021, author = {T. Pfeiffer, T. Klein, A. Mlynek, W. Wieser, S. Lotz, C. Grill and R. Huber}, title = {{High finesse tunable Fabry-Perot filters in Fourier-domain modelocked lasers}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {We demonstrate that the coherence roll-off and dynamic range of OCT systems using Fourier-domain mode-locked (FDML) lasers can be significantly improved by a fiber Fabry-Perot tunable filter (FFP-TF) with a finesse of more than 3000, a more than fivefold improvement over previous designs. In contrast to previous work, standard resampling using a pre-acquired signal (as in SD-OCT) with no k-clocking is sufficient for 20 nm and 100 nm sweep range, significantly reducing the system complexity. 3D-OCT imaging at 20 cm imaging range is demonstrated.}, keywords = {AG-Huber_FDML, AG-Huber_OCT, optical coherence tomography, FDML laser, swept source laser, high finesse, Fabry-Perot, MHz-OCT, OCT, tunable laser}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2583501} } |
Thomas
Gottschall,
Tobias
Meyer-Zedler,
Michael
Schmitt,
Robert
Huber,
Jürgen
Popp,
Andreas
Tünnermann, and
Jens
Limpert,
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging, JRS , 06 2021.
DOI: | 10.1002/jrs.6171 |
Bibtex: | ![]() @article{Gottschall2021, author = {T. Gottschall, T. Meyer-Zedler, M. Schmitt, R. Huber, J. Popp, A. Tünnermann and J. Limpert}, title = {Ultra-compact tunable fiber laser for coherent anti-Stokes Raman imaging}, journal = {JRS}, keywords = { AG-Huber_NL, coherent anti-Stokes Raman scattering microscopy, four-wave mixing, nonlinear microscopy, ultrafast laser}, ISSN = {0377-0486}, url = {https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/abs/10.1002/jrs.6171}, year = {2021}, type = {Journal Article} } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision, Biomedical Optics Express , vol. 12(5), pp. 2604-2616, 03 2021.
DOI: | 10.1364/BOE.422898 |
Bibtex: | ![]() @article{Lotz2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J.P. Kolb and R. Huber}, title = {Cavity length control for Fourier domain mode locked (FDML) lasers with µm precision}, journal = {Biomedical Optics Express}, volume = {12(5)}, keywords={AG-Huber_FDML}, pages = {2604-2616}, url = {https://doi.org/10.1364/BOE.422898}, year = {2021}, type = {Journal Article} } |
Matthias
Strauch,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Ann-Kathrin
Popp,
Melanie
Wacker,
Nadine
Merg,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
Sectioning-free virtual H&E histology with fiber-based two-photon microscopy, in SPIE BiOS , SPIE, 032021.
DOI: | 10.1117/12.2578334 |
Bibtex: | ![]() @inproceedings{RN5318, author = {Strauch, M;Kolb, J P;Draxinger, W;Popp, A-K;Wacker, M;Merg, N;Hundt, J;Karpf, S and Huber, R}, title = {Sectioning-free virtual H&E histology with fiber-based two-photon microscopy}, booktitle = {SPIE BiOS}, publisher = {SPIE}, volume = {11648}, Year = {2021}, DOI = {https://doi.org/10.1117/12.2578334}, url = {https://doi.org/10.1117/12.2578334}, type = {Conference Proceedings} } |
Paul
Strenge,
Birgit
Lange,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
Characterization of brain tumor tissue with 1310 nm optical coherence tomography, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A. Izatt and James G. Fujimoto, Eds. SPIE, 032021. pp. 74 -- 80.
DOI: | 10.1117/12.2578409 |
Bibtex: | ![]() @inproceedings{Strenge2021A, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, M. Bonsanto, C. Hagel, R. Huber and R. Brinkmann}, title = {{Characterization of brain tumor tissue with 1310 nm optical coherence tomography}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {74 -- 80}, abstract = {The separation of tumorous brain tissue and healthy brain tissue is still a big challenge in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. On the basis of a recently created labelled OCT dataset of ex vivo glioblastoma multiforme tumor samples the detection of brain tumor tissue and the identification of zones with varying degrees of infiltration of tumor cells was investigated. The identification was based on the optical properties, which were extracted by an exponential fit function. The results showed that a separation of tumorous tissue and healthy white matter based on these optical properties is possible. A support vector machine was trained on the optical properties to separate tumor from healthy white matter tissue, which achieved a sensitivity of 91% and a specificity of 76% on an independent training dataset.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578409} } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Veit
Danicke,
Dirk
Theisen-Kunde,
Heinz
Handels,
Christian
Hagel,
Matteo M.
Bonsanto,
Robert
Huber, and
Ralf
Brinkmann,
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , SPIE, 032021. pp. 66 -- 73.
DOI: | 10.1117/12.2578391 |
Bibtex: | ![]() @inproceedings{Strenge2021, author = {P. Strenge, B. Lange, C. Grill, W. Draxinger, V. Danicke, D. Theisen-Kunde, H. Handels, C. Hagel, M. Bonsanto, R. Huber and R. Brinkmann}, title = {{Creating a depth-resolved OCT-dataset for supervised classification based on ex vivo human brain samples}}, volume = {11630}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {66 -- 73}, abstract = {Optical coherence tomography (OCT) has the potential to become an additional imaging modality for surgical guidance in the field of neurosurgery, especially when it comes to the detection of different infiltration grades of glioblastoma multiforme at the tumor border. Interpretation of the images, however, is still a big challenge. A method to create a labeled OCT dataset based on ex vivo brain samples is introduced. The tissue samples were embedded in an agarose mold giving them a distinctive shape before images were acquired with two OCT systems (spectral domain (SD) and swept source (SS) OCT) and histological sections were created and segmented by a neuropathologist. Based on the given shape, the corresponding OCT images for each histological image can be determined. The transfer of the labels from the histological images onto the OCT images was done with a non-affine image registration approach based on the tissue shape. It was demonstrated that finding OCT images of a tissue sample corresponding to segmented histological images without any color or laser marking is possible. It was also shown that the set labels can be transferred onto OCT images. The accuracy of method is 26 ± 11 pixel, which translates to 192 ± 75 μm for the SS-OCT and 94 ± 43 μm for the SD-OCT. The dataset consists of several hundred labeled OCT images, which can be used to train a classification algorithm.}, keywords = {AG-Huber_OCT, optical coherence tomography, OCT, image registration, glioblastoma multiforme, MHz-OCT, brain imaging, tumor, neurosurgery}, year = {2021}, URL = {https://doi.org/10.1117/12.2578391} } |
Philipp
Lamminger,
Merle
Loop,
Julian
Klee,
Daniel
Weng,
Jan Philip
Kolb,
Matthias
Strauch,
Sebastian
Karpf, and
Robert
Huber,
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups, in Multimodal Biomedical Imaging XVI , SPIE, 032021.
DOI: | 10.1117/12.2578679 |
Bibtex: | ![]() @Conference{Lamminger2021, author = {P. Lamminger, M. Loop, J. Klee, D. Weng, J.P. Kolb, M. Strauch, S. Karpf and R. Huber}, booktitle = {Multimodal Biomedical Imaging XVI}, title = {Combination of two-photon microscopy and optical coherence tomography with fully fiber-based lasers for future endoscopic setups}, year = {2021}, publisher = {SPIE}, doi = {10.1117/12.2578679}, keywords = {AG-Huber_NL, AG-Huber_OCT}, } |
Christin
Grill,
Torben
Blömker,
Mark
Schmidt,
Dominic
Kastner,
Tom
Pfeiffer,
Jan Philip
Kolb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Christian
Jirauschek, and
Robert
Huber,
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 032021. pp. 242 -- 247.
DOI: | 10.1117/12.2578293 |
Bibtex: | ![]() @inproceedings{Grill2021, author = {C. Grill, T. Blömker, M. Schmidt, D. Kastner, T. Pfeiffer, J.P. Kolb, W. Draxinger, S. Karpf, C. Jirauschek and R. Huber}, title = {{A detailed analysis of the coherence and field properties of an FDML laser by time resolved beat signal measurements}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {242 -- 247}, keywords = {AG-Huber_FDML, Fourier domain mode locking, FDML laser, laser beating , tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578293} } |
Mark
Schmidt,
Christin
Grill,
Simon
Lotz,
Tom
Pfeiffer,
Robert
Huber, and
Christian
Jirauschek,
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime, Applied Physics B , vol. 127, no. 5, pp. 60, 02 2021.
DOI: | 10.1007/s00340-021-07600-1 |
Bibtex: | ![]() @Article{Schmidt2021, author = {M. Schmidt, C. Grill, S. Lotz, T. Pfeiffer, R. Hubert and C. Jirauschek}, journal = {Applied Physics B}, title = {Intensity pattern types in broadband Fourier domain mode-locked (FDML) lasers operating beyond the ultra-stable regime}, year = {2021}, issn = {1432-0649}, number = {5}, pages = {60}, volume = {127}, keywords={AG-Huber_FDML}, abstract = {We report on the formation of various intensity pattern types in detuned Fourier domain mode-locked (FDML) lasers and identify the corresponding operating conditions. Such patterns are a result of the complex laser dynamics and serve as an ideal tool for the study of the underlying physical processes as well as for model verification. By numerical simulation we deduce that the formation of patterns is related to the spectral position of the instantaneous laser lineshape with respect to the transmission window of the swept bandpass filter. The spectral properties of the lineshape are determined by a long-term accumulation of phase-offsets, resulting in rapid high-amplitude intensity fluctuations in the time domain due to the narrow intra-cavity bandpass filter and the fast response time of the semiconductor optical amplifier gain medium. Furthermore, we present the distribution of the duration of dips in the intensity trace by running the laser in the regime in which dominantly dips form, and give insight into their evolution over a large number of roundtrips.}, doi = {10.1007/s00340-021-07600-1}, refid = {Schmidt2021}, } |
Dirk
Theisen-Kunde,
Wolfgang
Draxinger,
Matteo M.
Bonsanto,
Paul
Strenge,
Nicolas
Detrez,
Robert
Huber, and
Ralf
Brinkmann,
1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery, in European Conferences on Biomedical Optics 2021 (ECBO) , Optica Publishing Group, 2021. pp. ETu4A.2.
1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery, in European Conferences on Biomedical Optics 2021 (ECBO) , Optica Publishing Group, 2021. pp. ETu4A.2.
Weblink: | https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2 |
Datei: | abstract.cfm |
Bibtex: | ![]() @inproceedings{Theisen-Kunde:21, author = {D. Theisen-Kunde and W. Draxinger and M. M. Bonsanto and Paul Strenge and Nicolas Detrez and R. Huber and R. Brinkmann}, booktitle = {European Conferences on Biomedical Optics 2021 (ECBO)}, journal = {European Conferences on Biomedical Optics 2021 (ECBO)}, keywords = {Clinical applications; Fourier domain mode locking; Optical coherence tomography; Optical fibers; Three dimensional reconstruction; White light}, pages = {ETu4A.2}, publisher = {Optica Publishing Group}, title = {1.6 MHz FDML OCT for Intraoperative Imaging in Neurosurgery}, year = {2021}, url = {https://opg.optica.org/abstract.cfm?URI=ECBO-2021-ETu4A.2}, doi = {10.1364/ECBO.2021.ETu4A.2}, abstract = {A 1.6 MHz Fourier-domain mode-locked (FDML) optical coherence tomography (OCT) was adapted to an OR-Microscope for clinical application in neurosurgery. 3D-volume scans at video rate are envisaged with approximately 50{\textmu}m lateral and 20{\textmu}m axial resolution.}, } |
A.
Coker,
V. V.
Yakovlev, and
A .
Vogel,
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions, Photonics Research , vol. 9 (3), pp. 416-423, 2021.
DOI: | 10.1364/PRJ.411980 |
Bibtex: | ![]() @article{Coker2021, author = {Coker, Z. N.;Liang, Xiao-Xuan;Kiester, A. S.;Noojin, G. D.;Bixler, J. N.;Ibey, B. L.;Vogel, A. and Yakovlev, V. V.}, title = {Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions}, journal = {Photonics Research}, volume = {9 (3)}, pages = {416-423}, DOI = {10.1364/PRJ.411980}, year = {2021}, type = {Journal Article} } |
Martin
Ahrens,
Christian
Idel,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI: | 10.1117/12.2578787 |
Datei: | 12.2578787 |
Bibtex: | ![]() @inproceedings{10.1117/12.2578787, title = {Voice coil based endomicroscopic optical coherence tomography probe for in vivo mucosa examination}, author = {Martin Ahrens and Christian Idel and Peter K\"{o}nig and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt}, editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter}, url = {https://doi.org/10.1117/12.2578787}, doi = {10.1117/12.2578787}, year = {2021}, date = {2021-01-01}, booktitle = {Endoscopic Microscopy XVI}, volume = {11620}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Mario
Mordmüller,
Ralf
Brinkmann,
Karl
Worthmann, and
Matthias A.
Müller,
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
State and parameter estimation for model-based retinal laser treatment, IFAC-PapersOnLine , vol. 54(6), pp. 244-250, 2021.
DOI: | https://doi.org/10.1016/j.ifacol.2021.08.552 |
Datei: | S2405896321013276 |
Bibtex: | ![]() @article{Kleyman2021, author = {Kleyman, V;Schaller, M;Wilson, M;Mordmüller, M;Brinkmann, R;Worthmann, K and Müller, M.A.}, title = {State and parameter estimation for model-based retinal laser treatment⁎⁎The collaborative project ”Temperature controlled retinal laser treatment” is funded by the German Research Foundation (DFG) under the project number 430154635 (MU 3929/3-1, WO 2056/7-1, BR 1349/6-1). MS was also funded by the DFG (grant WO 2056/2-1, project number 289034702). KW gratefully acknowledges funding by the German Research Foundation (DFG; grant WO 2056/6-1, project number 406141926)}, journal = {IFAC-PapersOnLine}, volume = {54(6)}, pages = {244-250}, ISSN = {2405-8963}, DOI = {https://doi.org/10.1016/j.ifacol.2021.08.552}, url = {https://www.sciencedirect.com/science/article/pii/S2405896321013276}, year = {2021}, type = {Journal Article} } |
R
Schenk,
S
Kassumeh, and
Reginald
Birngruber,
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography, Tvst , vol. 10 (13), pp. 22-22, 2021.
DOI: | 10.1167/tvst.10.13.22 |
Bibtex: | ![]() @article{Schenk-2021, author = {Schenk, M S;Wartak, A;Buehler, V;Zhao, J;Tearney, G J;Birngruber, R and Kassumeh, S}, title = {Advances in Imaging of Subbasal Corneal Nerves With Micro–Optical Coherence Tomography}, journal = {Tvst}, keywords = {corneal nerves; micro–optical coherence tomography; subbasal plexus}, volume = {10 (13)}, pages = {22-22}, ISSN = {2164-2591}, DOI = {10.1167/tvst.10.13.22}, year = {2021}, type = {Journal Article} } |
Aaron Doug Deen,
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
Spectroscopic analysis through thermoelastic optical coherence microscopy, in European Conferences on Biomedical Optics , SPIE, 2021.
Datei: | 12.2616068 |
Bibtex: | ![]() @inproceedings{Deen2021, author = {Doug Deen, A;Pfeiffer, T;van Beusekom, H;Essers, J;van der Steen, A F.;Huber, Rt;van Soest, G and Wang, T}, title = {Spectroscopic analysis through thermoelastic optical coherence microscopy}, booktitle = {European Conferences on Biomedical Optics}, publisher = {SPIE}, year = {2021}, volume = {11924}, url = {https://doi.org/10.1117/12.2616068}, type = {Conference Proceedings} } |
Mario Mordmüller,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: | 12.2615851 |
Bibtex: | ![]() @inproceedings{Mordmüller2021, author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R}, title = { Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2615851}, year = {2021}, type = {Conference Proceedings} } |
Elisabeth
Richert,
Julia
Papenkort,
Claus
von der Burchard,
Alexa
Klettner,
Patrik
Arnold,
Ralph
Lucius,
Ralf
Brinkmann,
Carsten
Framme,
Johann
Roider, and
Jan
Tode,
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy, BMC Ophthalmology , vol. 21(1), pp. 412, 2021.
Datei: | s12886-021-02188-8 |
Bibtex: | ![]() @article{Richert2021, title = {Selective retina therapy and thermal stimulation of the retina: different regenerative properties - implications for AMD therapy}, author = {Richert, E;Papenkort, J;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Framme, C;Roider, J and Tode, J}, year = 2021, journal = {BMC Ophthalmology}, volume = {21(1)}, pages = 412, issn = {1471-2415}, url = {https://doi.org/10.1186/s12886-021-02188-8}, keywords = {Selective retina therapy (SRT), Thermal stimulation of the retina (TSR), Age- related macular degeneration (AMD), Regeneration, Rejuvenation}, type = {Journal Article} } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser, in ECBO , 2021.
Datei: | 12.2615851 |
Bibtex: | ![]() @inproceedings{Mordmüller2021, author = {Mordmüller, M;Kleymann, V;Schaller, M;Wilson, M;Wothmann, K;Müller, M A and Brinkman, R}, title = { Towards Model-based Control Techniques for Retinal Laser Treatment Using Only One Laser}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2615851}, year = {2021}, type = {Conference Proceedings} } |
Mario
Mordmüller,
Viktoria
Kleymann,
Manuel A.
Schaller,
Mitsuru
Wilson,
Dirk
Theisen-Kunde,
Karl
Worthmann,
Matthias A.
Müller, and
Ralf
Brinkmann,
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate, Advanced Optical Technologies , 2021.
Datei: | aot-2021-0041 |
Bibtex: | ![]() @article{Mordmüller-2021, author = {Mordmüller, M;Kleyman, V;Schaller, M;Wilson, M;Theisen-Kunde, D;Worthmann, K;Müller, M.A and Brinkmann, R}, title = {Towards temperature controlled retinal laser treatment with a single laser at 10 kHz repetition rate}, journal = {Advanced Optical Technologies}, Keywords = {extended Kalman filter; laser-coagulation; model predictive control; ophthalmology; photo-acoustics}, url = {https://doi.org/10.1515/aot-2021-0041}, year = {2021}, type = {Journal Article} } |
Sonja
Jäckle,
Tim
Eixmann,
Florian
Matysiak,
Malte Maria
Sieren,
Marco
Horn,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann, and
Torben
Pätz,
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair, Current Directions in Biomedical Engineering , vol. 7(1), no. 1, pp. 17--20, 2021.
DOI: | doi:10.1515/cdbme-2021-1004 |
Datei: | cdbme-2021-1004 |
Bibtex: | ![]() @article{Jaeckle2021c, author = {J{\"{a}}ckle, Sonja and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and P{\"{a}}tz, Torben}, doi = {doi:10.1515/cdbme-2021-1004}, journal = {Current Directions in Biomedical Engineering}, year = {2021}, number = {1}, pages = {17--20}, title = {{3D Stent Graft Guidance based on Tracking Systems for Endovascular Aneurysm Repair:}}, url = {https://doi.org/10.1515/cdbme-2021-1004}, volume = {7}, } |
Matthias
Strauch,
Jan Philip
Kolb,
Christian
Rose,
Nadine
Merg,
Jennifer
Hundt,
Christiane
Kümpers,
Sven
Perner,
Sebastian
Karpf, and
Robert
Huber,
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy, in 33rd Congress of the ESP , 2021.
DOI: | 10.1007/s00428-021-03157-8 |
Bibtex: | ![]() @Conference{Strauch2021, author = {M. Strauch, J.P. Kolb, C. Rose, N. Merg, J. Hundt, C. Kümpers, S. Perner, S. Karpf and R. Huber}, booktitle = {33rd Congress of the ESP}, title = {Quick sectioning-free H&E imaging of bulk tissue using multiphoton microscopy}, year = {2021}, keywords = {AG-Huber_NL}, } |
H. S. Seifert,
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
Single pulse optoacoustic temperature measurement, in ECBO , 2021.
DOI: | 10.1117/12.2615897 |
Bibtex: | ![]() @inproceedings{Seifert2021, author = {Seifert, E;Abbas, H. S. and Brinkman, R}, title = {Single pulse optoacoustic temperature measurement}, booktitle = {ECBO}, DOI = {10.1117/12.2615897}, year = {2021}, type = {Conference Proceedings} } |
Maximilian
Büttner,
Benjamin
Luger,
Wasim Abou
Moulig,
Bernd
Junker,
Carsten
Framme,
Christina
Jacobson,
Katharina
Knoll,
Amelie
Pielen,
SRT Study Group-Theisen-Kunde, Brinkmann, Miura,Birngruber,
Ralf
Brinkmann,
Dirk
Theisen-Kunde, and
Yoko
Miura,
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results, Graefes Arch Clin Exp Ophthalmol , vol. 259, no. 6, pp. 1401-1410, 2021.
DOI: | 10.1007/s00417-020-04999-9 |
Bibtex: | ![]() @article{Büttner2021, author = {Büttner, M.;Luger, B.;Abou Moulig, W.;Junker, B.;Framme, C.;Jacobsen, C.;Knoll, K. and Pielen, A.; SRT Study Group(Brinkmann, R.; Miura, Y.)}, title = {Selective retina therapy (SRT) in patients with therapy refractory persistent acute central serous chorioretinopathy (CSC): 3 months functional and morphological results}, journal = {Graefes Arch Clin Exp Ophthalmol}, volume = {259}, number = {6}, pages = {1401-1410}, ISSN = {0721-832X (Print) 0721-832x}, DOI = {10.1007/s00417-020-04999-9}, abstract = { PURPOSE: Central serous chorioretinopathy (CSC) is a disease presenting with detachment of the neurosensory retina and characteristic focal leakage on fluorescein angiography. The spontaneous remission rate is 84% within 6 months. In this study, the efficacy of selective retina therapy (SRT) was examined in patients with therapy refractory persistent acute CSC defined by symptoms for at least 6 months and persistent subretinal fluid (SRF) despite eplerenone therapy. MATERIAL AND METHODS: This is a prospective, monocentric observational study in 17 eyes (16 patients, mean age 42 years, 2 female). SRT was performed with the approved R:GEN laser (Lutronic, South Korea), a micropulsed 527-nm Nd:YLF laser device, with a train of 30 pulses of 1.7 μs at 100-Hz repetition rate at the point of focal leakage determined by fluorescein angiography (FA) at baseline (BSL). Visits on BSL, week 4 (wk4), and week 12 (wk12) included best corrected visual acuity (BCVA, logMar), central retinal thickness (CRT) on spectral domain optical coherence tomography (SD-OCT), and FA. Statistical analysis was performed by pair-by-pair comparisons of multiple observations in each case with Bonferroni correction for multiple testing. (IBM SPSS Statistics 25®). RESULTS: Mean CRT at BSL was 387.69 ± 110.4 μm. CRT significantly decreased by 106.31 μm in wk4 (95%-KI: 21.42-191.2; p = 0.01), by 133.63 μm in wk12 (95%-KI: 50.22-217.03; p = 0.001) and by 133.81 μm (95%-KI: 48.88-218.75; p = 0.001) compared to BSL. Treatment success defined as complete resolution of SRF occurred at wk4 in 7/17 eyes (35.3%) and at wk12 in 10/17 eyes (58.8%). Re-SRT was performed in 7/17 eyes (41.2%) after an average of 107.14 ± 96.59 days. Treatment success after Re-SRT was observed in 4/6 eyes (66.6%, 12 weeks after Re-SRT). Mean BCVA did not change significantly from BSL to any later timepoint after adjusting for multiple testing. Notably, eyes with treatment success showed better BCVA at all timepoints and gained more letters compared to failures. CONCLUSION: Single or repetitive SRT may be an effective and safe treatment in 2 of 3 patients suffering from acute persistent CSC after 6 months of symptoms or more. We observed complete resolution of SRF in around 60% of eyes 12 weeks after first SRT treatment and also 12 weeks after Re-SRT treatment in eyes with persistent or recurrent SRF. Results on the long-term course after SRT are still pending.}, keywords = { Central serous chorioretinopathy; Fluorescein angiography; Micropulse laser; OCT; Persistent acute disease; Selective retina treatment; Subretinal fluid. }, year = {2021}, type = {Journal Article} } |
Felix
Hilge,
Michael
Evers,
Malte
Casper,
Joshua Zev
Glahn,
Weeranut Phothong
M.D.,
Garuna Kositratna
M.D.,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann, and
Dieter Manstein
M.D.,
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography, in Photonics in Dermatology and Plastic Surgery 2021 , Bernard Choi and Haishan Zeng, Eds. SPIE, 2021.
DOI: | 10.1117/12.2577822 |
Datei: | 12.2577822 |
Bibtex: | ![]() @inproceedings{10.1117/12.2577822, title = {Novel method to assess the impact of aging and sun exposure on skin morphology by optical coherence tomography}, author = {Felix Hilge and Michael Evers and Malte Casper and Joshua Zev Glahn and Weeranut Phothong M.D. and Garuna Kositratna M.D. and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Dieter Manstein M.D.}, editor = {Bernard Choi and Haishan Zeng}, url = {https://doi.org/10.1117/12.2577822}, doi = {10.1117/12.2577822}, year = {2021}, date = {2021-01-01}, booktitle = {Photonics in Dermatology and Plastic Surgery 2021}, volume = {11618}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Michel
Wunderlich,
Peter
Koch,
Helge
Sudkamp,
Michael
Münst,
Malte
Endt,
Moritz
Moltmann, and
Gereon
Hüttmann,
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms, in Ophthalmic Technologies XXXI , Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker, Eds. SPIE, 2021. pp. 116231Q.
DOI: | 10.1117/12.2583030 |
Datei: | 12.2583030 |
Bibtex: | ![]() @inproceedings{10.1117/12.2583030, author = {Michel Wunderlich and Peter Koch and Helge Sudkamp and Michael M{\"u}nst and Malte vom Endt and Moritz Moltmann and Gereon H{\"u}ttmann}, title = {{Eye tracking with off-axis full-field OCT by local analysis of recorded interferograms}}, volume = {11623}, booktitle = {Ophthalmic Technologies XXXI}, editor = {Daniel X. Hammer and Karen M. Joos and Daniel V. Palanker}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {116231Q}, keywords = {Retinal motion tracking in Off-Axis Full-Field OCT by local analy, Michel Wunderlich, Medizinsches Laserzentrum Lübeck, motion tracking, eye tracking, off-axis full-field time-domain OCT, OCT, retina}, year = {2021}, doi = {10.1117/12.2583030}, URL = {https://doi.org/10.1117/12.2583030} } |
Michael
Münter,
Mario
Pieper,
Tabea
Kohlfaerber,
Ernst
Bodenstorfer,
Martin
Ahrens,
Christian
Winter,
Robert
Huber,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast, Biomed. Opt. Express , vol. 12, pp. 6024-6039, 2021.
DOI: | 10.1364/BOE.425001 |
Bibtex: | ![]() @article{Münter2021, author = {M. Münter, M. Pieper, T. Kohlfaerber, E. Bodenstorfer, M. Ahrens, C. Winter, R. Huber, P. König, G. Hüttmann and H. Schulz-Hildebrandt}, title = {Microscopic optical coherence tomography (mOCT) at 600 kHz for 4D volumetric imaging and dynamic contrast}, journal = {BiomedOptE}, volume = {12(10)}, Keywords = {CMOS cameras,Full field optical coherence tomography,High numerical aperture optics, Image processing,In vivo imaging,Medical imaging,Ag-Huber}, pages = {6024-6039}, DOI = {10.1364/BOE.425001}, year = {2021}, type = {Journal Article} } |
J. Workman
F. Vanholsbeeck, and
A.
Thambyah,
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography, in Optical Elastography and Tissue Biomechanics VIII , Kirill V. Larin and Giuliano Scarcelli, Eds. SPIE, 2021.
DOI: | 10.1117/12.2587181 |
Bibtex: | ![]() @inproceedings{10.1117/12.2587181, author = {F. Vanholsbeeck, M. Goodwin, M. Klufts, J. Workman and A. Thambyah}, title = {{Birefringence as a proxy for viscoelastic properties of cartilage using polarisation sensitive optical coherence tomography}}, volume = {11645}, booktitle = {Optical Elastography and Tissue Biomechanics VIII}, editor = {Kirill V. Larin and Giuliano Scarcelli}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, abstract = {Non-invasive identification, understanding and evaluation of articular cartilage damage is paramount for osteoarthritis researcher and clinician alike. Using polarisation sensitive optical coherence tomography together with impact and creep load, we use a range of metrics including birefringence to detect early signs of cartilage degeneration and gain new insights into the physiology of joint tissues}, year = {2021}, doi = {10.1117/12.2587181}, } |
Simon
Lotz,
Christin
Grill,
Madita
Göb,
Wolfgang
Draxinger,
Jan Philip
Kolb, and
Robert
Huber,
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
Characterization of the dynamics of an FDML laser during closed-loop cavity length control, in Fiber Lasers XVIII: Technology and Systems , Michalis N. Zervas, Eds. SPIE, 2021. pp. 236 -- 241.
DOI: | 10.1117/12.2578514 |
Bibtex: | ![]() @inproceedings{LotzLASE2021, author = {S. Lotz, C. Grill, M. Göb, W. Draxinger, J. P. Kolb and R. Huber}, title = {{Characterization of the dynamics of an FDML laser during closed-loop cavity length control}}, volume = {11665}, booktitle = {Fiber Lasers XVIII: Technology and Systems}, editor = {Michalis N. Zervas}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {236 -- 241}, abstract = {In Fourier domain mode locked (FDML) lasers, extremely precise and stable matching of the filter tuning period and light circulation time in the cavity is essential for ultra-low noise operation. During the operation of FDML lasers, the ultra-low noise mode can be lost due to temperature drifts of the already temperature stabilized cavity resulting in increased intensity noise. Until now, the filter frequency is continuously regulated to match the changing light circulation time. However, this causes the filter frequency to constantly change by a few mHz and leads to synchronization issues in cases where a fixed filter frequency is desired. We present an actively cavity length controlled FDML laser and a robust and high precision feedback loop algorithm for maintaining ultra-low noise operation. Instead of adapting the filter frequency, the cavity length is adjusted by a motorized free space beam path to match the fixed filter frequency. The closed-loop system achieves a stability of ~0.18 mHz at a sweep repetition rate of ~418 kHz which corresponds to a ratio of 4×10<sup>-10</sup>. We investigate the coherence properties during the active cavity length adjustments and observe no noise increase compared to fixed cavity length. The cavity length control is fully functional and for the first time, offers the possibility to operate an FDML laser in sweet spot mode at a fixed frequency or phase locked to an external clock. This opens new possibilities for system integration of FDML lasers.}, keywords = {AG-Huber_FDML, FDML, Fourier domain mode locking, laser beating, tunable laser, optical coherence tomography, OCT}, year = {2021}, URL = {hhttps://doi.org/10.1117/12.2578514} } |
Matteo Guiseppe
Cereda,
Y.G.M.
Douven,
Koorosh
Faridpooya,
Gereon
Hüttmann,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gernot
Kronreif,
Saskia
van Romunde,
Maarten
Beelen, and
M D.
de Smet,
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery, Ophthalmology Science , vol. 1(4), pp. 100085, 2021.
DOI: | https://doi.org/10.1016/j.xops.2021.100085 |
Bibtex: | ![]() @article{Cereda-2021, author = {Cereda, M G;Parrulli, S;Douven, Y. G. M.;Faridpooya, K;van Romunde, S;Hüttmann, G;Eixmann, T;Schulz-Hildebrandt, H;Kronreif, G;Beelen, M and de Smet, M D.}, title = {Clinical Evaluation of an Instrument-Integrated OCT-Based Distance Sensor for Robotic Vitreoretinal Surgery}, journal = {Ophthalmology Science}, volume = {1(4)}, pages = {100085}, ISSN = {2666-9145}, DOI = {https://doi.org/10.1016/j.xops.2021.100085}, year = {2021}, type = {Journal Article} } |
Tabea
Kohlfaerber,
Mario
Pieper,
Peter
König,
Ramtin
Rahmanzadeh,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV , Joseph A Izatt and James G Fujimoto, Eds. SPIE, 2021.
DOI: | 10.1117/12.2583811 |
Datei: | 12.2583811 |
Bibtex: | ![]() @inproceedings{10.1117/12.2583811, title = {Comparison between dynamic microscopic OCT and autofluorescence multiphoton microscopy for label-free analysis of murine trachea}, author = {Tabea Kohlfaerber and Michael M\"{u}nter and Mario Pieper and Peter K\"{o}nig and Ramtin Rahmanzadeh and Gereon H\"{u}ttmann and Hinnerk Schulz-Hildebrandt}, editor = {Joseph A Izatt and James G Fujimoto}, url = {https://doi.org/10.1117/12.2583811}, doi = {10.1117/12.2583811}, year = {2021}, date = {2021-01-01}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV}, volume = {11630}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Matthias
Strauch,
Jan Philip
Kolb,
Christian
Rose,
Nadine
Merg,
Christiane
Kümpers,
Sven
Perner,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Comparison of Sectioning-free Multiphoton Histology to H&E FFPE imaging, in Virtuelle Pathologietage , 2021.
Eric
Seifert,
Jan
Tode,
Amelie
Pielen,
Dirk
Theisen-Kunde,
Carsten
Framme,
Johann
Roider,
Yoko
Miura,
Reginald
Birngruber, and
Ralf
Brinkmann,
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Algorithms for optoacoustically controlled selective retina therapy (SRT), Photoacoustics , vol. 25, pp. 100316, 2021.
Datei: | S2213597921000756 |
Bibtex: | ![]() @article{Seifert2021, author = {Seifert, E;Tode, J;Pielen, A;Theisen-Kunde, D;Framme, C;Roider, J;Miura, Y;Birngruber, R and Brinkmann, R}, title = {Algorithms for optoacoustically controlled selective retina therapy (SRT)}, journal = {Photoacoustics}, Keywords = {SRT; Lasers in medicine; Ophthalmology; RPE; Selectivity; Algorithm; Retina therapy; Optoacoustics; Feedback}, volume = {25}, pages = {100316}, ISSN = {2213-5979}, url = {https://www.sciencedirect.com/science/article/pii/S2213597921000756}, year = {2021}, type = {Journal Article} } |
Hinnerk
Schulz-Hildebrandt,
Martin
Ahrens,
Elisa
Wilken,
Cornelia
Holzhausen,
Peter
König, and
Gereon
Hüttmann,
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast, in Endoscopic Microscopy XVI , Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter, Eds. SPIE, 2021.
DOI: | 10.1117/12.2575733 |
Datei: | 12.2575733 |
Bibtex: | ![]() @inproceedings{10.1117/12.2575733, title = {Endo-microscopic optical coherence tomography (emOCT) with dynamic contrast}, author = {Hinnerk Schulz-Hildebrandt and Martin Ahrens and Michael M\"{u}nter and Elisa Wilken and Tabea Kohlf\"{a}rber and Cornelia Holzhausen and Peter K\"{o}nig and Gereon H\"{u}ttmann}, editor = {Guillermo Tearney J M.D. and Thomas D Wang and Melissa J Suter}, url = {https://doi.org/10.1117/12.2575733}, doi = {10.1117/12.2575733}, year = {2021}, date = {2021-01-01}, booktitle = {Endoscopic Microscopy XVI}, volume = {11620}, publisher = {SPIE}, organization = {International Society for Optics and Photonics}, keywords = {}, pubstate = {published}, tppubtype = {inproceedings} } |
Christian
Burri,
Alessa
Hutfilz,
Lorenz
Grimm,
Simon
Salzmann,
Patrik
Arnold,
Boris
Považay,
Christoph
Meier,
Andreas
Ebneter,
Dirk
Theisen-Kunde, and
Ralf
Brinkmann,
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery, Applied Sciences , vol. 11(12), pp. 5535, 2021.
DOI: | https://doi.org/10.3390/app11125535 |
Datei: | 5535 |
Bibtex: | ![]() @article{Burri2021, author = {Burri, C;Hutfilz, A;Grimm, L;Salzmann, S;Arnold, P;Považay, B;Meier, C;Ebneter, A;Theisen-Kunde, D and Brinkmann, R}, title = {Dynamic OCT Signal Loss for Determining RPE Radiant Exposure Damage Thresholds in Microsecond Laser Microsurgery}, journal = {Applied Sciences}, volume = {11(12)}, pages = {5535}, ISSN = {2076-3417}, DOI = { https://doi.org/10.3390/app11125535}, url = {https://www.mdpi.com/2076-3417/11/12/5535}, year = {2021}, keywords = {selective retina therapy; viability assay; photocoagulation; microbubble formation; thermomechanical damage; fringe washout; coherence-loss}, type = {Journal Article} } |
Akika
Kyo,
Manabu
Yamamoto,
Kumiko
Hirayama,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Yoko
Miura, and
Shigeru
Honda,
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy, Sci Rep , vol. 11(1), pp. 8973, 2021.
DOI: | 10.1038/s41598-021-88372-8 |
Bibtex: | ![]() @article{Kyo-2021, author = {Kyo, A.;Yamamoto, M.;Hirayama, K.;Kohno, T.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.}, title = {Factors affecting resolution of subretinal fluid after selective retina therapy for central serous chorioretinopathy}, journal = {Sci Rep}, volume = {11(1)}, pages = {8973}, ISSN = {2045-2322}, DOI = {10.1038/s41598-021-88372-8}, year = {2021}, type = {Journal Article} } |
Michelle
Prasuhn,
Yoko
Miura,
Aysegül
Tura,
Felix
Rommel,
Vinodh
Kakkassery,
Svenja
Sonntag,
Salvatore
Grisanti, and
Mahdy
Ranjbar,
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study, J ClinMed , vol. 10(11), pp. 2418, 2021.
DOI: | 10.3390/jcm10112418 |
Datei: | 2418 |
Bibtex: | ![]() @article{Prasuhn2021, author = {Prasuhn, M;Miura, Y;Tura, A.;Rommel, Felix;Kakkassery, V;Sonntag, S;Grisanti, S and Ranjbar, M}, title = {Influence of Retinal Microsecond Pulse Laser Treatment in Central Serous Chorioretinopathy: A Short-Term Optical Coherence Tomography Angiography Study}, journal = {J ClinMed}, volume = {10(11)}, pages = {2418}, ISSN = {2077-0383}, url = {https://www.mdpi.com/2077-0383/10/11/2418}, year = {2021}, type = {Journal Article} } |
M Hutfilz,
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths, in ECBO , Osa, 2021.
Datei: | 12.2614437 |
Bibtex: | ![]() @inproceedings{Hutfilz2021, author = {Hutfilz, A;Theisen-Kunde, D;Bonsanto, M and Brinkman, R}, title = {Laser Coagulation of Brain tissue at 1480 nm and 1940 nm wavelengths}, booktitle = {ECBO}, url = {https://doi.org/10.1117/12.2614437}, publisher = {Osa}, year = {2021}, type = {Conference Proceedings} } |
E.
Seifert,
Kleingarn
Philipp,
Svenja
Sonntag,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Reginald
Birngruber,
Yoko
Miura, and
Ralf
Brinkmann,
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime, Investigative Ophthalmology & Visual Science , vol. 62(3), pp. 32-32, 2021.
DOI: | 10.1167/iovs.62.3.32 |
Datei: | iovs.62.3.32 |
Bibtex: | ![]() @article{Seifert2021, author = {Seifert, E;Sonntag, S R;Kleingarn, P;Theisen-Kunde, D;Grisanti, S;Birngruber, R;Miura, Y and Brinkmann, R}, title = {Investigations on Retinal Pigment Epithelial Damage at Laser Irradiation in the Lower Microsecond Time Regime}, journal = {Investigative Ophthalmology & Visual Science}, volume = {62(3)}, pages = {32-32}, ISSN = {1552-5783}, DOI = {10.1167/iovs.62.3.32}, url = {https://doi.org/10.1167/iovs.62.3.32}, year = {2021}, type = {Journal Article} } |
A S Krumm,
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy, in ECBO , 2021.
DOI: | https://doi.org/10.1117/12.2614447 |
Bibtex: | ![]() @inproceedings{Krumm-2021, author = {Krumm, L S;Lange, B;Ozimek, T;Wießmeyer, J R;Kramer, M W;Merseburger, A S and Brinkman, R}, title = {Fiber-based Fluorescence and Reflection Measurements during Laser Lithotripsy}, Year = {2021}, booktitle = {ECBO}, DOI = {https://doi.org/10.1117/12.2614447}, type = {Conference Proceedings} } |
Sonja
Jäckle,
Annkristin
Lange,
Veronica
Garcia-Vazquez,
Tim
Eixmann,
Florian
Matysiak,
Malte Maria
Sieren,
Marco
Horn,
Gereon
Hüttmann,
Hinnerk
Schulz-Hildebrandt,
Floris
Ernst,
Stefan
Heldmann,
Torben
Pätz, and
Tobias
Preusser,
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging, International Journal of Medical Robotics and Computer Assisted Surgery , vol. 17(6), no. 6, pp. e2327, 2021.
DOI: | 10.1002/rcs.2327 |
Bibtex: | ![]() @article{Jackle2021, abstract = {Background: In endovascular aneuysm repair (EVAR) procedures, medical instruments are currently navigated with a two-dimensional imaging based guidance requiring X-rays and contrast agent. Methods: Novel approaches for obtaining the three-dimensional instrument positions are introduced. Firstly, a method based on fibre optical shape sensing, one electromagnetic sensor and a preoperative computed tomography (CT) scan is described. Secondly, an approach based on image processing using one 2D fluoroscopic image and a preoperative CT scan is introduced. Results: For the tracking based method, average errors from 1.81 to 3.13 mm and maximum errors from 3.21 to 5.46 mm were measured. For the image-based approach, average errors from 3.07 to 6.02 mm and maximum errors from 8.05 to 15.75 mm were measured. Conclusion: The tracking based method is promising for usage in EVAR procedures. For the image-based approach are applications in smaller vessels more suitable, since its errors increase with the vessel diameter.}, author = {J{\"{a}}ckle, Sonja and Lange, Annkristin and Garcia-Vazquez, Veronica and Eixmann, Tim and Matysiak, Florian and Sieren, Malte Maria and Horn, Marco and Schulz-Hildebrandt, Hinnerk and H{\"{u}}ttmann, Gereon and Ernst, Floris and Heldmann, Stefan and P{\"{a}}tz, Torben and Preusser, Tobias}, doi = {10.1002/rcs.2327}, file = {:Users/schulz-hildebrandt/Documents/Mendeley Desktop/J{\"{a}}ckle et al/International Journal of Medical Robotics and Computer Assisted Surgery/J{\"{a}}ckle et al. - 2021 - Instrument localisation for endovascular aneurysm repair Comparison of two methods based on tracking systems or.pdf:pdf}, issn = {1478596X}, journal = {International Journal of Medical Robotics and Computer Assisted Surgery}, keywords = {2D/3D registration,3D localisation,computer-assisted surgery,electromagnetic tracking system,endovascular procedures,fibre optical shape sensing}, number = {6}, pages = {e2327}, year = {2021}, title = {{Instrument localisation for endovascular aneurysm repair: Comparison of two methods based on tracking systems or using imaging}}, volume = {17} } |
B L
Ibey, and
N.
Linz,
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
Front Matter: Volume 11640, in SPIE BiOS , SPIE, 2021.
Datei: | 12.2596605 |
Bibtex: | ![]() @inproceedings{Linz2021, author = {Ibey, B L and Linz, N}, title = {Front Matter: Volume 11640}, booktitle = {SPIE BiOS}, Year = {2021}, publisher = {SPIE}, volume = {11640}, url = {https://doi.org/10.1117/12.2596605}, type = {Conference Proceedings} } |
Yoko Miura,
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO, Nippon Laser Igakkaishi , vol. advpub, 2021.
DOI: | 10.2530/jslsm.jslsm-42_0008 |
Bibtex: | ![]() @article{Miura-3, author = {Miura, Y}, title = {Fluorescence Lifetime Imaging Ophthalmoscopy—FLIO}, journal = {Nippon Laser Igakkaishi}, volume = {advpub}, DOI = {10.2530/jslsm.jslsm-42_0008}, year = {2021}, type = {Journal Article} } |
Svenja
Sonntag,
Eric
Seifert,
Maximilian
Hamann,
Britta
Lewke,
Dirk
Theisen-Kunde,
Salvatore
Grisanti,
Ralf
Brinkmann, and
Yoko
Miura,
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States, Life , vol. 11(6), pp. 555, 2021.
DOI: | https://www.mdpi.com/2075-1729/11/6/555 |
Datei: | 555 |
Bibtex: | ![]() @article{Miura2021-2, author = {Sonntag, S R;Seifert, E;Hamann, M;Lewke, B;Theisen-Kunde, D;Grisanti, S;Brinkmann, R and Miura, Y}, title = {Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States}, journal = {Life}, volume = {11(6)}, keywords = {retinal laser treatment; metabolic change; fluorescence lifetime imaging ophthalmoscopy}, pages = {555}, ISSN = {2075-1729}, url = {https://www.mdpi.com/2075-1729/11/6/555}, year = {2021}, type = {Journal Article} } |
2020
Claus
von der Burchard,
Moritz
Moltmann,
Jan
Tode,
Christoph
Ehlken,
Helge
Sudkamp,
Dirk
Theisen-Kunde,
Inke R.
König,
Gereon
Hüttmann, and
Johann
Roider,
Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases, Graefe's Archive for Clinical and Experimental Ophthalmology , Dez. 2020.
Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases, Graefe's Archive for Clinical and Experimental Ophthalmology , Dez. 2020.
Datei: | s00417-020-05035-6 |
Bibtex: | ![]() @article{von-derBurchard2020, author = {von der Burchard, C;Moltmann, M.;Tode, J;Ehlken, C;Sudkamp, H;Theisen-Kunde, D;König, I;Hüttmann, G and Roider, J}, title = {Self-examination low-cost full-field OCT (SELFF-OCT) for patients with various macular diseases}, journal = {Graefe's Archive for Clinical and Experimental Ophthalmology}, ISSN = {1435-702X}, url = {https://doi.org/10.1007/s00417-020-05035-6}, year = {2020}, type = {Journal Article} } |
Mark
Schmidt,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime, in 2020 International Conference Laser Optics (ICLO) , Nov.2020. pp. 1-1.
Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime, in 2020 International Conference Laser Optics (ICLO) , Nov.2020. pp. 1-1.
DOI: | 10.1109/ICLO48556.2020.9285488 |
Bibtex: | ![]() @INPROCEEDINGS{Schmidt2020ICLO, author={M. {Schmidt}, C. {Grill}, R. {Huber} and C. {Jirauschek}}, booktitle={2020 International Conference Laser Optics (ICLO)}, title={Coherence of Fourier Domain Mode-Locked (FDML) Lasers in the Ultra-Stable Regime}, year={2020}, keywords={AG-Huber_FDML}, volume={}, number={}, pages={1-1}, doi={10.1109/ICLO48556.2020.9285488}, } |
Tom
Pfeiffer,
Madita
Göb,
Wolfgang
Draxinger,
Sebastian
Karpf,
Jan Philip
Kolb, and
Robert
Huber,
Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging, Biomed. Opt. Express , vol. 11, no. 11, pp. 6799--6811, Nov. 2020. OSA.
Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging, Biomed. Opt. Express , vol. 11, no. 11, pp. 6799--6811, Nov. 2020. OSA.
DOI: | 10.1364/BOE.402477 |
Bibtex: | ![]() @article{Pfeiffer:20, author = {T. Pfeiffer, M. G\"{o}b, W. Draxinger, S. Karpf, J.P. Kolb and R. Huber}, journal = {Biomed. Opt. Express}, keywords = {AG-Huber_OCT; High speed imaging; Image quality; Optical coherence tomography; Swept lasers; Swept sources; Systems design}, number = {11}, pages = {6799--6811}, publisher = {OSA}, title = {Flexible A-scan rate MHz-OCT: efficient computational downscaling by coherent averaging}, volume = {11}, month = {Nov}, year = {2020}, doi = {10.1364/BOE.402477}, abstract = {In order to realize adjustable A-scan rates of fast optical coherence tomography (OCT) systems, we investigate averaging of OCT image data acquired with a MHz-OCT system based on a Fourier Domain Mode Locked (FDML) laser. Increased system sensitivity and image quality can be achieved with the same system at the cost of lower imaging speed. Effectively, the A-scan rate can be reduced in software by a freely selectable factor. We demonstrate a detailed technical layout of the strategies necessary to achieve efficient coherent averaging. Since there are many new challenges specific to coherent averaging in swept source MHz-OCT, we analyze them point by point and describe the appropriate solutions. We prove that coherent averaging is possible at MHz OCT-speed without special interferometer designs or digital phase stabilization. We find, that in our system up to \&\#x223C;100x coherent averaging is possible while achieving a sensitivity increase close to the ideal values. This corresponds to a speed reduction from 3.3 MHz to 33 kHz and a sensitivity gain of 20 dB. We show an imaging comparison between coherent and magnitude averaging of a human finger knuckle joint in vivo with 121\&\#x00A0;dB sensitivity for the coherent case. Further, the benefits of computational downscaling in low sensitivity MHz-OCT systems are analyzed.}, } |
Elisabeth
Richert,
Claus
von der Burchard,
Alexa
Klettner,
Patrik
Arnold,
Ralph
Lucius,
Ralf
Brinkmann,
Johann
Roider, and
Jan
Tode,
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models, 09 2020.
Datei: | S2590153220300112 |
Bibtex: | ![]() @article{RN5351, author = {Richert, E;von der Burchard, C;Klettner, A;Arnold, P;Lucius, R;Brinkmann, R;Roider, J and Tode, J}, title = {Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models}, journal = {Cytokine: X}, volume = {2}, number = {3}, pages = {100031}, ISSN = {2590-1532}, DOI = {https://doi.org/10.1016/j.cytox.2020.100031}, url = {https://www.sciencedirect.com/science/article/pii/S2590153220300112}, year = {2020}, type = {Journal Article} } |
Matthias
Strauch,
Jan Philip
Kolb,
Daniel
Weng,
Melanie
Wacker,
Wolfgang
Draxinger,
Nadine
Merg,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Two-photon microscopy for sectioning-free virtual H&E imaging, in 104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie , 062020.
Two-photon microscopy for sectioning-free virtual H&E imaging, in 104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie , 062020.
Weblink: | https://www.pathologie-dgp.de/media/Dgp/user_upload/Verhandlungsband_2020_final__kompr._.pdf |
Bibtex: | ![]() @InProceedings{Strauch2020, author = {M. Strauch, J.P. Kolb, D. Weng, M. Wacker, W. Draxinger, N. Merg, J. Hundt, S. Karpf and R. Huber}, booktitle = {104. Jahrestagung der Deutschen Gesellschaft fuer Pathologie}, title = {Two-photon microscopy for sectioning-free virtual {H&E} imaging}, URL = {https://www.pathologie-dgp.de/media/Dgp/user_upload/Verhandlungsband_2020_final__kompr._.pdf}, year = {2020}, keywords = {AG-Huber_NL}, } |
Mark
Schmidt,
Tom
Pfeiffer,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers, OSA Continuum , vol. 3, no. 6, pp. 1589--1607, 06 2020. Optical Society of America.
DOI: | 10.1364/OSAC.389972 |
Bibtex: | ![]() @article{schmidt2020self, title={Self-stabilization mechanism in ultra-stable Fourier domain mode-locked (FDML) lasers}, author={M. {Schmidt}, T. {Pfeiffer}, C. {Grill}, R. {Huber} and C. {Jirauschek}}, journal={OSA Continuum}, volume={3}, number={6}, pages={1589--1607}, year={2020}, keywords={AG-Huber_FDML}, url={https://doi.org/10.1364/OSAC.389972}, publisher= {Optical Society of America} } |
Matthias Strauch,
Tunable Optics: Spectral Imaging and Surface Manipulation on Liquid Lenses, Delft University of Technology, Delft, 03 2020.
Tunable Optics: Spectral Imaging and Surface Manipulation on Liquid Lenses, Delft University of Technology, Delft, 03 2020.
DOI: | 10.4233/uuid:b61aa64e-cba4-44c0-8d16-93440e028611 |
Bibtex: | ![]() @PhdThesis{Strauch2020, author = {M. Strauch}, title = {Tunable Optics: Spectral Imaging and Surface Manipulation on Liquid Lenses}, institution = {Delft University of Technology}, year = {2020}, date = {2020-03-30}, type = {phdthesis}, subtitle = {Spectral Imaging and Surface Manipulation on Liquid Lenses}, language = {English}, isbn = {978-94-028-1994-6}, pagetotal = {151}, doi = {10.4233/uuid:b61aa64e-cba4-44c0-8d16-93440e028611}, abstract = {This thesis focusses on two aspects of tunable optics: Fabry-P{\'e}rot interferometers with a variable distance between their mirrors and electrowetting liquid lenses. The need for a device to detect child abuse has motivated us to design and build a camera that can detect the chemical composition of the upper skin layers of a bruise using a self-made Fabry-P{\'e}rot interferometer. The research described in the first part of this thesis has shown that wide-angle spectral imaging can be achieved with compact and cost-effective cameras using Fabry-P{\'e}rot interferometers. Designs with a full field of 90° in which the Fabry-P{\'e}rot interferometer is mounted either in front of an imaging system or behind a telecentric lens system are presented and analysed. The dependency of the spectral resolution on the numerical aperture of the lens system is derived and its value as a design criterion is shown. It is shown that the telecentric camera design is preferable over the collimated design for bruise imaging with a Fabry-P{\'e}rot interferometer.The idea to use a liquid lens for spectral imaging has directed the research towards a new concept of controlling surface waves on the surface of a liquid lens. We investigate and model surface waves because they decrease the imaging quality during fast focal switching. We propose a model that describes the surface modes appearing on a liquid lens and that predicts the resonance frequencies. The effects of those surface modes on a laser beam are simulated using geometrical optics and Fresnel propagation, and the model is verified experimentally. The model of the surface oscillations is used to develop a technique to create aspheric surface shapes on commercially available electrowetting liquid lenses. The surface waves on the liquid lens are described by Bessel functions of which a linear combination can be used to create any circularly symmetrical aspheric lens shape at an instant of time. With these surface profiles, one can realise a large set of circularly symmetrical wavefronts and hence intensity distributions of beams transmitted by the lens. The necessary liquid lens actuation to achieve a desired shape is calculated via a Hankel transform and confirmed experimentally. The voltage signal can be repeated at video rate. Measurements taken with a Mach-Zehnder interferometer confirm the model of the surface waves. The capabilities and limitations of the proposed method are demonstrated using the examples of a Bessel surface, spherical aberration, an axicon, and a top hat structure.}, keywords = {AG-Huber}, address = {Delft}, publisher = {Delft University of Technology}, school = {Delft University of Technology}, } |
Paul
Strenge,
Birgit
Lange,
Christin
Grill,
Wolfgang
Draxinger,
Matteo M.
Bonsanto,
Christian
Hagel,
Robert
Huber, and
Ralf
Brinkmann,
Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV , SPIE, 022020. pp. 82 -- 89.
Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis, in Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV , SPIE, 022020. pp. 82 -- 89.
DOI: | 10.1117/12.2545659 |
Bibtex: | ![]() @inproceedings{Strenge2020, author = {P. Strenge and B. Lange and C. Grill and W. Draxinger and M. M. Bonsanto and C. Hagel and R. Huber and R. Brinkmann}, title = {{Segmented OCT data set for depth resolved brain tumor detection validated by histological analysis}}, volume = {11228}, booktitle = {Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV}, editor = {Joseph A. Izatt and James G. Fujimoto}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {82 -- 89}, keywords = {AG-Huber_OCT, Optical coherence tomography, OCT, FDML Laser, MHz-OCT, brain tumor, brain imaging, neurosurgery}, year = {2020}, URL = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11228/112282O/Segmented-OCT-data-set-for-depth-resolved-brain-tumor-detection/10.1117/12.2545659.short} } |
Christin
Grill,
Simon
Lotz,
Torben
Blömker,
Dominic
Kastner,
Tom
Pfeiffer,
Mark
Schmidt,
Wolfgang
Draxinger,
Christian
Jirauschek, and
Robert
Huber,
Beating of two FDML lasers in real time, in Fiber Lasers XVII: Technology and Systems , Liang Dong, Eds. SPIE, 022020. pp. 132 -- 138.
Beating of two FDML lasers in real time, in Fiber Lasers XVII: Technology and Systems , Liang Dong, Eds. SPIE, 022020. pp. 132 -- 138.
DOI: | 10.1117/12.2545794 |
Bibtex: | ![]() @inproceedings{Grill2020, author = {C. {Grill}, S. {Lotz}, T. {Blömker}, D. {Kastner}, T. {Pfeiffer}, S. {Karpf}, M. {Schmidt}, W. {Draxinger}, C. {Jirauschek} and R. {Huber}}, title = {{Beating of two FDML lasers in real time}}, volume = {11260}, booktitle = {Fiber Lasers XVII: Technology and Systems}, editor = {Liang Dong}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {132 -- 138}, keywords = {AG-Huber_FDML, FDML laser, fiber lasers, beat signal, OCT, Optical Coherence Tomography, Fourier domain mode locking}, year = {2020}, doi = {10.1117/12.2545794}, } |
Leonardo
Cecchetti,
Tianshi
Wang,
Ayla
Hoogendoorn,
Karen T.
Witberg,
Jurgen M. R.
Lighthart,
Joost
Daemen,
Heleen
van Beusekom,
Tom
Pfeiffer,
Robert
Huber,
Jolanda
Wentzel,
Antonius F. W.
van der Steen, and
Gijs
van Soest,
In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT, The International Journal of Cardiovascular Imaging , vol. 36, no. 6, pp. 1021-1029, 02 2020. Springer Science and Business Media LLC.
In-vitro and in-vivo imaging of coronary artery stents with Heartbeat OCT, The International Journal of Cardiovascular Imaging , vol. 36, no. 6, pp. 1021-1029, 02 2020. Springer Science and Business Media LLC.
DOI: | 10.1007/s10554-020-01796-7 |
Bibtex: | ![]() @article{Cecchetti2020, doi = {10.1007/s10554-020-01796-7}, url = {https://doi.org/10.1007/s10554-020-01796-7}, year = {2020}, month = feb, publisher = {Springer Science and Business Media {LLC}}, volume = {36}, number = {6}, pages = {1021--1029}, author = {Leonardo Cecchetti and Tianshi Wang and Ayla Hoogendoorn and Karen T. Witberg and Jurgen M. R. Ligthart and Joost Daemen and Heleen M. M. van Beusekom and Tom Pfeiffer and Robert A. Huber and Jolanda J. Wentzel and Antonius F. W. van der Steen and Gijs van Soest}, title = {In-vitro and in-vivo imaging of coronary artery stents with Heartbeat {OCT}}, journal = {The International Journal of Cardiovascular Imaging} } |
Carolin
Elhardt,
Christian M.
Wertheimer,
Andreas
Wartak,
Stefan
Kassumeh, and
Reginald
Birngruber,
Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography, Translational Vision Science & Technology , vol. 9(5), pp. 6-6, 2020.
Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography, Translational Vision Science & Technology , vol. 9(5), pp. 6-6, 2020.
Datei: | tvst.9.5.6 |
Bibtex: | ![]() @article{Birngruber2020, author = {Elhardt, C;Wertheimer, C M.;Wartak, A;Zhao, J;Leung, H M;Kassumeh, S A.;Yin, B;Tearney, G J. and Birngruber, R}, title = {Stromal Nerve Imaging and Tracking Using Micro-Optical Coherence Tomography}, journal = {Translational Vision Science & Technology}, volume = {9(5)}, pages = {6-6}, ISSN = {2164-2591}, Keywords = {optical coherence tomography; micro-OCT; imaging;corneal nerves; diabetes}, url = {https://doi.org/10.1167/tvst.9.5.6}, year = {2020}, type = {Journal Article} } |
Jalali,
Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates, Nature Communications , vol. 11(1), pp. 2062, 2020.
Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates, Nature Communications , vol. 11(1), pp. 2062, 2020.
Datei: | s41467-020-15618-w |
Bibtex: | ![]() @article{Karpf-2020, author = {S. Karpf, C.T. Riche, D. Di Carlo, A. Goel, W.A. Zeiger, A. Suresh, C. Portera-Cailliau B. and Jalali}, title = {Spectro-temporal encoded multiphoton microscopy and fluorescence lifetime imaging at kilohertz frame-rates}, journal = {Nature Communications}, volume = {11(1)}, keywords={}, pages = {2062}, ISSN = {2041-1723}, url = {https://doi.org/10.1038/s41467-020-15618-w}, year = {2020}, type = {Journal Article} } |
Antonio
López-Marín,
Geert
Springeling,
Robert
Beurskens,
Heleen
van Beusekom,
Antonius F. W.
van der Steen,
Arjun D.
Koch,
Brett E.
Bouma, and
Tianshi
Wang,
Shadow-free motorized capsule enables accurate beam positioning and sectorized OCT imaging of the esophagus, in Endoscopic Microscopy XV , International Society for Optics and Photonics, 2020. pp. 112140O.
Shadow-free motorized capsule enables accurate beam positioning and sectorized OCT imaging of the esophagus, in Endoscopic Microscopy XV , International Society for Optics and Photonics, 2020. pp. 112140O.
Datei: | 12.2545689 |
Bibtex: | ![]() @inproceedings{Lopez2020, author = {López-Marín, Antonio;Springeling, Geert;Beurskens, Robert;Van Beusekom, Heleen;van der Steen, Antonius;Koch, Arjun D;Bouma, Brett E;Huber, Robert A;Van Soest, Gijs and Wang, Tianshi}, title = {Shadow-free motorized capsule enables accurate beam positioning and sectorized OCT imaging of the esophagus}, booktitle = {Endoscopic Microscopy XV}, publisher = {International Society for Optics and Photonics}, volume = {11214}, pages = {112140O}, url = { https://doi.org/10.1117/12.2545689}, type = {Conference Proceedings} } |
G Deen,
Thermo-elastic optical coherence microscopy, in Proc.SPIE , International Society for Optics and Photonics, 2020. pp. 112520H.
Thermo-elastic optical coherence microscopy, in Proc.SPIE , International Society for Optics and Photonics, 2020. pp. 112520H.
DOI: | 10.1117/12.2550998 |
Datei: | 12.2550998 |
Bibtex: | ![]() @inproceedings{Deen2020, author = {Deen, A D;Pfeiffer, T;H, van Beusekom.;Essers, J;Huber, R;van der Steen, A.F.W.;van Soest, G and Wang, T}, title = {Thermo-elastic optical coherence microscopy}, booktitle = {Proc.SPIE}, volume = {11252}, abstarct = {The absorption of laser pulses by tissue leads not only to the generation of acoustic waves, but also to nanometer to sub-micrometer scale displacement. After the initial expansion, a quasi-steady state is achieved in a few microseconds. Previously we introduced the concept of thermo-elastic optical coherence tomography (TE-OCT) to \visualise" the rapid thermo-elastic expansion by measuring the Doppler phase shift rather than \listening" to the acoustic wave as in photoacoustic imaging. In this study, we built a microscopic setup for high-speed 3D TE-OCT imaging, by means of thermo-elastic optical coherence microscopy (TE-OCM). The repetition rate of pulsed laser was set to 100 Hz and the line rate of the OCT system is 1.5 MHz. The OCT beam and the laser pulse were focused upon the same location on the sample FWHM spot sizes of 300 m for the pulsed laser and 40 m FWHM for the OCT beam. For each laser pulse, an M-mode OCT image consisting of 90 A-lines was acquired. The Doppler phase shift was extracted by comparing the phase signal before and after the pulse arrival. Within 6 minutes, a 3D TE-OCM image (10 x 10 x 4 mm3) can be acquired and processed. Imaging experiments were carried out in swine meat using 1210 nm excitation wavelength to highlight lipid in tissue. The results show that no signicant displacement was detected in swine muscle while strong displacement was observed in lipid, owing to the optical absorption features. Furthermore, fatty tissue is easily identied in the 3D TE-OCM image while the conventional OCT images provides the structural information.}, pages = {112520H}, DOI = {10.1117/12.2550998}, url = {https://doi.org/10.1117/12.2550998}, type = {Conference Proceedings} } |
Tianshi
Wang,
Aaron Doug
Deen,
Heleen
van Beusekom, and
Antonius F. W.
van der Steen,
Thermo-elastic optical coherence microscopy, in Advanced Chemical Microscopy for Life Science and Translational Medicine , International Society for Optics and Photonics, 2020. pp. 112520H.
Thermo-elastic optical coherence microscopy, in Advanced Chemical Microscopy for Life Science and Translational Medicine , International Society for Optics and Photonics, 2020. pp. 112520H.
DOI: | https://doi.org/10.1117/12.2550998 |
Datei: | 12.2550998.short |
Bibtex: | ![]() @inproceedings{Deen2020, author = {Deen, Aaron Doug;Pfeiffer, Tom;Van Beusekom, Heleen;Essers, Jeroen;Huber, Robert;van der Steen, Antonius FW;Van Soest, Gijs and Wang, Tianshi}, title = {Thermo-elastic optical coherence microscopy}, booktitle = {Advanced Chemical Microscopy for Life Science and Translational Medicine}, publisher = {International Society for Optics and Photonics}, url = { https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11252/112520H/Thermo-elastic-optical-coherence-microscopy/10.1117/12.2550998.short} volume = {11252}, pages = {112520H}, type = {Conference Proceedings} } |
Sonja
Jäckle,
Veronica
Garcia-Vazquez,
Tim
Eixmann,
Florian
Matysiak,
Felix
von Haxthausen,
Malte Maria
Sieren,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Floris
Ernst,
Markus
Kleemann, and
Torben
Pätz,
Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair, Int J Comp Assis Radiology and Surgery , 2020.
Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair, Int J Comp Assis Radiology and Surgery , 2020.
ISBN: | 1861-6429 |
Datei: | s11548-020-02167-2 |
Bibtex: | ![]() @article{jackle2020, title = {Three-dimensional guidance including shape sensing of a stentgraft system for endovascular aneurysm repair}, author = {Jäckle,S; Garcia-Vazquez,V; Eixmann, T; Matysiak, F; von Haxthausen,F; Sieren; M m; Schulz-Hildebrandt, H; H\"{u}ttmann, G; Ernst, F; Kleemann, M and P\"{a}tz, T}, url = {https://doi.org/10.1007/s11548-020-02167-2}, isbn = {1861-6429}, year = {2020}, date = {2020-04-06}, journal = {Int J Comp Assis Radiology and Surgery}, abstract = {During endovascular aneurysm repair (EVAR) procedures, medical instruments are guided with two-dimensional (2D) fluoroscopy and conventional digital subtraction angiography. However, this requires X-ray exposure and contrast agent is used, and the depth information is missing. To overcome these drawbacks, a three-dimensional (3D) guidance approach based on tracking systems is introduced and evaluated.}, keywords = {HSH}, pubstate = {published}, tppubtype = {article} } |
J A.
Kilin, and
J-P
Wolf,
Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles, ACS Nano , vol. 14(4), pp. 4087-4095, 2020.
Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles, ACS Nano , vol. 14(4), pp. 4087-4095, 2020.
Datei: | acsnano.9b08813 |
Bibtex: | ![]() @article{Vogel-2020, author = {Kilin, V;Campargue, G;Fureraj, I;Sakong, S;Sabri, T;Riporto, F;Vieren, A;Mugnier, Y;Mas, C;Staedler, D;Collins, J M;Bonacina, L;Vogel, A;Capobianco, J A. and Wolf, J-P}, title = {Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles}, journal = {ACS Nano}, volume = {14(4)}, pages = {4087-4095}, ISSN = {1936-0851}, url = {https://doi.org/10.1021/acsnano.9b08813}, year = {2020}, type = {Journal Article} } |
Manabu
Yamamoto,
Yoko
Miura,
Akika
Kyo,
Kumiko
Hirayama,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann, and
Shigeru
Honda,
Selective retina therapy for subretinal fluid associated with choroidal nevus, Amer J Ophthalm Case Rep , vol. 19, pp. 100794, 2020.
Selective retina therapy for subretinal fluid associated with choroidal nevus, Amer J Ophthalm Case Rep , vol. 19, pp. 100794, 2020.
DOI: | https://doi.org/10.1016/j.ajoc.2020.100794 |
Bibtex: | ![]() @article{yamamoto2020, author = {Yamamoto, M;Miura, Y;Kyo, A;Hirayama, K;Kohno, T;Theisen-Kunde, D;Brinkmann, R and Honda, S}, title = {Selective retina therapy for subretinal fluid associated with choroidal nevus}, journal = {Amer J Ophthalm Case Rep}, volume = {19}, pages = {100794}, ISSN = {2451-9936}, keywords = {Laser therapy, Choroidal tumor, Retinal pigment epithelium, Retinal disorder}, DOI = {https://doi.org/10.1016/j.ajoc.2020.100794}, year = {2020}, type = {Journal Article} } |
Andreas
Wartak, and
G J.
Tearney,
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures, Biomedical Optics Express , vol. 11(10), pp. 5920-5933, 2020.
Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures, Biomedical Optics Express , vol. 11(10), pp. 5920-5933, 2020.
DOI: | https://doi.org/10.1364/BOE.402971 |
Bibtex: | ![]() @article{Wartak2020, author = {Wartak, A;Schenk, M S.;Bühler, V;Kassumeh, S A.;Birngruber, R and Tearney, G J.}, title = {Micro-optical coherence tomography for high-resolution morphologic imaging of cellular and nerval corneal micro-structures}, keywords = {High numerical aperture optics,Image metrics,Image processing,Image quality,Optical coherence tomography,Optical imaging}, journal = {Biomedical Optics Express}, volume = {11(10)}, DOI = { https://doi.org/10.1364/BOE.402971}, pages = {5920-5933}, year = { 2020}, type = {Journal Article} } |
Kumiko
Hirayama,
Manabu
Yamamoto,
Takeya
Kohno,
Akika
Kyo,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Yoko
Miura, and
Shigeru
Honda,
Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome, Graefes Arch Clin Exp Ophthalmol , vol. 259, pp. 387-393, 2020.
Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome, Graefes Arch Clin Exp Ophthalmol , vol. 259, pp. 387-393, 2020.
DOI: | 10.1007/s00417-020-04931-1 |
Bibtex: | ![]() @article{Hirayama2020, author = {Hirayama, K.;Yamamoto, M.;Kohno, T.;Kyo, A.;Theisen-Kunde, D.;Brinkmann, R.;Miura, Y. and Honda, S.}, title = {Selective retina therapy (SRT) for macular serous retinal detachment associated with tilted disc syndrome}, journal = {Graefes Arch Clin Exp Ophthalmol}, ISSN = {0721-832x}, volume = {259}, pages = {387-393}, DOI = {10.1007/s00417-020-04931-1}, year = {2020}, type = {Journal Article} } |
Christian M.
Wertheimer,
Katharina
Brandt,
Steffen
Kaminsky,
Carolin
Elhardt,
Stefan
Kassumeh,
Linh
Pham,
Hinnerk
Schulz-Hildebrandt,
Siegfried
Priglinger,
R.Rox
Anderson, and
Reginald
Birngruber,
Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia, J Refractive Surg , no. 6(36), pp. 406--413, 2020.
Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia, J Refractive Surg , no. 6(36), pp. 406--413, 2020.
Datei: | refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia |
Bibtex: | ![]() @article{Wertheimer2020, author = {Wertheimer, C M; Brandt, K; Kaminsky, S; Elhardt, C; Kassumeh, S A; Pham, L; Schulz-Hildebrandt, H; Priglinger, S; Anderson, R R and Birngruber, R}, url = {https://www.healio.com/ophthalmology/journals/jrs/2020-6-36-6/%7B8e6aaf40-922c-4998-9c7b-39b47135ec61%7D/refractive-changes-after-corneal-stromal-filler-injection-for-the-correction-of-hyperopia}, journal = {J Refractive Surg}, number = {6(36)}, pages = {406--413}, title = {Refractive Changes After Corneal Stromal Filler Injection for the Correction of Hyperopia}, date = {2020-06-14}, year = {2020}, keywords ={mOCT, HSH} } |
Yoko Miura,
Retinal Pigment Epithelium Organ Culture, in Retinal Pigment Epithelium in Health and Disease , Springer, 2020, pp. 307-324.
Retinal Pigment Epithelium Organ Culture, in Retinal Pigment Epithelium in Health and Disease , Springer, 2020, pp. 307-324.
Datei: | 978-3-030-28384-1_18 |
Bibtex: | ![]() @inbook{Miura2020, author = {Miura, Yoko}, title = {Retinal Pigment Epithelium Organ Culture}, booktitle = {Retinal Pigment Epithelium in Health and Disease}, publisher = {Springer}, pages = {307-324}, year = {2020}, type = {Book Section}, URL = { https://link.springer.com/chapter/10.1007/978-3-030-28384-1_18} } |
Elisabeth
Richert,
Julia
Papenkort,
Alexa
Klettner,
Jan
Tode,
Stefan
Koinzer,
Ralf
Brinkmann,
Christine
Fink,
Thomas
Roeder,
Ralph
Lucius, and
Johann
Roider,
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR), Lasers in Surgery and Medicine , 2020.
Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR), Lasers in Surgery and Medicine , 2020.
DOI: | DOI 10.1002/lsm.23288 |
Bibtex: | ![]() @article{Richert2020, author = {Richert, E;Papenkort, J;Klettner, A;Tode, J;Koinzer, S;Brinkmann, R;Fink, C;Roeder, T;Lucius, R. and Roider, J}, title = {Response of Retinal Pigment Epithelium (RPE)‐Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR)}, journal = {Lasers in Surgery and Medicine}, Keywords = {age‐related macular degeneration; thermal stimulation therapy of the retinal pigment epithelium; matrix metalloproteases; pigment epithelium derived factor; retinal pigment epithelium; vascular endothelial growth factor; transforming growth factor‐β}, DOI = {DOI 10.1002/lsm.23288}, year = {2020}, type = {Journal Article} } |
Matthias
Strauch,
Jan Philip
Kolb,
Nadine
Merg,
Jennifer
Hundt,
Sebastian
Karpf, and
Robert
Huber,
Evaluation of two-photon fluorescence microscopy for sectioning-free H&E imaging of different tissues, in 32nd Congress of the ESP and XXXIII International Congress of the IAP , 2020.
Evaluation of two-photon fluorescence microscopy for sectioning-free H&E imaging of different tissues, in 32nd Congress of the ESP and XXXIII International Congress of the IAP , 2020.
DOI: | 10.1007/s00428-020-02938-x |
Bibtex: | ![]() @InProceedings{Strauch2020a, author = {M. Strauch, J.P. Kolb, N. Merg, J. Hundt, S. Karpf and R. Huber}, booktitle = {32nd Congress of the ESP and XXXIII International Congress of the IAP}, title = {Evaluation of two-photon fluorescence microscopy for sectioning-free {H&E} imaging of different tissues}, year = {2020}, keywords = {AG-Huber_NL}, } |
Manabu
Yamamoto,
Yoko
Miura,
Kumiko
Hirayama,
Takeya
Kohno,
Daijiro
Kabata,
Dirk
Theisen-Kunde,
Ralf
Brinkmann, and
Shigeru
Honda,
Predictive factors of outcome of selective retina therapy for diabetic macular edema, International Ophthalmology , 2020.
Predictive factors of outcome of selective retina therapy for diabetic macular edema, International Ophthalmology , 2020.
Datei: | s10792-020-01288-6 |
Bibtex: | ![]() @article{Miura2020-2, author = {Yamamoto, M;Miura, Y;Hirayama, K;;Kohno, T;Kabata, D;Theisen-Kunde, D;Brinkmann, R and Honda, S;}, title = {Predictive factors of outcome of selective retina therapy for diabetic macular edema}, journal = {International Ophthalmology}, ISSN = {1573-2630}, url = {https://doi.org/10.1007/s10792-020-01288-6}, year = {2020}, type = {Journal Article} } |
A
Holzhey, and
Mahdy
Ranjbar,
Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss, Journal of visualized experiments: JoVE , no. 158, 2020.
Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss, Journal of visualized experiments: JoVE , no. 158, 2020.
DOI: | 10.3791/60542 |
Bibtex: | ![]() @article{Holzhey2020, author = {Holzhey, A;Sonntag, S;Rendenbach, J;Ernesti, J S;Kakkassery, V;Grisanti, S;Reinholz, F;Freidank, S;Vogel, A and Ranjbar, M}, title = {Development of a Noninvasive, Laser-Assisted Experimental Model of Corneal Endothelial Cell Loss}, journal = {Journal of visualized experiments: JoVE}, number = {158}, ISSN = {1940-087X}, DOI = {10.3791/60542 }, year = {2020}, type = {Journal Article} } |
Hartmut
Schneider,
Martin
Ahrens,
Michaela
Strumpski,
Claudia
Rüger,
Matthias
Häfer,
Gereon
Hüttmann,
Dirk
Theisen-Kunde,
Hinnerk
Schulz-Hildebrandt, and
Rainer
Haak,
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations, J Clin Med , vol. 9(10), 2020.
DOI: | 10.3390/jcm9103257 |
Bibtex: | ![]() @article{schneider2020, author = {Schneider, H.;Ahrens, M.;Strumpski, M.;Ruger, C.;Hafer, M.;Huettmann, G.;Theisen-Kunde, D.;Schulz-Hildebrandt, H. and Haak, R.}, title = {An Intraoral OCT Probe to Enhanced Detection of Approximal Carious Lesions and Assessment of Restorations}, journal = {J Clin Med}, volume = {9(10)}, keywords = {OCT; intraoral probe; carious lesions; caries diagnosis; dental restorations}, ISSN = {2077-0383 (Print) 2077-0383 (Linking)}, DOI = {10.3390/jcm9103257}, year = {2020}, type = {Journal Article} } |
Cuiping
Yao,
Florian
Rudnitzki,
Yida
He,
Zhenxi
Zhang,
Gereon
Hüttmann, and
Ramtin
Rahmanzadeh,
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods, JBio , 2020.
DOI: | 10.1002/jbio.202000017 |
Bibtex: | ![]() @article{Rahmanzadeh-2020, author = {Yao, C;Rudnitzki, F;He, Y;Zhang, Z;Hüttmann, G and Rahmanzadeh, R}, title = {Cancer cell-specific protein delivery by optoporation with laser-irradiated gold nanorods}, journal = {JBio}, ISSN = {1864-063X}, DOI = {10.1002/jbio.202000017}, Year = {2020}, type = {Journal Article} } |
Markus
Luecking,
Ralf
Brinkmann,
Scarlett
Ramos,
Wilhelm
Stork, and
Nico
Heussner,
Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage, CompBioMed , vol. 122, pp. 103835, 2020.
Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage, CompBioMed , vol. 122, pp. 103835, 2020.
DOI: | https://doi.org/10.1016/j.compbiomed.2020.103835 |
Bibtex: | ![]() @article{brinkmann2020-2, author = {Luecking, M;Brinkmann, R;Ramos, Sc;Stork, W and Heussner, N}, title = {Capabilities and limitations of a new thermal finite volume model for the evaluation of laser-induced thermo-mechanical retinal damage}, journal = {CompBioMed}, volume = {122}, pages = {103835}, ISSN = {0010-4825}, DOI = {https://doi.org/10.1016/j.compbiomed.2020.103835}, year = {2020}, type = {Journal Article} } |
Asylkhan E.
Rakhymzhan,
Lucie
Reuter,
Raphael
Raspe,
Daniel
Bremer,
Judith
Heidelin,
Volker
Andresen,
Robert
Günther,
Ruth
Leben,
Sergey
Cheremukhin,
Hinnerk
Schulz-Hildebrandt,
Maria G.
Bixel,
Ralf H.
Adams,
Helena
Radbruch,
Gereon
Hüttmann,
Anja E.
Hauser, and
Raluca A.
Niesner,
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging, Cytometry Part A , vol. 97, no. 5, pp. 515-527, 2020.
DOI: | 10.1002/cyto.a.24012 |
Bibtex: | ![]() @article{Schulz-Hildebrandt-2020, author = {Rakhymzhan, A;Reuter, L;Raspe, R;Bremer, D;Günther, R;Leben, R;Heidelin, J;Andresen, V;Cheremukhin, S;Schulz-Hildebrandt, H;Bixel, M G.;Adams, R H.;Radbruch, H;Hüttmann, G;Hauser, A E. and Niesner, R A.}, title = {Coregistered Spectral Optical Coherence Tomography and Two-Photon Microscopy for Multimodal Near-Instantaneous Deep-Tissue Imaging}, year = {2020}, journal = {Cytometry Part A}, volume = {97}, number = {5}, pages={515-527}, ISSN = {1552-4922}, DOI = {10.1002/cyto.a.24012}, type = {Journal Article} } |
Stefan
Kassumeh,
Christian M.
Wertheimer,
Katharina
Brandt,
Siegfried
Priglinger,
Andreas
Wartak,
Gabriela
Apiou-Sbirlea,
R.Rox
Anderson, and
Reginald
Birngruber,
Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study, TVST , vol. 9(7), pp. 30-30, 2020.
Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study, TVST , vol. 9(7), pp. 30-30, 2020.
Datei: | tvst.9.7.30 |
Bibtex: | ![]() @article{Kassumeh2020, author = {Kassumeh, S;Luther, J K.;Wertheimer, C M.;Brandt, K;Schenk, M S.;Priglinger, S G.;Wartak, A;Apiou-Sbirlea, G.;Anderson, R. R. and Birngruber, R}, title = {Corneal Stromal Filler Injection as a Novel Approach to Correct Presbyopia—An Ex Vivo Pilot Study}, journal = {TVST}, volume = {9(7)}, keywords = { presbyopia correction; corneal filler; refractive surgery; femtosecond laser; hyaluronic acid; bifocality}, pages = {30-30}, ISSN = {2164-2591}, url = {https://doi.org/10.1167/tvst.9.7.30}, year = {2020}, type = {Journal Article} } |
Vasily
Matkivsky,
Alexander
Moiseev,
Pavel
Shilyagin,
Alexander
Rodionov,
Hendrik
Spahr,
Clara
Pfäffle,
Gereon
Hüttmann,
Dierck
Hillmann, and
Grigory
Gelikonov,
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function, Journal of Biophotonics , vol. 13(10), pp. e202000112, 2020.
DOI: | 10.1002/jbio.202000112 |
Bibtex: | ![]() @article{Matkivsky2020, author = {Matkivsky, V;Moiseev, A;Shilyagin, P;Rodionov, A;Spahr, H;Pfäffle, C;Hüttmann, G;Hillmann, D and Gelikonov, G}, title = {Determination and correction of aberrations in full field optical coherence tomography using phase gradient autofocus by maximizing the likelihood function}, journal = {Journal of Biophotonics}, volume = {13(10)}, pages = {e202000112}, ISSN = {1864-063X}, DOI = {10.1002/jbio.202000112}, year = {2020}, type = {Journal Article} } |
Michael
Münter,
Mario
Pieper,
Malte
Casper,
Martin
Ahrens,
Tabea
Kohlfaerber,
Ramtin
Rahmanzadeh,
Peter
König,
Gereon
Hüttmann, and
Hinnerk
Schulz-Hildebrandt,
Dynamic contrast in scanning microscopic OCT, Optic Letters , 2020.
Dynamic contrast in scanning microscopic OCT, Optic Letters , 2020.
Datei: | 2003.00006 |
Bibtex: | ![]() @article{Münter2020, author = {Münter, M;Endt, M v;Pieper, M;Casper, M;Ahrens, M;Kohlfaerber, T;Rahmanzadeh, R;König, P;Hüttmann, G and Schulz-Hildebrandt, H}, title = {Dynamic contrast in scanning microscopic OCT}, journal = {Optic Letters}, url = {https://arxiv.org/abs/2003.00006}, year = {2020}, type = {Journal Article} } |
Matthias
Müller,
Ramtin
Rahmanzadeh,
Thao
Tran,
Jan
Kappelhoff,
Eman Aburieda
Akam,
Peter
Caravan,
Thomas
Jüstel,
Kathryn D
Held,
R.Rox
Anderson, and
Martin
Purschke,
Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells, Particle and Particle Systems Characterization , 2020.
Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells, Particle and Particle Systems Characterization , 2020.
DOI: | 10.1002/ppsc.202000201 |
Datei: | 0 |
Bibtex: | ![]() @article{Müller2020, author = {Müller M;Rahmanzadeh R;Tran T;Kappelhoff J;Akam EA;Caravan P;Jüstel T;Held KD;Anderson R and M, and Purschke}, title = {Particle size of X-ray pumped UVC emitting nanoparticles defines intracellular localization and biological activity against cancer cells}, journal = {Particle and Particle Systems Characterization }, year = {2020}, type = {Journal Article}, url = { https://onlinelibrary.wiley.com/toc/15214117/0/0} } |
Elisabeth
Richert,
Sofya
Bartsch,
Jost
Hillenkamp,
Felix
Treumer,
Jan
Tode,
Claus
von der Burchard,
Ralf
Brinkmann,
Alexa
Klettner, and
Johann
Roider,
Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums, Klin Monatsbl Augenheilkd , vol. 237(02), pp. 192-201, 2020.
Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums, Klin Monatsbl Augenheilkd , vol. 237(02), pp. 192-201, 2020.
DOI: | 10.1055/a-0838-5633 |
Datei: | a-0838-5633 |
Bibtex: | ![]() @article{Brinkmann2020, author = {Richert, E;Bartsch, S;Hillenkamp, J;Treumer, F;Tode, J;von der Burchard, C;Brinkmann, R;Klettner, A K and Roider, J}, title = {Einfluss der Selektiven Retinatherapie (SRT) auf inflammatorische Zellmediatoren des subretinalen Raums}, journal = {Klin Monatsbl Augenheilkd}, volume = {237(02)}, pages = {192-201}, ISSN = {0023-2165}, DOI = {10.1055/a-0838-5633}, year = {2020}, type = {Journal Article} } |
Tobias
Fischer,
Antje
Klinger,
Dorthe
Smolinski,
Regina
Orzekowsky-Schröder,
Falk
Nitzsche,
Alfred
Vogel,
Gereon
Hüttmann, and
Andreas
Gebert,
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures, Cell and Tissue Research , pp. 1-8, 2020.
Datei: | s00441-020-03167-z |
Bibtex: | ![]() @article{Fischer2020, author = {Fischer, T;Klinger, A;von Smolinski, D;Orzekowsky-Schroeder, R;Nitzsche, F;Bölke, T;Vogel, A;Hüttmann, G and Gebert, A}, title = {High-resolution imaging of living gut mucosa: lymphocyte clusters beneath intestinal M cells are highly dynamic structures}, journal = {Cell and Tissue Research}, pages = {1-8}, ISSN = {1432-0878}, url = {https://doi.org/10.1007/s00441-020-03167-z}, year = {2020}, type = {Journal Article} } |
G
Pieper, and
P
K\"{o}nig,
Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice, American Journal of Physiology-Lung Cellular and Molecular Physiology , vol. 318, no. 3, pp. 518-524, 2020. American Physiological Society Rockville, MD.
Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice, American Journal of Physiology-Lung Cellular and Molecular Physiology , vol. 318, no. 3, pp. 518-524, 2020. American Physiological Society Rockville, MD.
DOI: | 10.1152/ajplung.00287.2019 |
Bibtex: | ![]() @article{pieper2020intravital, title = {Intravital microscopic optical coherence tomography imaging to assess mucus mobilizing interventions for muco-obstructive lung disease in mice}, author = {Pieper,P; Schulz-Hildebrandt, H; Mall,Marcus A; H\"{u}ttmann, G and K\"{o}nig, P}, doi = {10.1152/ajplung.00287.2019}, year = {2020}, date = {2020-02-26}, journal = {American Journal of Physiology-Lung Cellular and Molecular Physiology}, volume = {318}, number = {3}, pages = {518-524}, publisher = {American Physiological Society Rockville, MD}, abstract = {Airway mucus obstruction is a hallmark of chronic lung diseases such as cystic fibrosis, asthma and COPD, and the development of more effective mucus mobilizing therapies remains an important unmet need for patients with these muco-obstructive lung diseases. However, methods for sensitive visualization and quantitative assessment of immediate effects of therapeutic interventions on mucus clearance in vivo are lacking. In this study, we determined if newly developed high-speed microscopic optical coherence tomography (mOCT) is sensitive to detect and compare in vivo effects of inhaled isotonic saline, hypertonic saline and bicarbonate on mucus mobilization and clearance in Scnn1b-transgenic mice with muco-obstructive lung disease. In vivomOCT imaging showed that inhaled isotonic saline-induced rapid mobilization of mucus that was mainly transported as chunks from the lower airways of Scnn1b-transgenic mice. Hypertonic saline mobilized a significantly greater amount of mucus that showed a more uniform distribution compared to isotonic saline. Addition of bicarbonate to isotonic saline had no effect on mucus mobilization, but also led to a more uniform mucus layer compared to treatment with isotonic saline alone. mOCT can detect differences in response to mucus mobilizing interventions in vivo, and may thus support the development of more effective therapies for patients with muco-obstructive lung diseases.}, keywords = {mOCT,OCT}, pubstate = {published}, tppubtype = {article} } |
Viktoria
Kleymann,
Hannaes
Gernandt,
Karl
Worthmann,
Hossam S.
Abbas,
Ralf
Brinkmann, and
Matthias A.
Müller,
Modeling parameter for temperature controlled retinal laser therapies, DeGruyter-at-Automatisierungstechnik , vol. 68(11), pp. 953-966, 2020.
Modeling parameter for temperature controlled retinal laser therapies, DeGruyter-at-Automatisierungstechnik , vol. 68(11), pp. 953-966, 2020.
Datei: | article-p953.xml |
Bibtex: | ![]() @article{Kleymann2020, author = {Kleymann, V;Gernandt, H;Worthmann, K;Hossam, S.A;Brinkmann, R and Müller, A.M}, title = {Modeling parameter for temperature controlled retinal laser therapies }, journal = {DeGruyter-at-Automatisierungstechnik}, volume = {68(11)}, keywords = {retinal photocoagulation, parametric model order reduction, identification}, pages = {953-966}, URL = {https://www.degruyter.com/view/journals/auto/68/11/article-p953.xml}, year = {2020}, type = {Journal Article} } |
M
Palczewska, and
K
Palczewski,
Noninvasive two-photon optical biopsy of retinal fluorophores, Proceedings of the National Academy of Sciences , pp. 202007527, 2020.
Noninvasive two-photon optical biopsy of retinal fluorophores, Proceedings of the National Academy of Sciences , pp. 202007527, 2020.
DOI: | 10.1073/pnas.2007527117 |
Bibtex: | ![]() @article{Palczewska-2020, title = {Noninvasive two-photon optical biopsy of retinal fluorophores}, author = {Palczewska, G;Boguslawski, J;Stremplewski, P;Kornaszewski, L;Zhang, J;Dong, Z;Liang, Xiao-Xuan;Gratton, E;Vogel, A;Wojtkowski, M and Palczewski, K}, year = 2020, journal = {Proceedings of the National Academy of Sciences}, pages = 202007527, doi = {10.1073/pnas.2007527117}, type = {Journal Article} } |
B L
Ibey, and
N.
Linz,
Optical Interactions with Tissue and Cells XXXI, in Proc. of SPIE Vol , 2020. pp. 1123801-1.
Optical Interactions with Tissue and Cells XXXI, in Proc. of SPIE Vol , 2020. pp. 1123801-1.
DOI: | 10.1117/12.2569811 |
ISBN: | ISBN: 9781510632394 |
Bibtex: | ![]() @inproceedings{Linz2020, author = {Ibey, B L and Linz, N}, title = {Optical Interactions with Tissue and Cells XXXI}, booktitle = {Proc. of SPIE Vol}, volume = {11238}, pages = {1123801-1}, year = {2020}, ISBN = {ISBN: 9781510632394}, DOI = {10.1117/12.2569811}, type = {Conference Proceedings} } |
S.
Freidank, and
N.
Linz,
Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery, TVST , vol. 9(10), pp. 22-22, 2020.
Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery, TVST , vol. 9(10), pp. 22-22, 2020.
Datei: | tvst.9.10.22 |
Bibtex: | ![]() @article{Freidank2020, author = {Freidank, S;Vogel, A and Linz, N}, title = {Optical Vortex Beam for Gentle and Ultraprecise Intrastromal Corneal Dissection in Refractive Surgery}, journal = {TVST}, volume = {9(10)}, pages = {22-22}, ISSN = {2164-2591}, url = {https://doi.org/10.1167/tvst.9.10.22}, year = {2020}, type = {Journal Article} } |
Paula
Enzian,
Christian
Schell,
Astrid
Link,
Carina
Malich,
Ralph
Pries,
Barbara
Wollenberg, and
Ramtin
Rahmanzadeh,
Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH, Molecular Pharmaceutics , 2020.
Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH, Molecular Pharmaceutics , 2020.
DOI: | 10.1021/acs.molpharmaceut.9b01173 |
Bibtex: | ![]() @article{Enzian2020, author = {Enzian, P.;Schell, C.;Link, A.;Malich, C.;Pries, R.;Wollenberg, B and Rahmanzadeh, R}, title = {Optically controlled drug release from light-sensitive liposomes with the new photosensitizer 5,10-DiOH}, journal = {Molecular Pharmaceutics}, ISSN = {1543-8384}, DOI = {10.1021/acs.molpharmaceut.9b01173}, year = {2020}, type = {Journal Article} } |
2019
Marco
Horn,
Sonja
Jäckle,
Felix
von Haxthausen,
Tim
Eixmann,
Hinnerk
Schulz-Hildebrandt,
Gereon
Hüttmann,
Juljan
Bouchagiar,
Florian
Matysiak,
Mark
Kaschwich,
Markus
Kleemann,
Floris
Ernst,
Veronica
Garcia-Vazquez, and
Torben
Pätz,
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dez. 2019. W.B. Saunders.
First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures, European Journal of Vascular and Endovascular Surgery , vol. 58, no. 6, pp. e610--e611, Dez. 2019. W.B. Saunders.
DOI: | 10.1016/J.EJVS.2019.09.091 |
Bibtex: | ![]() @proceedings{Horn2019b, title = {First Steps into Catheter Guidance Including Shape Sensing for Endovascular Aneurysm Repair Procedures}, author = {Marco Horn and Sonja J\"{a}ckle and Felix von Haxthausen and Tim Eixmann and Hinnerk Schulz-Hildebrandt and Gereon H\"{u}ttmann and Juljan Bouchagiar and Florian Matysiak and Mark Kaschwich and Markus Kleemann and Floris Ernst and Ver\'{o}nica Garc\'{i}a-V\'{a}zquez and Torben P\"{a}tz}, doi = {10.1016/J.EJVS.2019.09.091}, issn = {1078-5884}, year = {2019}, date = {2019-12-13}, journal = {European Journal of Vascular and Endovascular Surgery}, volume = {58}, number = {6}, pages = {e610--e611}, publisher = {W.B. Saunders}, keywords = {Sensing, Fiber}, pubstate = {published}, tppubtype = {proceedings} } |
Paula
Enzian,
Astrid
Link,
Christian
Schell,
Carina
Malich, and
Ramtin
Rahmanzadeh,
Light-induced permeabilization of liposomes, vol. 11070, 08 2019. Proc.SPIE.
Light-induced permeabilization of liposomes, vol. 11070, 08 2019. Proc.SPIE.
Datei: | 12.2526071 |
Bibtex: | ![]() @Proc{Enzian2019, author = {Enzian, P.;Link, A.;Schell, C.;Malich, C. and Rahmanzadeh, R.}, title = {Light-induced permeabilization of liposomes}, publisher = {Proc.SPIE}, volume = {11070}, series = {17th International Photodynamic Association World Congress}, url = {https://doi.org/10.1117/12.2526071}, year = {2019}, type = {Book} } |
Hendrik
Spahr,
Clara
Pfäffle,
Sazan
Burhan,
Lisa
Kutzner,
Felix
Hilge,
Gereon
Hüttmann, and
Dierck
Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific report , vol. 9, 08 2019.
DOI: | 10.1038/s41598-019-47979-8 |
Bibtex: | ![]() @article{RN5217, author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck}, title = {Phase-sensitive interferometry of decorrelated speckle patterns}, journal = {Scientific Reports}, volume = {9}, number = {1}, pages = {11748}, ISSN = {2045-2322}, DOI = {10.1038/s41598-019-47979-8}, url = {https://doi.org/10.1038/s41598-019-47979-8}, year = {2019}, type = {Journal Article} } |
Antonio
López-Marín,
Geert
Springeling,
Robert
Beurskens,
Heleen
van Beusekom,
Antonius F. W.
van der Steen,
Arjun D.
Koch,
Brett E.
Bouma,
Robert
Huber,
Gijs
van Soest, and
Tianshi
Wang,
Motorized capsule for shadow-free OCT imaging and synchronous beam control, Opt Lett , vol. 44, no. 15, pp. 3641-3644, 08 2019. Optica Publishing Group.
Motorized capsule for shadow-free OCT imaging and synchronous beam control, Opt Lett , vol. 44, no. 15, pp. 3641-3644, 08 2019. Optica Publishing Group.
DOI: | 10.1364/OL.44.003641 |
Bibtex: | ![]() @article{Lopez-Marin:19, author = {Antonio L\'{o}pez-Mar\'{i}n and Geert Springeling and Robert Beurskens and Heleen van Beusekom and Antonius F. W. van der Steen and Arjun D. Koch and Brett E. Bouma and Robert Huber and Gijs van Soest and Tianshi Wang}, journal = {Opt. Lett.}, keywords = {Image reconstruction; Light beams; Magnetic fields; Optical coherence tomography; Optical imaging; Reflector design}, number = {15}, pages = {3641--3644}, publisher = {Optica Publishing Group}, title = {Motorized capsule for shadow-free OCT imaging and synchronous beam control}, volume = {44}, month = {Aug}, year = {2019}, url = {https://opg.optica.org/ol/abstract.cfm?URI=ol-44-15-3641}, doi = {10.1364/OL.44.003641}, abstract = {We demonstrate a tethered motorized capsule for unobstructed optical coherence tomography (OCT) imaging of the esophagus. By using a distal reflector design, we avoided the common shadow artifact induced by the motor wires. A synchronous driving technique features three types of beam-scanning modes of the capsule, i.e., circumferential beam scanning, localized beam scanning, and accurate beam positioning. We characterized these three modes and carried out ex vivo imaging experiments using the capsule. The results show that the capsule can potentially be a useful tool for diagnostic OCT imaging and OCT-guided biopsy and therapy of the esophagus.}, } |
Yoko
Miura,
Wolfgang
Draxinger,
Christin
Grill,
Tom
Pfeiffer,
Salvatore
Grisanti, and
Robert
Huber,
MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 072019. pp. 110780E.
MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. SPIE, 072019. pp. 110780E.
DOI: | 10.1117/12.2527123 |
Bibtex: | ![]() @inproceedings{10.1117/12.2527123, author = {Yoko Miura and Wolfgang Draxinger and Christin Grill and Tom Pfeiffer and Salvatore Grisanti and Robert Huber}, title = {{MHz-OCT for low latency virtual reality guided surgery: first wet lab experiments on ex-vivo porcine eye }}, volume = {11078}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {110780E}, abstract = {MHz-OCT systems based on FDML swept laser sources combined with the massive parallel processing capabilities of modern computer hardware enable volumetric imaging, processing and stereoscopic display at video rates. The increasing image quality and speed might enable new fields of application where the volumetric OCT completely replaces stereoscopic microscopes instead of being a mere supplement. Aside from the depth resolving capability, a particular advantage is the ability to display a whole image volume from arbitrary points of view without the need to move the actual microscope or to rotate the patient’s eye. Purely digital microscopy is already offered as alternative to traditional through-an-eyepiece surgical microscope. We explore the use of virtual reality to present digital OCT microscopy images to a trained surgeon, carrying out a series of surgical procedures ex-vivo on a porcine eye model.}, keywords = {virtual reality, surgery guidance , real-time OCT, user experience}, year = {2019}, doi = {10.1117/12.2527123}, URL = {https://doi.org/10.1117/12.2527123} } |
Madita
Göb,
Tom
Pfeiffer, and
Robert
Huber,
Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , aciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. 072019. pp. 110780Y.
Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , aciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh, Eds. 072019. pp. 110780Y.
DOI: | 10.1117/12.2526796 |
Bibtex: | ![]() @inproceedings{10.1117/12.2526796, author = {Madita G{\"o}b and Tom Pfeiffer and Robert Huber}, title = {{Towards combined optical coherence tomography and multi-spectral imaging with MHz a-scan rates for endoscopy}}, volume = {11078}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {110780Y}, abstract = {We demonstrate a preliminary setup of a combined MHz-OCT and RGB narrowband reflection microscope and investigate the performance of the new RGB branch and different display modes of colored OCT data sets.}, keywords = {MHz OCT, multi-spectral imaging, Optical Coherence Tomography, Fourier Domain Mode Locked , FDML, RGB, Color }, year = {2019}, doi = {10.1117/12.2526796}, URL = {https://doi.org/10.1117/12.2526796} } |
Julian
Klee,
Jan Philip
Kolb,
Christin
Grill,
Wolfgang
Draxinger,
Tom
Pfeiffer, and
Robert
Huber,
Zero roll-off retinal MHz-OCT using an FDML-laser, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , SPIE, 072019. pp. 110780S.
Zero roll-off retinal MHz-OCT using an FDML-laser, in Optical Coherence Imaging Techniques and Imaging in Scattering Media III , SPIE, 072019. pp. 110780S.
DOI: | 10.1117/12.2527034 |
Datei: | 12.2527034.short |
Bibtex: | ![]() @inproceedings{10.1117/12.2527034, author = {Julian Klee and Jan Philip Kolb and Christin Grill and Wolfgang Draxinger and Tom Pfeiffer and Robert Huber}, title = {{Zero roll-off retinal MHz-OCT using an FDML-laser}}, volume = {11078}, booktitle = {Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, editor = {Maciej Wojtkowski and Stephen A. Boppart and Wang-Yuhl Oh}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {110780S}, abstract = {Optical coherence tomography (OCT) applications like ultra-widefield and full eye-length imaging are of high interest for various diagnostic purposes. In swept-source OCT these techniques require a swept light source, which is coherent over the whole imaging depth. We present a zero roll-off 1060 nm Fourier Domain Mode Locked-Laser (FDML-Laser) for retinal OCT imaging at 1.7 MHz A-scan rate and first long-range imaging results with it. Several steps such as improved dispersion compensation and frequency regulation were performed and will be discussed. Besides virtually no loss in OCT signal over the maximum depth range of 4.6 mm and very good dynamic range was observed. Roll-off measurements show no decrease of the point-spread function (PSF), while maintaining a high dynamic range.}, keywords = {optical coherence tomography, OCT, tunable laser, Fourier Domain Mode Locking, FDML, MHz OCT}, year = {2019}, doi = {10.1117/12.2527034}, URL = {https://doi.org/10.1117/12.2527034} } |
Daniel
Weng,
Hubertus
Hakert,
Torben
Blömker,
Jan Philip
Kolb,
Matthias
Strauch,
Matthias
Eibl,
Philipp
Lamminger,
Sebastian
Karpf, and
Robert
Huber,
Sub-Nanosecond Pulsed Fiber Laser for 532nm Two-Photon Excitation Fluorescence (TPEF) Microscopy of UV Transitions, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , IEEE, 062019. pp. 1-1.
Sub-Nanosecond Pulsed Fiber Laser for 532nm Two-Photon Excitation Fluorescence (TPEF) Microscopy of UV Transitions, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , IEEE, 062019. pp. 1-1.
DOI: | 10.1109/CLEOE-EQEC.2019.8872571 |
Bibtex: | ![]() @INPROCEEDINGS{8872571, author={Weng, Daniel and Hakert, Hubertus and Blömker, Torben and Kolb, Jan Philip and Strauch, Matthias and Eibl, Matthias and Lamminger, Philipp and Karpf, Sebastian and Huber, Robert}, booktitle={2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC)}, title={Sub-Nanosecond Pulsed Fiber Laser for 532nm Two-Photon Excitation Fluorescence (TPEF) Microscopy of UV Transitions}, year={2019}, volume={}, number={}, pages={1-1}, abstract={Summary form only given. Two-photon microscopy is a powerful technique for in vivo imaging, due to its high penetration depth and axial sectioning. Usually excitation wavelengths in the near infrared are used. However, most fluorescence techniques for live cell imaging require labeling with exogenous fluorophores. It has been shown that shorter wavelengths can be used to excite the autofluorescence of endogenous proteins, e.g. tryptophan. Recently we demonstrated a fully fiber-based laser source built around a directly modulated, ytterbium amplified 1064 nm laser diode with sub-nanosecond pulses for two-photon imaging [2]. The overall system enables to capture high-speed fluorescence lifetime imaging (FLIM) with single pulse excitation. Here, we extend the spectral range of this laser source by frequency doubling it to 532nm to achieve two-photon excited fluorescence microscopy (TPM) in the ultraviolett (UV) range to harness endogenous autofluorescence. In this presentation we explore first TPM results of tryptophan to investigate signal levels and fi delity before transitioning to biological tissues. It has been shown that TPM of endogenous tryptophan can be used to visualize immune system activity in vivo. Our laser source could be a cheap, flexible and fiber-based alternative to the OPO-based Ti:Sa Lasers currently employed. The basic concept of our design is to shift the wavelength of the pulsed fiber-based master oscillator power amplifier (MOPA) by second-harmonic generation (SHG) using phase-matching in a KTP crystal. This generates a coherent output at 532nm at a maximal peak power of 500W. We achieved a maximum conversion efficiency of about 17%. After the SHG module, the 532nm light is coupled into a single-mode fiber and delivered to a home built microscope. A 40x microscope objective is used to excite the sample and epi-collect the fluorescence. The fluorescence is recorded on a UV-enhanced photomultiplier tube (PMT). For a proof of concept measurement, crystalized tryptophan was imaged. Here we show signals of pure tryptophan, with laser parameters of 1MHz repetition rate and 100ps pulse duration. We used spectral bandpass fi lters in order to detect only fluorescence signal, however, from crystalized tryptophan we observed an unexpected short lifetime. We have recently shown that we can shift our laser output from 1064nm to longer wavelengths. By shifting to 1180nm and frequency doubling to 590nm a more efficient fluorescence excitation of tryptophan can be achieved. In the future we aim at in vivo imaging with our setup.}, keywords={}, doi={10.1109/CLEOE-EQEC.2019.8872571}, ISSN={}, month={June}} |
Jan Philip
Kolb,
Wolfgang
Draxinger,
Julian
Klee,
Tom
Pfeiffer,
Matthias
Eibl,
Thomas
Klein,
Wolfgang
Wieser, and
Robert
Huber,
Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates, PLOS ONE , vol. 14, no. 7, pp. e0213144, 03 2019.
Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates, PLOS ONE , vol. 14, no. 7, pp. e0213144, 03 2019.
DOI: | 10.1371/journal.pone.0213144 |
Bibtex: | ![]() @article{Kolb2019, author = {Kolb, J P;Draxinger, W;Klee, J;Pfeiffer, T;Eibl, M;Klein, T;Wieser, W and Huber, R}, title = {Live video rate volumetric OCT imaging of the retina with multi-MHz A-scan rates}, journal = {J pone}, keywords = {AG-Huber_OCT}, url = {https://doi.org/10.1371/journal.pone.0213144}, pages = {e0213144}, ISSN = {1932-6203}, year = {2019}, type = {Journal Article} } |
Hendrik
Spahr,
Clara
Pfäffle,
Gereon
Hüttmann, and
Dierck
Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt. Lett. , vol. 44, no. 6, pp. 1315--1318, 03 2019. Optica Publishing Group.
DOI: | 10.1364/OL.44.001315 |
Datei: | abstract.cfm |
Bibtex: | ![]() @article{RN5085, author = {Spahr, H;Pfäffle, C;Hüttmann, G and Hillmann, D}, title = {Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion}, journal = {Optics letters}, volume = {44(5)}, pages = {1315-1318}, DOI = {https://doi.org/10.1364/OL.44001315}, url = {https://doi.org/10.1364/OL.44001315}, year = {2019}, type = {Journal Article} } |
Jan Philip
Kolb,
Daniel
Weng,
Hubertus
Hakert,
Matthias
Eibl,
Wolfgang
Draxinger,
Tobias
Meyer-Zedler,
Thomas
Gottschall,
Ralf
Brinkmann,
Reginald
Birngruber,
Jürgen
Popp,
Jens
Limpert,
Sebastian
Karpf, and
Robert
Huber,
Virtual HE histology by fiber-based picosecond two-photon microscopy, in Multiphoton Microscopy in the Biomedical Sciences XIX , Ammasi Periasamy; Peter T. C. So; Karsten König, Eds. International Society for Optics and Photonics, 022019. pp. 108822F.
Virtual HE histology by fiber-based picosecond two-photon microscopy, in Multiphoton Microscopy in the Biomedical Sciences XIX , Ammasi Periasamy; Peter T. C. So; Karsten König, Eds. International Society for Optics and Photonics, 022019. pp. 108822F.
DOI: | 10.1117/12.2507866 |
Bibtex: | ![]() @inproceedings{10.1117/12.2507866, author = {Jan Philip Kolb and Daniel Weng and Hubertus Hakert and Matthias Eibl and Wolfgang Draxinger and Tobias Meyer and Thomas Gottschall and Ralf Brinkmann and Reginald Birngruber and J{\"u}rgen Popp and Jens Limpert and Sebastian Nino Karpf and Robert Huber}, title = {{Virtual HE histology by fiber-based picosecond two-photon microscopy}}, volume = {10882}, booktitle = {Multiphoton Microscopy in the Biomedical Sciences XIX}, editor = {Ammasi Periasamy and Peter T. C. So and Karsten K{\"o}nig}, organization = {International Society for Optics and Photonics}, publisher = {SPIE}, pages = {108822F}, abstract = {Two-Photon Microscopy (TPM) can provide three-dimensional morphological and functional contrast in vivo. Through proper staining, TPM can be utilized to create virtual, HE equivalent images and thus can improve throughput in histology-based applications. We previously reported on a new light source for TPM that employs a compact and robust fiber-amplified, directly modulated laser. This laser is pulse-to-pulse wavelength switchable between 1064 nm, 1122 nm, and 1186 nm with an adjustable pulse duration from 50ps to 5ns and arbitrary repetition rates up to 1MHz at kW-peak powers. Despite the longer pulse duration, it can achieve similar average signal levels compared to fs-setups by lowering the repetition rate to achieve similar cw and peak power levels. The longer pulses lead to a larger number of photons per pulse, which yields single shot fluorescence lifetime measurements (FLIM) by applying a fast 4 GSamples/s digitizer. In the previous setup, the wavelengths were limited to 1064 nm and longer. Here, we use four wave mixing in a non-linear photonic crystal fiber to expand the wavelength range down to 940 nm. This wavelength is highly suitable for imaging green fluorescent proteins in neurosciences and stains such as acridine orange (AO), eosin yellow (EY) and sulforhodamine 101 (SR101) used for histology applications. In a more compact setup, we also show virtual HE histological imaging using a direct 1030 nm fiber MOPA.}, keywords = {Multiphoton Microscopy, Four Wave Mixing, FWM, Histology, Laser, Non Linear Microscopy, Two Photon Microscopy, JenLab Young Investigator Award}, year = {2019}, doi = {10.1117/12.2507866}, URL = {https://doi.org/10.1117/12.2507866} } |
P-C
South, and
S A
Boppart,
Local wavefront mapping in tissue using computational adaptive optics OCT, Opt Lett 44(5) , no. 5, pp. 1186--1189, 2019. OSA.
Local wavefront mapping in tissue using computational adaptive optics OCT, Opt Lett 44(5) , no. 5, pp. 1186--1189, 2019. OSA.
DOI: | 10.1364/OL.44.001186 |
Bibtex: | ![]() @article{South:19, author = { South,F A; Liu, Y-Z; Huang, P-C and Kohlfärber, T and Boppart, S A}, journal = { Opt Lett 44(5)}, pages = {1186--1189}, keywords = {Adaptive optics; Image metrics; Image quality; Refractive index; Speckle noise; Wavefront aberrations}, number = {5}, publisher = {OSA}, title = {Local wavefront mapping in tissue using computational adaptive optics OCT}, year = {2019}, doi = {10.1364/OL.44.001186}, abstract = {The identification and correction of wavefront aberrations is often necessary to achieve high-resolution optical images of biological tissues, as imperfections in the optical system and the tissue itself distort the imaging beam. Measuring the localized wavefront aberration provides information on where the beam is distorted and how severely. We have recently developed a method to estimate the single-pass wavefront aberrations from complex optical coherence tomography (OCT) data. Using this method, localized wavefront measurement and correction using computational OCT was performed in ex vivo tissues. The computationally measured wavefront varied throughout the imaged OCT volumes and, therefore, a local wavefront correction outperformed a global wavefront correction. The local wavefront measurement was also used to generate tissue aberration maps. Such aberration maps could potentially be used as a new form of tissue contrast.}, } |
Kenneth S.
Barcikowski, and
Alfred
Vogel,
Materials synthesis in a bubble, MRS Bulletin , vol. 44 (5), pp. 382--391, 2019.
Materials synthesis in a bubble, MRS Bulletin , vol. 44 (5), pp. 382--391, 2019.
DOI: | 10.1557/mrs.2019.107 |
Bibtex: | ![]() @article{Vogel2019-2, title = {Materials synthesis in a bubble}, author = {Barcikowski, Stephan;Plech, Anton;Suslick, Kenneth S. and Vogel, Alfred}, year = 2019, journal = {MRS Bulletin}, volume = {44 (5)}, pages = {382--391}, doi = {10.1557/mrs.2019.107}, issn = {0883-7694}, type = {Journal Article} } |
D Casper,
Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography, J Biomed Opt , pp. 046005 - 1 - 11, 2019.
Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography, J Biomed Opt , pp. 046005 - 1 - 11, 2019.
Datei: | 1.JBO.24.4.046005 |
Bibtex: | ![]() @article{ citation_key = { Casper19}, author = { Casper, M; Schulz-Hildebrandt, H; Evers, M; Birngruber,R; Manstein, D and Hüttmann, G}, title = {Optimization-based vessel segmentation pipeline for robust quantification of capillary networks in skin with optical coherence tomography angiography}, journal = {J Biomed Opt}, pages = {046005 - 1 - 11}, year = {2019}, URL = {https://doi.org/10.1117/1.JBO.24.4.046005}, eprint = {} } |
Dominic
Kastner,
Torben
Blömker,
Tom
Pfeiffer,
Christin
Grill,
Mark
Schmidt,
Christian
Jirauschek, and
Robert
Huber,
Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference , Optical Society of America, 2019. pp. 1-1.
Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser, in 2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference , Optical Society of America, 2019. pp. 1-1.
DOI: | 10.1109/CLEOE-EQEC.2019.8872860 |
Bibtex: | ![]() @inproceedings{Kastner:19, author = {Kastner, D; Bl\"{o}mker, T; Pfeiffer, T; Grill, C; Schmidt, M; Jirauschek, C and Huber, R}, booktitle = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference}, journal = {2019 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference}, keywords = {Fourier domain mode locking; Image quality; Optical coherence tomography; Phase noise; Ring lasers; Tunable lasers}, pages = {cj_7_5}, publisher = {Optical Society of America}, title = {Measurement of Inter-Sweep Phase Stability of an FDML Laser with a 10 kHz Tunable Ring Laser}, year = {2019}, keywords = {AG-Huber_FDML, AG-Huber_OCT}, doi = { 10.1109/CLEOE-EQEC.2019.8872860}, abstract = {Fourier Domain Mode Locking (FDML) lasers are light sources that generate a sequence of narrowband optical frequency sweeps at the fundamental or harmonic of the cavity repetition rate \[1\]. This frequency swept output can also be considered as a sequence of strongly chirped, long pulses. FDML lasers are mainly used in swept source optical coherence tomography (SS-OCT), a medical imaging technique. The coherence length of the source, i.e. the intra-sweep phase stability of an FDML sweep, is decisive for the image quality and performance of OCT imaging \[2\].}, } |
Robert
Schmidt, and
Christian
Jirauschek,
Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers, pp. 1-1, 2019.
Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers, pp. 1-1, 2019.
DOI: | 10.1109/CLEOE-EQEC.2019.8873213 |
Bibtex: | ![]() @article{Schmidt2019, author = {Schmidt, Mark;Pfeiffer, Tom;Grill, Christin;Huber, Robert and Jirauschek, Christian}, title = {Modeling of the Ultra-Stable Operating Regime in Fourier Domain Mode Locked (FDML) Lasers}, pages = {1-1}, DOI = {10.1109/CLEOE-EQEC.2019.8873213}, year = {2019}, type = {Book}, booktitle = { 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference} } |
Z
Liang, and
A
Vogel,
Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water, Opt Expr , pp. 4672-4693, 2019.
Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water, Opt Expr , pp. 4672-4693, 2019.
DOI: | 10.1364/OE.27.004672 |
Bibtex: | ![]() @article{Liang2019, author = {Liang, X-X; Zhang, Z and Vogel, A}, title = {Multi-rate-equation modeling of the energy spectrum of laser-induced conduction band electrons in water}, journal = {Opt Expr}, pages = {4672-4693}, DOI = {10.1364/OE.27.004672}, year = {2019}, type = {Journal Article} } |
B
Burri, and
C
Meier,
Optical coherence tomography controlled selective retina therapy with a novel microsecond laser., .... SPIE, 2019.
Optical coherence tomography controlled selective retina therapy with a novel microsecond laser., .... SPIE, 2019.
Datei: | 12.2526720 |
Bibtex: | ![]() @book{Burri2019, author = {Burri, C;Hutfilz, A;Grimm, L;Arnold, P;Ebneter, A;Brinkmann, R;Theisen-Kunde, D;Považay, B and Meier, C}, title = {Optical coherence tomography controlled selective retina therapy with a novel microsecond laser}, publisher = {SPIE}, volume = {11079}, keywords = {Selective retina therapy, Retinal pigment epithelium, (170.0170) Medical optics and biotechnology, (170.4500) Optical coherence tomography, (170.4460) Ophthalmic optics and devices, instrumentation, (170.4470) Ophthalmology}, series = {European Conferences on Biomedical Optics}, url = {https://doi.org/10.1117/12.2526720}, year = {2019}, type = {Book} } |
Frank
Strittmatter,
Maximilian
Eisel,
Ralf
Brinkmann,
Birgit
Lange,
Jens
Cordes, and
Ronald
Sroka,
Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned, Translational Biophotonics , vol. n/a, no. n/a, pp. e201900029, 2019.
Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned, Translational Biophotonics , vol. n/a, no. n/a, pp. e201900029, 2019.
DOI: | 10.1002/tbio.201900029 |
Datei: | tbio.201900029 |
Bibtex: | ![]() @article{Brinkmann2020, author = {Strittmatter, F;Eisel, M; Brinkmann, R; Cordes, J;Lange, B and Sroka, R}, title = {Laser-induced lithotripsy: a review, insight into laboratory work, and lessons learned}, journal = {Translational Biophotonics}, volume = {n/a}, number = {n/a}, pages = {e201900029}, ISSN = {2627-1850}, DOI = {10.1002/tbio.201900029}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/tbio.201900029}, year = {2019}, type = {Journal Article} } |
Alexa
Klettner, and
Yoko
Miura,
Porcine RPE/choroidal explant cultures., .... 2019.
Porcine RPE/choroidal explant cultures., .... 2019.
ISBN: | 978-1-4939-8669-2 |
Datei: | 978-1-4939-8669-9_8 |
Bibtex: | ![]() @book{Miura2019, author = {Klettner, A and Miura, Y}, title = {Porcine RPE/choroidal explant cultures}, pages = {109-118 }, journal = {Weber B., Langmann T., Retinal Degeneration. Methods in Molecular Biology: 1834}, ISBN = {978-1-4939-8669-2}, URL = {https://doi.org/10.1007/978-1-4939-8669-9_8}, year = {2019}, type = {Book} } |
Gereon
Spahr, and
Dierck
Hillmann,
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific Reports , vol. 9(1), pp. 11748, 2019.
Phase-sensitive interferometry of decorrelated speckle patterns, Scientific Reports , vol. 9(1), pp. 11748, 2019.
Datei: | s41598-019-47979-8 |
Bibtex: | ![]() @article{Spahr-2019, title = {Phase-sensitive interferometry of decorrelated speckle patterns}, author = {Spahr, Hendrik;Pfäffle, Clara;Burhan, Sazan;Kutzner, Lisa;Hilge, Felix;Hüttmann, Gereon and Hillmann, Dierck}, year = 2019, journal = {Scientific Reports}, volume = {9(1)}, pages = 11748, issn = {2045-2322}, url = {https://doi.org/10.1038/s41598-019-47979-8}, type = {Journal Article} } |
Ramtin
Rahmanzadeh,
Florian
Rudnitzki, and
Gereon
Hüttmann,
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes, Journal of Biophotonics , pp. e201800460, 2019.
DOI: | 10.1002/jbio.201800460 |
Datei: | jbio.201800460 |
Bibtex: | ![]() @article{Rahmanzadeh-2019, author = {Rahmanzadeh, R;Rudnitzki, F and Hüttmann, G}, title = {Two ways to inactivate the Ki-67 protein—Fragmentation by nanoparticles, crosslinking with fluorescent dyes}, journal = {Journal of Biophotonics}, Year = {2019}, pages = {e201800460}, ISSN = {1864-063X}, DOI = {10.1002/jbio.201800460}, url = {https://onlinelibrary.wiley.com/doi/abs/10.1002/jbio.201800460}, type = {Journal Article} } |
Yoko
Miura,
Eric
Seifert,
Josua
Rehra,
Katharina
Kern,
Dirk
Theisen-Kunde,
Michael
Denton, and
Ralf
Brinkmann,
Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study, Int J Hyperth , pp. 1-7, 2019.
Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study, Int J Hyperth , pp. 1-7, 2019.
Datei: | 02656736.2019.1590653 |
Bibtex: | ![]() @article{Miura2019/4, author = {Miura, Y;Seifert, E;Rehra, J;Kern, K;Theisen-Kunde, D;Denton, M and Brinkmann, R}, title = {Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study}, journal = {Int J Hyperth}, pages = {1-7}, ISSN = {0265-6736}, url = {https://doi.org/10.1080/02656736.2019.1590653}, year = {2019}, type = {Journal Article} } |
Matthias
Strauch,
Jan Philip
Kolb,
Daniel
Weng,
Melanie
Wacker,
Wolfgang
Draxinger,
Sebastian
Karpf, and
Robert
Huber,
Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy, in 31st Congress of the ESP , 2019.
Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy, in 31st Congress of the ESP , 2019.
DOI: | 10.1007/s00428-019-02631-8 |
Bibtex: | ![]() @InProceedings{Strauch2019, author = {Strauch, Matthias and Kolb, Jan Philip and Weng, Daniel and Wacker, Melanie and Draxinger, Wolfgang and Karpf, Sebastian and Huber, Robert}, booktitle = {31st Congress of the ESP}, title = {Sectioning-Free Virtual H&E Imaging of Tissue Samples with Two-Photon Microscopy}, year = {2019}, keywords = {AG-Huber_NL}, } |
Timo
Kepp,
Christine
Droigk,
Malte
Casper,
Michael
Evers,
Gereon
Hüttmann,
Nunciada
Salma,
Dieter
Manstein,
Matthias P.
Heinrich, and
Heinz
Handels,
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks, Biomed Opt Expr 10(7) , pp. 3484-3496, 2019.
DOI: | 10.1364/BOE.10.003484 |
Datei: | BOE.10.003484 |
Bibtex: | ![]() @article{Hüttmann2019, author = {Kepp, T;Droigk, C;Casper, M;Evers, M;Hüttmann, G;Salma, N;Manstein, D;Heinrich, M P. and Handels, H}, title = {Segmentation of mouse skin layers in optical coherence tomography image data using deep convolutional neural networks}, journal = {Biomed Opt Expr 10(7)}, pages = {3484-3496}, DOI = {10.1364/BOE.10.003484}, url = {https://doi.org/10.1364/BOE.10.003484}, year = {2019}, type = {Journal Article} } |
Boris
Považay,
Ralf
Brinkmann,
Markus
Stoller, and
Ralf
Kessler,
Selective Retina Therapy, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 237-259.
Selective Retina Therapy, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 237-259.
DOI: | https://doi.org/10.1007/978-3-030-16638-0_11 |
ISBN: | 978-3-030-16638-0 |
Datei: | 978-3-030-16638-0_11 |
Bibtex: | ![]() @inbook{Brinkmann2019, author = {Považay, Boris;Brinkmann, Ralf;Stoller, Markus and Kessler, Ralf}, title = {Selective Retina Therapy}, booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics}, editor = {Bille, Josef F.}, publisher = {Springer International Publishing}, address = {Cham}, pages = {237-259}, ISBN = {978-3-030-16638-0}, url = {https://doi.org/10.1007/978-3-030-16638-0_11}, year = {2019}, type = {Book Section} } |
Clara
Pfäffle,
Hendrik
Spahr,
Lisa
Kutzner,
Sazan
Burhan,
Felix
Hilge,
Yoko
Miura,
Gereon
Hüttmann, and
Dierck
Hillmann,
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina, Optics Letters 44(23) , pp. 5671-5674, 2019.
DOI: | 10.1364/OL.44.005671 |
Bibtex: | ![]() @article{Pfäffle2019, author = {Pfäffle, C;Spahr, H;Kutzner, L;Burhan, S;Hilge, F;Miura, Y;Hüttmann, G and Hillmann, D}, title = {Simultaneous functional imaging of neuronal and photoreceptor layers in living human retina}, journal = {Optics Letters 44(23)}, pages = {5671-5674}, DOI = {10.1364/OL.44.005671}, year = {2019}, type = {Journal Article} } |
Robert
Wang, and
Gijs
van Soest,
Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography, IEEE Transactions on Medical Imaging , vol. 39, no. 5, pp. 1535-1544, 2019.
Simultaneous morphological and flow imaging enabled by megahertz intravascular Doppler optical coherence tomography, IEEE Transactions on Medical Imaging , vol. 39, no. 5, pp. 1535-1544, 2019.
R
Tode, and
J
Roider,
Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung, Spitzenforschung in der Ophthalmologie , vol. 117.DOG Kongress, pp. 172-175, 2019.
Thermische Stimulation der Retina: von der translationalen Forschung zur experimentellen technischen Umsetzung, Spitzenforschung in der Ophthalmologie , vol. 117.DOG Kongress, pp. 172-175, 2019.
B Jalali,
Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera, Nature Photonics , 2019.
Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera, Nature Photonics , 2019.
Datei: | 337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera |
Bibtex: | ![]() @article{Karpf2019, author = {Jiang, Y;Karpf, S and Jalali, B}, title = {Time-stretch LiDAR as a spectrally scanned time-of-flight ranging camera}, journal = {Nature Photonics}, keywords={}, ISSN = {1749-4893}, URL = {https://www.researchgate.net/publication/337692338_Time-stretch_LiDAR_as_a_spectrally_scanned_time-of-flight_ranging_camera}, year = {2019}, type = {Journal Article} } |
C. Abbas,
Toward feedback temperature control for retinal laser treatment., .... SPIE, 2019.
Toward feedback temperature control for retinal laser treatment., .... SPIE, 2019.
Datei: | 12.2527169 |
Bibtex: | ![]() @book{Abbas-2019, author = {Abbas, H. S.;Kren, C.;Danicke, V.;Herzog, C. and Brinkmann, R.}, title = {Toward feedback temperature control for retinal laser treatment}, publisher = {SPIE}, volume = {11079}, keywords = {Retina, Laser, Temperature, Optoacoustics, Photocoagulation, System identification, Automatic control}, series = {European Conferences on Biomedical Optics}, url = {https://doi.org/10.1117/12.2527169}, year = {2019}, type = {Book} } |
E Bliedtner,
Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty, TVST 8(6) , 2019.
Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty, TVST 8(6) , 2019.
DOI: | 10.1167/tvst.8.6.24 |
Bibtex: | ![]() @article{Bliedtner2019, author = {Bliedtner, K;Seifert, E and Brinkmann, R}, title = {Towards Automatically Controlled Dosing for Selective Laser Trabeculoplasty}, journal = {TVST 8(6)}, ISSN = {2164-2591}, DOI = {10.1167/tvst.8.6.24}, year = {2019}, type = {Journal Article} } |
Hinnerk
Schulz-Hildebrandt,
Naja
Meyer-Schell,
Malte
Casper,
Michael
Evers, and
Dieter
Manstein,
Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe, in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--3.
Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe, in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--3.
DOI: | 10.1117/12.2527087 |
ISBN: | 9781510628397 |
Bibtex: | ![]() @inproceedings{Schulz-Hildebrandt2019, author = {Schulz-Hildebrandt, Hinnerk and Meyer-Schell, Naja and Casper, Malte and Evers, Michael and Birngruber, Reginald and Manstein, Dieter and H{\"{u}}ttmann, Gereon}, booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II}, doi = {10.1117/12.2527087}, isbn = {9781510628397}, number = {110730L}, pages = {1--3}, title = {{Monitoring temperature induced phase changes in subcutaneous fatty tissue using an astigmatism corrected dynamic needle probe}}, keywords = {OCT, Endoskope}, year = { 2019} } |
Tabea
Kohlfaerber,
Ding
Shujun,
Ramtin
Rahmanzadeh,
Thomas
Jüngst,
Jürgen
Groll,
Hinnerk
Schulz-Hildebrandt, and
Gereon
Hüttmann,
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT, Transactions on Additive Manufacturing Meets Medicine 1(1) , 2019.
DOI: | 10.18416/AMMM.2019.1909S03P19 |
Bibtex: | ![]() @article{Kohlfärber2019, author = {Kohlfaerber, T;Ding, S;Rahmanzadeh, R;Jüngst, T;Groll, J;Schulz-Hildebrandt, H and Hüttmann, G}, title = {Investigation of cell dynamics in 3D cell spheroids and cell interaction with 3D printed scaffolds by mOCT}, journal = {Transactions on Additive Manufacturing Meets Medicine 1(1)}, DOI = {10.18416/AMMM.2019.1909S03P19}, year = {2019}, type = {Journal Article} } |
R
Freidank, and
N.
Linz,
Correction of hyperopia by intrastromal cutting and liquid filler injection, J Biomed Opt , no. 5%J Journal of Biomedical Optics, pp. 1-7, 7, 2019.
Correction of hyperopia by intrastromal cutting and liquid filler injection, J Biomed Opt , no. 5%J Journal of Biomedical Optics, pp. 1-7, 7, 2019.
Datei: | 1.JBO.24.5.058001 |
Bibtex: | ![]() @article{Freidank2019, author = {Freidank, S;Vogel, A;Anderson, R. R.;Birngruber, R and Linz, N}, title = {Correction of hyperopia by intrastromal cutting and liquid filler injection}, journal = {J Biomed Opt}, number = {5%J Journal of Biomedical Optics}, pages = {1-7, 7}, url = {https://doi.org/10.1117/1.JBO.24.5.058001}, year = {2019}, type = {Journal Article} } |
P
Münter, and
G
H\"{u}ttmann,
4D microscopic optical coherence tomography imaging of ex vivo mucus transport, in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III , 2019. pp. 1--5.
4D microscopic optical coherence tomography imaging of ex vivo mucus transport, in Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III , 2019. pp. 1--5.
ISBN: | 9781510628496 |
Datei: | 12.2527138.full |
Bibtex: | ![]() @inproceedings{Muenter2019, title = {4D microscopic optical coherence tomography imaging of ex vivo mucus transport}, author = { M\"{u}nter, M; Schulz-Hildebrandt, H; Pieper, M; K\"{o}nig, P and H\"{u}ttmann, G}, url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11078/2527138/4D-microscopic-optical-coherence-tomography-imaging-of-ex-vivo-mucus/10.1117/12.2527138.full}, isbn = {9781510628496}, year = {2019}, date = {2019-01-01}, booktitle = {Proc. SPIE 11078, Optical Coherence Imaging Techniques and Imaging in Scattering Media III}, volume = {11078}, number = {11}, pages = {1--5}, keywords = {OCM}, pubstate = {published}, tppubtype = {inproceedings} } |
Dierck
Hillmann,
Clara
Pfäffle,
Hendrik
Spahr,
Helge
Sudkamp,
Gesa
Franke, and
Gereon
Hüttmann,
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 181-194.
In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells, in High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics , Bille, Josef F., Eds. Cham: Springer International Publishing, 2019, pp. 181-194.
ISBN: | 978-3-030-16638-0 |
Datei: | 978-3-030-16638-0_8 |
Bibtex: | ![]() @inbook{Hillmann2019, author = {Hillmann, Dierck;Pfäffle, Clara;Spahr, Hendrik;Sudkamp, Helge;Franke, Gesa and Hüttmann, Gereon}, title = {In Vivo FF-SS-OCT Optical Imaging of Physiological Responses to Photostimulation of Human Photoreceptor Cells}, booktitle = {High Resolution Imaging in Microscopy and Ophthalmology: New Frontiers in Biomedical Optics}, editor = {Bille, Josef F.}, publisher = {Springer International Publishing}, address = {Cham}, pages = {181-194}, ISBN = {978-3-030-16638-0}, url = {https://doi.org/10.1007/978-3-030-16638-0_8}, year = {2019}, type = {Book Section} } |
H
Ahrens, and
G
H\"{u}ttmann,
An endomicroscopic OCT for clinical trials in the field of ENT (Invited), in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--4.
An endomicroscopic OCT for clinical trials in the field of ENT (Invited), in Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II , 2019. pp. 1--4.
ISBN: | 9781510628397 |
Datei: | 12.2527099.full |
Bibtex: | ![]() @inproceedings{Ahrens2019, title = {An endomicroscopic OCT for clinical trials in the field of ENT (Invited)}, author = { Ahrens, M; Idel, C; Chaker, A; Wollenberg, B; K\"{o}nig, P; Schulz-Hildebrandt, H and H\"{u}ttmann, G}, url = {https://www.spiedigitallibrary.org/conference-proceedings-of-spie/11073/2527099/An-endomicroscopic-OCT-for-clinical-trials-in-the-field-of/10.1117/12.2527099.full}, isbn = {9781510628397}, year = {2019}, date = {2019-01-01}, booktitle = {Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II}, number = {110730U}, pages = {1--4}, keywords = {Endoskope, meos, OCM}, pubstate = {published}, tppubtype = {inproceedings} } |
Martin
Rudolf,
Christine A
Curcio,
Ursula
Schlötzer-Schrehardt,
Armin Mir
Mohi Sefat,
Aysegül
Tura,
Max Philipp
Brinkmann,
Salvatore
Grisanti,
Yoko
Miura, and
Mahdy
Ranjbar,
Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates, Invest Ophthalmol Vis Sci , pp. 461-472, 2019.
Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates, Invest Ophthalmol Vis Sci , pp. 461-472, 2019.
DOI: | 10.1167/iovs.18-25786 |
Datei: | 30707219 |
Bibtex: | ![]() @article{Miura2019-2, author = {Rudolf, M; Curcio, C A; Schlözer-Schrehardt, U; Sefat, A M M; Tura, A; Aherrahrou, Z; Brinkmann, M; Grisanti, S; Miura, Y and Ranjbar, M}, title = {Apolipoprotein A-I mimetic peptide L-4F removes Bruch's membrane lipids in aged nonhuman primates}, journal = {Invest Ophthalmol Vis Sci}, pages = {461-472}, url = {https://www.ncbi.nlm.nih.gov/pubmed/30707219}, year = {2019}, type = {Journal Article} } |
D. Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Optics letters , vol. 44(5), pp. 1315-1318, 2019.
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Optics letters , vol. 44(5), pp. 1315-1318, 2019.
DOI: | https://doi.org/10.1364/OL.44001315 |
Datei: | OL.44001315 |
Bibtex: | ![]() @article{Spahr2019, author = {Spahr, H;Pfäffle, C;Huettmann, G and Hillmann, D}, title = {Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion}, journal = {Optics letters}, volume = {44(5)}, pages = {1315-1318}, DOI = {https://doi.org/10.1364/OL.44001315}, url = {https://doi.org/10.1364/OL.44001315}, year = {(2019)}, type = {Journal Article} } |
C.
Pfäffle, and
D.
Hillmann,
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt Lett , pp. 1315-1318, 2019.
Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion, Opt Lett , pp. 1315-1318, 2019.
Datei: | OL.44.001315 |
Bibtex: | ![]() @article{Spahr2019, author = {Spahr, H; Pfäffle, C; Huettmann, G and Hillmann, D}, title = { Artifacts in speckle tracking and multi-aperture Doppler OCT imaging of lateral motion}, journal = { Opt Lett}, pages = {1315-1318}, URL = {https://doi.org/10.1364/OL.44.001315}, year = {2019}, type = {Journal Article} } |
M. J.
Casper,
J.
Glahn,
M.
Evers,
G.
Kositratna,
G.
H\"{u}ttmann, and
D.
Manstein,
Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography, Lasers in Surgery and Medicine , 2019.
Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography, Lasers in Surgery and Medicine , 2019.
DOI: | 10.1002/lsm.23188 |
Bibtex: | ![]() @article{Casper2019b, title = {Capillary Refill - The Key to Assessing Dermal Capillary Capacity and Pathology in Optical Coherence Tomography Angiography}, author = {Casper, M. J. and Glahn, J. and Evers, M. and Schulz-Hildebrandt, H. and Kositratna, G. and Birngruber, R. and H\"{u}ttmann, G. and Manstein, D.}, doi = {10.1002/lsm.23188}, year = {2019}, date = {2019-11-22}, journal = {Lasers in Surgery and Medicine}, abstract = {Background/Objectives Standard optical coherence tomography angiography (OCTA) has been limited to imaging blood vessels actively undergoing perfusion, providing a temporary picture of surface microvasculature. Capillary perfusion in the skin is dynamic and changes in response to the surrounding tissue's respiratory, nutritional, and thermoregulatory needs. Hence, OCTA often represents a given perfusion state without depicting the actual extent of the vascular network. Here we present a method for obtaining a more accurate anatomic representation of the surface capillary network in human skin using OCTA, along with proposing a new parameter, the Relative Capillary Capacity (RCC), a quantifiable proxy for assessing capillary dilation potential and permeability. Methods OCTA images were captured at baseline and after compression of the skin. Baseline images display ambient capillary perfusion, while images taken upon capillary refill display the network of existing capillaries at full capacity. An optimization-based automated vessel segmentation method was used to automatically analyze and compare OCTA image sequences obtained from two volunteers. RCC was then compared with visual impressions of capillary viability. Results Our OCTA imaging sequence provides a method for mapping cutaneous capillary networks independent of ambient perfusion. Differences between baseline and refill images clearly demonstrate the shortcomings of standard OCTA imaging and produce the RCC biometric as a quantifiable proxy for assessing capillary dilation potential and permeability. Conclusion Future dermatological OCTA diagnostic studies should implement the Capillary Refill Methods over standard imaging techniques and further explore the relevance of RCC to differential diagnosis and dermatopathology. \textbf{Lasers Surg. Med. © The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals, Inc.}}, keywords = {mOCT}, pubstate = {published}, tppubtype = {article} } |
Yoko
Miura,
Britta
Lewke,
Alessa
Hutfilz, and
Ralf
Brinkmann,
Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress, Nippon Ganka Gakkai Zasshi , pp. 105-114, 2019.
Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress, Nippon Ganka Gakkai Zasshi , pp. 105-114, 2019.
Datei: | Disp |
Bibtex: | ![]() @article{Miura2019/3, author = {Miura, Y;Lewke, B;Hutfilz, A and Brinkmann, R}, title = {Change in fluorescence lifetime of retinal pigment epithelium under oxidative stress}, journal = {Nippon Ganka Gakkai Zasshi }, pages = {105-114}, url = {http://journal.nichigan.or.jp/Disp?style=abst&vol=123&year=2019&mag=0&number=2&start=105}, year = {2019}, type = {Journal Article} } |
T
Espinoza, and
s
Zwart,
Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy, Particle and Particle Systems Characterization , 2019.
Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy, Particle and Particle Systems Characterization , 2019.
Datei: | 335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy |
Bibtex: | ![]() @article{Rahmanzadeh-2019-2, author = {Espinoza, S;Müller, M;Jenneboer, H;Peulen, L;Bradley, T;Purschke, M;Haase, M;Rahmanzadeh, R;Jüstel, T and Zwart, s}, title = {Characterization of Micro- and Nanoscale LuPO4:Pr3+,Nd3+ with Strong UV-C Emission to Reduce X-Ray Doses in Radiation Therapy}, journal = {Particle and Particle Systems Characterization}, URL = {https://www.researchgate.net/publication/335364547_Characterization_of_Micro-_and_Nanoscale_LuPO4Pr3Nd3_with_Strong_UV-C_Emission_to_Reduce_X-Ray_Doses_in_Radiation_Therapy}, year = {2019}, type = {Journal Article} } |
C
Wang, and
Z
Zhang,
Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma, ACS Applied Materials & Interfaces , 2019.
Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma, ACS Applied Materials & Interfaces , 2019.
DOI: | 10.1021/acsami.9b09560 |
Bibtex: | ![]() @article{Rahmanzadeh2019, author = {Wang, S;Liu, H;Xin, J;Rahmanzadeh, R;Wang, J;Yao, C and Zhang, Z}, title = {Chlorin-based photoactivable Galectin-3-inhibitor nanoliposome for enhanced photodynamic therapy and NK cell-related immunity in Melanoma}, journal = {ACS Applied Materials & Interfaces}, ISSN = {1944-8244}, DOI = {10.1021/acsami.9b09560}, year = {2019}, type = {Journal Article} } |
Mark
Schmidt,
Tom
Pfeiffer,
Christin
Grill,
Robert
Huber, and
Christian
Jirauschek,
Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 2019. pp. 1--1.
Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers, in 2019 Conference on Lasers and Electro-Optics Europe & European Quantum Electronics Conference (CLEO/Europe-EQEC) , 2019. pp. 1--1.
DOI: | 10.1109/CLEOE-EQEC.2019.8872381 |
Bibtex: | ![]() @inproceedings{schmidt2019coexistence, title={Coexistence of Intensity Pattern Types in Broadband Fourier Domain Mode Locked (FDML) Lasers}, author={Schmidt, M; Pfeiffer, T; Grill, C; Huber, R and Jirauschek, C}, booktitle={2019 Conference on Lasers and Electro-Optics Europe \& European Quantum Electronics Conference (CLEO/Europe-EQEC)}, pages={1--1}, year={2019}, organization={IEEE}, keywords= { AG-Huber_FDML}, url={ https://ieeexplore.ieee.org/document/8872381} } |
M.
Ourak,
J.
Smits,
L.
Esteveny,
G.
Borghesan,
A.
Gijbels,
L.
Schoevaerdts,
Y.G.M.
Douven,
J.
Scholtes,
E.
Lankenau,
G.
H{"u}ttmann,
M.
Kozlovszky,
Gernot
Kronreif,
K.
Willekens,
P.
Stalmans,
Koorosh
Faridpooya,
M.
Cereda,
A.
Giani,
G.
Staurenghi,
D.
Reynaerts, and
E. B.
Vander Poorten,
Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation, International Journal of Computer Assisted Radiology and Surgery , vol. 14, no. 2, pp. 301--309, 2019.
Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation, International Journal of Computer Assisted Radiology and Surgery , vol. 14, no. 2, pp. 301--309, 2019.
DOI: | 10.1007/s11548-018-1829-0 |
Datei: | s11548-018-1829-0 |
Bibtex: | ![]() @Article{Ourak2019, author="Ourak, M. and Smits, J. and Esteveny, L. and Borghesan, G. and Gijbels, A. and Schoevaerdts, L. and Douven, Y. and Scholtes, J. and Lankenau, E. and Eixmann, T. and Schulz-Hildebrandt, H. and H{\"u}ttmann, G. and Kozlovszky, M. and Kronreif, G. and Willekens, K. and Stalmans, P. and Faridpooya, K. and Cereda, M. and Giani, A. and Staurenghi, G. and Reynaerts, D. and Vander Poorten, E. B.", title="Combined OCT distance and FBG force sensing cannulation needle for retinal vein cannulation: in vivo animal validation", journal="International Journal of Computer Assisted Radiology and Surgery", year="2019", month="Feb", day="01", volume="14", number="2", pages="301--309", abstract="Retinal vein cannulation is an experimental procedure during which a clot-dissolving drug is injected into an obstructed retinal vein. However, due to the fragility and minute size of retinal veins, such procedure is considered too risky to perform manually. With the aid of surgical robots, key limiting factors such as: unwanted eye rotations, hand tremor and instrument immobilization can be tackled. However, local instrument anatomy distance and force estimation remain unresolved issues. A reliable, real-time local interaction estimation between instrument tip and the retina could be a solution. This paper reports on the development of a combined force and distance sensing cannulation needle, and its experimental validation during in vivo animal trials.", issn="1861-6429", doi="10.1007/s11548-018-1829-0", url="https://doi.org/10.1007/s11548-018-1829-0", citation_key = {Ourak2019} } |
Dierck
Hillmann,
Clara
Pfäffle,
Hendrik
Spahr,
Sazan
Burhan,
Lisa
Kutzner,
Felix
Hilge, and
Gereon
Hüttmann,
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations, Opt Lett 44 (15) , pp. 3905-3908, 2019.
DOI: | 10.1364/OL.44.003905 |
Datei: | 31368998 |
Bibtex: | ![]() @article{Hillmann2019, author = {Hillmann, D.;Pfaffle, C.;Spahr, H.;Burhan, S.;Kutzner, L.;Hilge, F. and Hüttmann, G.}, title = {Computational adaptive optics for optical coherence tomography using multiple randomized subaperture correlations}, journal = {Opt Lett 44 (15)}, pages = {3905-3908}, ISSN = {1539-4794 (Electronic) 0146-9592 (Linking)}, DOI = {10.1364/OL.44.003905}, url = {https://www.ncbi.nlm.nih.gov/pubmed/31368998}, year = {2019}, type = {Journal Article} } |
Kumiko
Hirayama,
Manabu
Yamamoto,
Takeya
Kohno,
Dirk
Theisen-Kunde,
Ralf
Brinkmann,
Yoko
Miura, and
Shigero
Honda,
Change in the Thickness of Retinal Layers after Selective Retina Therapy (SRT) in Patients with Central Serous Chorioretinopathy, Osaka City Med. , vol. 65, pp. 55-63, 2019.
Change in the Thickness of Retinal Layers after Selective Retina Therapy (SRT) in Patients with Central Serous Chorioretinopathy, Osaka City Med. , vol. 65, pp. 55-63, 2019.
Datei: | G0000438repository_00306096-65-1-55 |
Bibtex: | ![]() @article{Miura2019, author = {Hirayama, K;Manabu Yamamoto, M; Takeya Kohno, T; Miura, Y; Brinkmann, R; Shiraki,K;Theisen-Kunde, D; and Honda, S;}, title = {Change in the Thickness of Retinal Layers after Selective Retina Therapy (SRT) in Patients with Central Serous Chorioretinopathy}, journal = {Osaka City Med.}, volume = {65}, pages = {55-63}, url = {http://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_00306096-65-1-55}, year = {2019}, type = {Journal Article} } |
E Bliedtner,
Dosimetry for microsecond selective laser trabeculoplasty, in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX , 2019.
Dosimetry for microsecond selective laser trabeculoplasty, in Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX , 2019.
DOI: | 10.1117/12.2526987 |
Bibtex: | ![]() @inproceedings{Bliedtner2019, author = {Bliedtner,K; Seifert, E and Brinkmann,R}, title = {Dosimetry for microsecond selective laser trabeculoplasty}, volume = {11079}, DOI = {10.1117/12.2526987}, year = {2019}, keywords = {Ophthalmology, ophthalmic optics and devices, selective laser trabeculoplasty, micro bubble detection}, booktitle = {Proc. SPIE 11079, Medical Laser Applications and Laser-Tissue Interactions IX}, type = {Conference proceedings} } |
G
Burchard, and
J
Roider,
High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten, Spitzenforschung in der Ophthalmologie- , pp. 30-32, 2019.
High-Tech-Ophthalmologie zu Hause: Das Home-Care-OCT für AMD Patienten, Spitzenforschung in der Ophthalmologie- , pp. 30-32, 2019.